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List of works by Jacintha O'Sullivan

A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia.

scientific article published on 15 January 2014

A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab

scientific article published on 29 December 2016

A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers

scientific article

Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis

scientific article published in August 2003

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma

scientific article

Angiogenesis and blood vessel stability in inflammatory arthritis

scientific article published in March 2010

Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors.

scientific article

Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer

scientific article published on 03 August 2012

Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.

scientific article published on 21 January 2010

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A

scientific article published on 16 April 2020

COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention

scientific article published on October 2011

Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

scientific article published on December 2009

Changes in hormone sensitivity in the ventral prostate of aging Sprague-Dawley rats.

scientific article

Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence

scientific article

Chromosomal instability in ulcerative colitis is related to telomere shortening

scientific article published on 23 September 2002

Clinical and pathological factors associated with colorectal cancer at the upper extreme of life

scientific article

Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate

scientific article published in Journal of Biological Chemistry

Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer

scientific article published on June 2012

Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

scientific article published on 02 October 2020

Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?

scientific article published on March 2014

Current targeted therapies in the treatment of advanced colorectal cancer: a review

scientific article

Decreased mitochondrial DNA mutagenesis in human colorectal cancer

scientific article

Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment

scientific article published on November 2012

Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking

scientific article published on 22 September 2017

Detection and Characterization of Hemopoietic Stem Cells in the Adult Human Small Intestine

scientific article published on 01 May 2006

Determinants of short- and long-term survival from colorectal cancer in very elderly patients

scientific article published on 18 May 2014

Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue

scientific article published on 07 November 2011

Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus

scientific article

Do Radiation-Induced Bystander Effects Correlate to the Intrinsic Radiosensitivity of Individuals and Have Clinical Significance?

scientific article published on 01 May 2009

Dysregulated bioenergetics: a key regulator of joint inflammation.

scientific article published on 24 March 2016

Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases

scientific article published in March 2013

Emerging Concepts Linking Obesity with the Hallmarks of Cancer.

scientific article published on 12 September 2016

Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells

scientific article

Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status

scientific article published on 26 July 2011

Erratum: Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

scholarly article published in British Journal of Cancer

Examining the connectivity between different cellular processes in the Barrett tissue microenvironment

scientific article published on 10 December 2015

Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma

scientific article

Extensive subclonal mutational diversity in human colorectal cancer and its significance

scientific article published on 05 December 2019

Generation of an epigenetic signature by chronic hypoxia in prostate cells

scientific article

Genomic biomarkers to improve ulcerative colitis neoplasia surveillance.

scientific article

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

scientific article published on 21 April 2013

High Clusterin Expression Correlates with a Poor Outcome in Stage II Colorectal Cancers

scientific article published on 20 January 2009

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

scientific article published on 01 August 2011

Identification of a mutation in LARS as a novel cause of infantile hepatopathy

scientific article

Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma

scientific article published on 28 October 2015

Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis

scientific article

Inhibition of Dendritic Cell Maturation by the Tumor Microenvironment Correlates with the Survival of Colorectal Cancer Patients following Bevacizumab Treatment

scientific article published on 06 June 2012

LC3B globular structures correlate with survival in esophageal adenocarcinoma

scientific article published on 12 August 2015

Levels of oxidative damage and lipid peroxidation in thyroid neoplasia

scientific article published in June 2010

Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer

scientific article published in July 2009

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

scientific article

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

scientific article published on 25 November 2011

Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects

scientific article published on 28 March 2010

Nuclear oxidative damage correlates with poor survival in colorectal cancer

scientific article published on 09 December 2008

Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells.

scientific article published on 15 February 2015

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint.

scientific article

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus ⬇️

scientific article

Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer.

scientific article published on 14 October 2016

Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer

scientific article

Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival

scientific article published on 14 March 2016

Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells.

scientific article published on August 2005

Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.

scientific article published on 18 June 2009

Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients

scientific article published in February 2013

Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding

scientific article published on 28 March 2012

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

scientific article

Synovial tissue hypoxia and inflammation in vivo

scientific article

Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus.

scientific article

Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms.

scientific article published on April 2004

Telomere length in the colon declines with age: a relation to colorectal cancer?

scientific article

The effect of green tea on oxidative damage and tumour formation in Lobund-Wistar rats

scientific article published on November 2008

The role of inflammation in cancer of the esophagus

scientific article published on 23 May 2014

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation

scientific article published on 17 June 2020

Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer

scientific article published in January 2009

Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation

scientific article published on August 2012

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

scientific article published on 01 April 2011

Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive

scientific article

Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer

scientific article

Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment.

scientific article

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