List of works - Haruhiko Fuwa

A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (−)-GAMBIEROL

A Concise Total Synthesis of (+)-Neopeltolide

scholarly article by Haruhiko Fuwa et al published 22 March 2010 in Angewandte Chemie International Edition

A Concise Total Synthesis of (±)-Centrolobine

article published in 2010

A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

scientific article published in 2011

A New Method for the Generation of Indole-2,3-quinodimethanes from Allenamides

A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

scientific article published on 20 October 2017

A Unified Total Synthesis of Aspergillides A and B

article by Haruhiko Fuwa et al published 16 April 2010 in Organic Letters

A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels–Alder cycloaddition cascade starting from acyclic α-phosphono enecarbamates

A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters

scholarly article by Haruhiko Fuwa et al published July 2011 in Tetrahedron

A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

An Efficient Strategy for the Synthesis of Endocyclic Enol Ethers and Its Application to the Synthesis of Spiroacetals

scientific article published in 2008

An Efficient Synthesis of 2,6-Disubstituted 2,3-Dihydro-4H-pyran-4-ones via Sonogashira Coupling of p-Toluenethiol Esters

An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine

article published in 2007

An enantioselective total synthesis of aspergillides A and B

article by Haruhiko Fuwa et al published September 2010 in Tetrahedron

Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans

article published in 2011

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

scientific article published in Journal of Biological Chemistry

Calcium oscillations induced by gambierol in cerebellar granule cells.

scientific article

Comparative cytotoxicity of gambierol versus other marine neurotoxins.

scientific article published on 4 May 2011

Complete Stereochemical Assignment of Campechic Acids A and B

Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements

scientific article

Concise synthesis of the A/BCD-ring fragment of gambieric acid A.

scientific article published in January 2014

Concise synthesis of the C15-C38 fragment of okadaic acid: application of the Suzuki-Miyaura reaction to spiroacetal synthesis

scientific article published on 26 December 2014

Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A

Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product

scientific article

Convergent Assembly of the Spiroacetal Subunit of Didemnaketal B

article published in 2010

Convergent strategies for the total synthesis of polycyclic ether marine metabolites

scientific article

Convergent synthesis of the ABCDE ring fragment of ciguatoxins

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications

scientific article

Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues: Elucidation of Crucial Structural Elements for Potent Toxicity

article

Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells

scientific article published on 25 July 2006

Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid.

scientific article published on 12 May 2016

Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study

scientific article published on 29 August 2012

Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity.

scientific article published on 13 December 2014

Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products

article published in 2016

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

scientific article published on 01 July 2019

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

scientific article published on 26 October 2009

Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells.

scientific article

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

scientific article published on 8 May 2006

Palladium-Catalyzed Synthesis of N- and O-Heterocycles Starting from Enol Phosphates

scholarly article by Haruhiko Fuwa published 10 December 2010 in Synlett

Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

scientific article published on 01 December 2003

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

scientific article published on 26 August 2014

Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions

scientific article

Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12–C36 Fragment

Proteomic analysis reveals multiple patterns of response in cells exposed to a toxin mixture

scientific article published in June 2009

Ruthenium-Catalyzed Intramolecular Double Hydroalkoxylation of Internal Alkynes

scientific article published on 05 December 2018

Stereocontrolled Synthesis of the A/B-Ring Fragment of Gambieric Acid B: Reassignment of the Absolute Configuration of the Polycyclic Ether Region

scientific article published in 2008

Stereocontrolled Synthesis of the DEFG-ring Skeleton of Gambieric Acids

Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Brønsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Ester Surrogates

article published in 2011

Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

scientific article published in 2010

Stereoselective Synthesis of the C1–C16 Fragment of Goniodomin A

Stereoselective Tandem Synthesis of syn-1,3-Diol Derivatives by Integrating Olefin Cross-Metathesis, Hemiacetalization, and Intramolecular Oxa-Michael Addition

scientific article published on 02 May 2019

Stereoselective synthesis of medium-sized cyclic ethers: application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts

scientific article published on 11 February 2014

Strategies for the Synthesis of 2-Substituted Indoles and Indolines Starting from Acyclic α-Phosphoryloxy Enecarbamates

article published in 2007

Studies toward the Total Synthesis of Amphidinolide N: Stereocontrolled Synthesis of the C13–C29 Segment

article

Studies toward the Total Synthesis of Gambieric Acids: Stereocontrolled Synthesis of a DEFG-Ring Model Compound

article

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment

article published in 2011

Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling

scientific article published on January 2011

Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

Synthesis and biological evaluation of (+)-neopeltolide analogues: importance of the oxazole-containing side chain

scientific article published on 18 April 2014

Synthesis and biological evaluation of gambierol analogues

scientific article

Synthesis of 2-substituted indoles and indolines via Suzuki-Miyaura coupling/5-endo-trig cyclization strategies

scientific article

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

scientific article published in 2006

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

Synthetic Studies toward Gambierol. Convergent Synthesis of the Octacyclic Polyether Core

scientific article published on 01 November 2001

Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

article published in 2005

Synthetic studies on antascomicin A: construction of the C18–C34 fragment

Synthetic studies on gambieric acids, potent antifungal polycyclic ether natural products: reassignment of the absolute configuration of the nonacyclic polyether core by NMR analysis of model compounds.

scientific article published in June 2009

Synthetic studies on goniodomin A: convergent assembly of the C15–C36 segment via palladium-catalyzed organostannane–thioester coupling

Tandem Three-Component Synthesis of syn-1,2- and syn-1,3-Diol Derivatives

scientific article published on 04 February 2020

Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives

Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology

scientific article

The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells

scientific article published on 9 June 2010

Total Synthesis and Biological Assessment of (−)-Exiguolide and Analogues

article by Haruhiko Fuwa et al published 24 January 2011 in Chemistry—A European Journal

Total Synthesis and Complete Stereostructure of Gambieric Acid A

article by Haruhiko Fuwa et al published 16 July 2012 in Journal of the American Chemical Society

Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B.

scientific article

Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

scientific article published on 31 January 2018

Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

Total Synthesis of (+)-Neopeltolide

scholarly article by Haruhiko Fuwa et al published 9 June 2008 in Angewandte Chemie International Edition

Total Synthesis of (−)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers

article published in 2011

Total Synthesis of (−)-Enigmazole A

scholarly article by Keisuke Sakurai et al published 24 March 2018 in Angewandte Chemie International Edition

Total Synthesis of (−)-Exiguolide

scientific article published in 2010

Total Synthesis of Polycyclic Ether Natural Products Based on Suzuki-Miyaura Cross-Coupling

Total Synthesis of Structurally Complex Marine Oxacyclic Natural Products

Total Synthesis of Tetrahydropyran-Containing Natural Products Exploiting Intramolecular Oxa-Conjugate Cyclization

article by Haruhiko Fuwa published 2012 in Heterocycles

Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide-2a

scientific article published on 17 May 2019

Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues

scientific article published on 28 March 2013

Total synthesis and biological evaluation of (+)-neopeltolide and its analogues

scientific article published on November 2009

Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone

scientific article published on 28 March 2013

Total synthesis and complete structural assignment of gambieric acid A, a large polycyclic ether marine natural product

scientific article published on 04 August 2014

Total synthesis and structure revision of didemnaketal B.

scientific article published on 15 January 2014

Total synthesis of (-)-brevenal: a concise synthetic entry to the pentacyclic polyether core

scientific article published on 30 April 2008

Total synthesis of (-)-gambierol

scientific article published in December 2002

Total synthesis of 13-demethyllyngbyaloside B.

scientific article published on 8 March 2013

Total synthesis of the proposed structure of brevenal

scientific article published in August 2006

Total synthesis of the proposed structure of didemnaketal B.

scientific article published on 22 July 2013

Total synthesis, stereochemical reassignment, and biological evaluation of (-)-lyngbyaloside B.

scientific article

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

scientific article published on December 2006

Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8–C29 Fragment

scientific article published in 2016

Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15−C36 Segment

scientific article published in 2009

List of works by Haruhiko Fuwa

A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (−)-GAMBIEROL

A Concise Total Synthesis of (+)-Neopeltolide

A Concise Total Synthesis of (±)-Centrolobine

A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

A New Method for the Generation of Indole-2,3-quinodimethanes from Allenamides

A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

A Unified Total Synthesis of Aspergillides A and B

A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels–Alder cycloaddition cascade starting from acyclic α-phosphono enecarbamates

A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters

A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

An Efficient Strategy for the Synthesis of Endocyclic Enol Ethers and Its Application to the Synthesis of Spiroacetals

An Efficient Synthesis of 2,6-Disubstituted 2,3-Dihydro-4H-pyran-4-ones via Sonogashira Coupling of p-Toluenethiol Esters

An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine

An enantioselective total synthesis of aspergillides A and B

Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

Calcium oscillations induced by gambierol in cerebellar granule cells.

Comparative cytotoxicity of gambierol versus other marine neurotoxins.

Complete Stereochemical Assignment of Campechic Acids A and B

Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements

Concise synthesis of the A/BCD-ring fragment of gambieric acid A.

Concise synthesis of the C15-C38 fragment of okadaic acid: application of the Suzuki-Miyaura reaction to spiroacetal synthesis

Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A

Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product

Convergent Assembly of the Spiroacetal Subunit of Didemnaketal B

Convergent strategies for the total synthesis of polycyclic ether marine metabolites

Convergent synthesis of the ABCDE ring fragment of ciguatoxins

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications

Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues: Elucidation of Crucial Structural Elements for Potent Toxicity

Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells

Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid.

Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study

Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity.

Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells.

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

Palladium-Catalyzed Synthesis of N- and O-Heterocycles Starting from Enol Phosphates

Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions

Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12–C36 Fragment

Proteomic analysis reveals multiple patterns of response in cells exposed to a toxin mixture

Ruthenium-Catalyzed Intramolecular Double Hydroalkoxylation of Internal Alkynes

Stereocontrolled Synthesis of the A/B-Ring Fragment of Gambieric Acid B: Reassignment of the Absolute Configuration of the Polycyclic Ether Region

Stereocontrolled Synthesis of the DEFG-ring Skeleton of Gambieric Acids

Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Brønsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Ester Surrogates

Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

Stereoselective Synthesis of the C1–C16 Fragment of Goniodomin A

Stereoselective Tandem Synthesis of syn-1,3-Diol Derivatives by Integrating Olefin Cross-Metathesis, Hemiacetalization, and Intramolecular Oxa-Michael Addition

Stereoselective synthesis of medium-sized cyclic ethers: application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts

Strategies for the Synthesis of 2-Substituted Indoles and Indolines Starting from Acyclic α-Phosphoryloxy Enecarbamates

Studies toward the Total Synthesis of Amphidinolide N: Stereocontrolled Synthesis of the C13–C29 Segment

Studies toward the Total Synthesis of Gambieric Acids: Stereocontrolled Synthesis of a DEFG-Ring Model Compound

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment

Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling

Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

Synthesis and biological evaluation of (+)-neopeltolide analogues: importance of the oxazole-containing side chain

Synthesis and biological evaluation of gambierol analogues

Synthesis of 2-substituted indoles and indolines via Suzuki-Miyaura coupling/5-endo-trig cyclization strategies

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

Synthetic Studies toward Gambierol. Convergent Synthesis of the Octacyclic Polyether Core

Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

Synthetic studies on antascomicin A: construction of the C18–C34 fragment

Synthetic studies on gambieric acids, potent antifungal polycyclic ether natural products: reassignment of the absolute configuration of the nonacyclic polyether core by NMR analysis of model compounds.

Synthetic studies on goniodomin A: convergent assembly of the C15–C36 segment via palladium-catalyzed organostannane–thioester coupling

Tandem Three-Component Synthesis of syn-1,2- and syn-1,3-Diol Derivatives

Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives

Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology

The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells

Total Synthesis and Biological Assessment of (−)-Exiguolide and Analogues

Total Synthesis and Complete Stereostructure of Gambieric Acid A

Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B.