List of works - Ana R. Vaz

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

scientific journal article

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

scientific article published on 10 October 2009

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

scientific article published on 11 July 2018

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

scientific article published in July 2014

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

scientific article

Development of a high throughput methodology to screen cathinones' toxicological impact

scientific article published on 23 February 2019

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

scientific article published on 31 October 2016

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

scientific article published on 13 June 2017

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

scientific article published on 23 March 2011

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

scientific article published on 17 June 2012

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

scientific article published on May 2011

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

scientific article published on 17 May 2017

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

scientific article published on 21 December 2016

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

scientific article

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

scientific article published on 01 September 2007

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

scientific article published on 22 May 2014

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

scientific article

Microglia change from a reactive to an age-like phenotype with the time in culture

scientific article

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

scientific article

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

scientific article published on 13 February 2012

Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

scientific article published on 01 April 2022

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

scientific article published on 09 April 2019

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

scientific article published on 16 March 2011

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

article by Adelaide Fernandes et al published May 2018 in Biochimie

Selective vulnerability of rat brain regions to unconjugated bilirubin

scientific article published on 25 June 2011

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

scientific article published on 22 March 2019

Tricellulin expression in brain endothelial and neural cells

scientific article published on 19 December 2012

List of works by Ana R. Vaz

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

Development of a high throughput methodology to screen cathinones' toxicological impact

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

Microglia change from a reactive to an age-like phenotype with the time in culture

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Selective vulnerability of rat brain regions to unconjugated bilirubin

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

Tricellulin expression in brain endothelial and neural cells