List of works - Adelaide Fernandes

Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis

scientific article published on 30 July 2019

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

scientific article published on 6 November 2014

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

scientific article published in May 2007

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

scientific journal article

Automated analysis of NeuronJ tracing data

scientific article

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

scientific article published on August 2009

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

scientific article published on 19 November 2007

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

scientific article

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

scientific article published in November 2005

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

scientific article published on 19 December 2014

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

scientific article published on February 2009

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

scientific article published on January 2009

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

scientific article published in July 2014

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

scientific article

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

scientific article

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

scientific article

Dissociated primary nerve cell cultures as models for assessment of neurotoxicity

scientific article

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

scientific article published on 13 June 2017

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

scientific article published on 30 March 2017

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

scientific article published on 17 June 2012

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

scientific article published on May 2011

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

scientific article published in February 2015

Evidence of tricellulin expression by immune cells, particularly microglia

article

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

scientific article

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

scientific article published on 01 September 2007

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

scientific article published on 7 November 2017

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

scientific article published on 10 February 2006

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

scientific article published on 24 February 2007

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

scientific article published in April 2015

Interventions for age-related diseases: Shifting the paradigm

scientific article

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

scientific article

Microglia and inflammation: conspiracy, controversy or control?

scientific article published on 10 July 2014

Microglia change from a reactive to an age-like phenotype with the time in culture

scientific article

Microglial Phagocytosis-Rational but Challenging Therapeutic Target in Multiple Sclerosis

scientific article published on 19 August 2020

Modelling physical resilience in ageing mice

article

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

scientific article

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

scientific article published on 13 February 2012

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

scientific article

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

scientific article

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

scientific article published on 03 December 2015

Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease

scientific article

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

scientific article published on 16 March 2011

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors

scientific journal article

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

scientific article

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

scientific journal article

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

scientific article published on 17 July 2015

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

article by Adelaide Fernandes et al published May 2018 in Biochimie

Selective vulnerability of rat brain regions to unconjugated bilirubin

scientific article published on 25 June 2011

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

scientific article published on 29 April 2015

Temporal oligodendrocyte lineage progression: in vitro models of proliferation, differentiation and myelination.

scientific article published on 21 April 2014

Topical gels of etofenamate: in vitro and in vivo evaluation

scientific article published on 5 May 2014

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

article

Tricellulin expression in brain endothelial and neural cells

scientific article published on 19 December 2012

Unconjugated bilirubin activates and damages microglia

scientific article

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

scientific article published on 01 August 2007

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination

scientific article

List of works by Adelaide Fernandes

Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Automated analysis of NeuronJ tracing data

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

Dissociated primary nerve cell cultures as models for assessment of neurotoxicity

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

Evidence of tricellulin expression by immune cells, particularly microglia

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Interventions for age-related diseases: Shifting the paradigm

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

Microglia and inflammation: conspiracy, controversy or control?

Microglia change from a reactive to an age-like phenotype with the time in culture

Microglial Phagocytosis-Rational but Challenging Therapeutic Target in Multiple Sclerosis

Modelling physical resilience in ageing mice

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Selective vulnerability of rat brain regions to unconjugated bilirubin

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Temporal oligodendrocyte lineage progression: in vitro models of proliferation, differentiation and myelination.

Topical gels of etofenamate: in vitro and in vivo evaluation

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Tricellulin expression in brain endothelial and neural cells

Unconjugated bilirubin activates and damages microglia

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination