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List of works by Hiroshi Yamazaki

7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

scientific article

A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis

scientific article published on 5 October 2016

A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine

scientific article published on 4 April 2016

A new PCR-based assay amplifies the E6-E7 genes of most mucosal human papillomaviruses (HPV).

scientific article published in April 2000

A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system

scientific article published in February 1996

A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey.

scientific article

A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.

scientific article published on September 2010

A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur

scientific article published in June 2002

A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test

scientific article published in August 2002

A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles

article

Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).

scientific article

Activation and detoxication of aflatoxin B1

scientific journal article

Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.

scientific article published in January 1996

Activation of carcinogenic N-nitrosopropylamines to mutagens by lung and pancreas S9 fractions from various animal species and man.

scientific article published on May 1986

Activities of rat cytochrome P450 3A and 2C isoforms are increased in vivo by magnesium sulfate as evidenced by enhanced oxidation of bupivacaine and testosterone in liver microsomes

scientific article published in June 2006

Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling

scientific article published on 21 November 2019

Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase

scientific article published in June 1997

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

scientific article

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

scientific article published on 21 March 2014

Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

scientific article published on 28 June 2010

Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria

scientific article published on 7 November 2015

Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry

scientific article published in January 2010

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

scientific article published on 27 July 2016

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

scientific article

Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization

scientific article

Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans

scientific article published on 5 October 2014

Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition ⬇️

scientific article published on March 13, 2013

Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

scientific article

Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.

scientific article

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

scientific article published on 23 June 2010

Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects

scientific article published in January 2009

CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques

scientific article published on 06 May 2011

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

scientific article published on 9 November 2010

CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

scientific article

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

scientific article published on 15 July 2014

CYP2C76 non-synonymous variants in cynomolgus and rhesus macaques.

scientific article

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.

scientific article

CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing enzyme.

scientific article published on 28 December 2010

CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes

scientific article published on January 2013

Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes

scientific article

Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations

scientific article published on 01 October 1994

Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

scientific article

Characterization of liver microsomal 7-ethoxycoumarin O -deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene

article

Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque.

scientific article published on 19 June 2013

Clinical evidence of pharmacokinetic changes in thalidomide therapy.

scientific article

Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis).

scientific article published in December 2009

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.

scientific article published on 23 June 2016

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

scientific article published on July 1998

Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition ⬇️

scientific article published on October 1, 2012

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.

scientific article published on June 2011

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans

scientific article published on January 2010

Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal region

scientific article

Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

scientific article published on 06 May 2015

Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human

scientific article published in May 2001

Correction to "Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models"

scientific article published on 22 March 2019

Cynomolgus macaque CYP4 isoforms are functional, metabolizing arachidonic acid.

scientific article published on 19 November 2010

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

scientific article published on 25 May 2010

Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans

scientific article published on 24 June 2005

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques

scientific article published on 19 November 2018

Cytochrome P450 2A6 Phenotyping Based on Dietary Caffeine Intake in a Japanese Population of Non-smokers

scientific article published on 01 June 2012

Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.

scientific article

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

scientific article

Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans

scientific article published on January 1997

Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies

scientific article published in January 2009

Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells

scientific article published in December 2001

Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms

scientific article

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

scientific article published in November 2009

Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).

scientific article published in November 2003

Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity

scientific article published in April 1995

Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.

scientific article

Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes.

scientific article published on 17 October 2016

Different Effects of Polymorphic Flavin-containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-related Disease in a General Population in Japan

scientific article published on 09 October 2020

Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential

scientific article published on 06 December 2020

Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors

scientific article published on 10 February 2007

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

scientific article published on 31 December 2019

Different metabolites of human hepatotoxic pyrazolopyrimidine derivative 5-n-butyl-pyrazolo[1,5-a]pyrimidine produced by human, rat and monkey cytochrome P450 1A2 and liver microsomes.

scientific article published on 9 November 2011

Differential roles of cytochromes P450 2D1, 2C11, and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes

scientific article published on 01 June 1994

Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method ⬇️

scientific article published on March 21, 2011

Discovery of Genetic Variants in CYP1D1: Implication for Functional Integrity of CYP1D1 in Cynomolgus Macaques and Rhesus Macaques ⬇️

scientific article published on August 16, 2011

Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation

scientific article

Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5

scientific article

Drug-induced Liver Toxicity Studies: Research into Human Metabolites Clarifies Their Role in Drug Development

article

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

scientific article published on 13 June 2017

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

scientific article

Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor teneligliptin: an open-label study in healthy white subjects in Germany

scientific article

Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes

Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients

scientific article published on 02 December 2014

Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7.

scientific article published in December 2003

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

scientific article

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems

scientific article published in December 2009

Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes

scientific article

Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

scientific article published on 19 February 2014

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase

scientific article published on 15 October 2014

Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

scientific article

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expressi

scientific article published on April 2002

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

article

Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

scholarly article by Shotaro Uehara et al published 4 October 2018 in Xenobiotica

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

scientific article published on 25 September 2018

Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques

scientific article published on 11 November 2019

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

scientific article published on 01 March 1995

Expression of cytochromes p450 in fetal, infant, and juvenile liver of cynomolgus macaques.

scientific article published on 16 August 2011

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

scientific article

Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

scientific article

Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations

scientific article published on February 2015

Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells

scientific article published on February 2002

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

scientific article published on 02 March 2019

Functional characterization and tissue expression of marmoset cytochrome P450 2E1.

scientific article

Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes

scientific article published on 10 February 2019

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.

scientific article published on 2 January 2016

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

scientific article published on 06 December 2018

Genetic Polymorphisms of Glycine N-acyltransferase in Japanese Individuals

scientific article published on 01 January 2009

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles

scientific article published on 13 September 2018

Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.

scientific article

Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

scientific article published on 19 October 2014

Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients

scientific article published on June 2007

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

scientific article published on 12 November 2009

Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques

scientific article published on 19 August 2020

Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay

scientific article published in August 2002

Genotoxicity of carcinogenic N-nitrosopropylamine derivatives in the hepatocyte primary culture/DNA-repair test

scientific article published in November 1985

Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes

scientific article published on 19 December 2014

Hepatic expression of cytochrome P450 enzymes in non-human primate species.

scientific article published on 29 June 2017

Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig

scientific article published on 21 May 2014

Hepatocyte Nuclear Factor-1alpha Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

scientific article published on 01 June 2002

Heterotropic cooperativity in oxidation mediated by cytochrome p450.

scientific article published on June 2008

High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana

scientific article published on 20 January 2005

High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge

scientific article published on 01 April 1996

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

scientific article published on 01 January 1999

Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

scientific article published on 01 May 2020

Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.

scientific article published on 20 March 2015

Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling

scientific article published on September 2010

Human cytochrome P450 1A1 is a novel target gene of liver X receptor α.

scientific article published on 7 June 2011

Human cytochrome P450 1A2 involvement in the formation of reactive metabolites from a species-specific hepatotoxic pyrazolopyrimidine derivative, 5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine

scientific article published in February 2009

Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene.

scientific article published on 12 February 2008

Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide

scientific article published on 24 December 2013

Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers

scientific article published on 01 December 1997

Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food

scientific article

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate

scientific article published on June 2010

Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling

scientific article published on 28 January 2015

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

scientific article

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

scientific article

Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

scientific article published on 10 December 2015

Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 10 July 2014

Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate

article

Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.

scientific article published on 21 March 2015

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

scientific article

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

scientific article published on 25 November 2009

Identification of a novel polymorphic enhancer of the human CYP3A4 gene

scientific article published on February 2004

Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes

scientific article

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

scientific article

Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys

scientific article

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

scientific article

Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

scientific article

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans.

scientific article published on 18 December 2015

In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais

scientific article published on 01 December 2006

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

scientific article

In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice

scientific article published on 7 February 2011

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

scientific article

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

scientific article published on 21 September 2018

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

scientific article published on 15 July 2016

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

scientific article published on 28 September 2018

Increased distribution of carboplatin, an anti-cancer agent, to rat brains with the aid of hyperbaric oxygenation

scientific article

Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation

scientific article

Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.

scientific article published on 20 April 2016

Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5.

scientific article published on 8 February 2016

Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3.

scientific article published on 8 February 2016

Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age.

scientific article published on 23 August 2011

Individual differences in toxicological response caused by a diversity of chemicals: observations in Japan

scientific article

Inhibitory effect of organic solvents on the mutagenicity of N-nitrosodialkylamines in Salmonella

scientific article published in April 1985

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions

scientific article published on March 2000

Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.

scientific article

Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations

scientific article published on 01 December 2006

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity

scientific article published on December 2008

Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis

scientific article published on 12 July 2012

Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol

scientific article

Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.

scientific article

Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population

scientific article published on 11 August 2010

Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese population

scientific article published on 30 January 2008

Linkage between the distribution of mutations in the CYP2C18 and CYP2C19 genes in the Japanese and Caucasian

scientific article published in April 1998

Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes

scientific article published on 13 October 2020

Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.

scientific article published on 09 February 2011

Marmoset Cytochrome P450 2B6, a Propofol Hydroxylase Expressed in Liver

scientific article published on 8 February 2018

Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

scientific article

Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.

scientific article published on 3 March 2017

Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan

scientific article published on 24 March 2015

Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.

scientific article published on 22 February 2016

Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues.

scientific article published on 20 July 2016

Mechanism-based Inhibition of CYP1A1 and CYP3A4 by the Furanocoumarin Chalepensin

scientific article published on 18 December 2012

Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas

scientific article published on 15 June 2005

Mechanism‐based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo ⬇️

scientific article published on July 1, 2011

Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model

scientific article published on 16 November 2020

Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay

scientific article published in October 2001

Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.

scientific article

Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans

scientific article published on 15 July 2013

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes

scientific article published on 01 February 1994

Metabolism of P450 Probe Substrates by Cynomolgus Monkey CYP2C76

scientific article published on 14 July 2011

Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

scientific article published on 12 November 2019

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

scientific article published on October 2010

Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.

scientific article published on 18 January 2011

Mild trimethylaminuria observed in a Japanese cohort with liver damage

scientific article published in July 2005

Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort

article

Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole, or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations

scientific article published on 06 July 2020

Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase

scientific article published on 9 May 2017

Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

scholarly article by Yasuhiro Uno et al published 25 October 2018 in Chemical Research in Toxicology

Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque

scientific article published on 14 May 2019

Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.

scientific article published on 23 April 2013

Molecular cloning and tissue distribution of a novel marmoset ABC transporter

scientific article published on 23 October 2017

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

scientific article

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

scientific article published on 03 October 2012

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

scientific article published on 16 May 2013

Mutagenic Activation of 3-Methoxy-4-aminoazobenzene by Mouse Renal Cytochrome-P450 CYP4B1: Cloning and Characterization of Mouse CYP4B1 ⬇️

scientific article published on August 1, 1995

Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108.

scientific article

Mutagenicity of N-nitrosodiethanolamine in the Salmonella/microsome test

scientific article published in October 1987

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

scientific article

Nicotine metabolism and CYP2A6 allele frequencies in Koreans

scientific article published in June 2001

Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques

scientific article published on 07 September 2018

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole

scientific article published on 30 July 2015

Novel variants and haplotypes of human flavin-containing monooxygenase 3 (FMO3) gene associated with Japanese subjects suffering from trimethylaminuria

article

Oral L-carnitine supplementation increases trimethylamine-N-oxide but reduces markers of vascular injury in hemodialysis patients

scientific article

Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

scientific article published on 02 February 2015

Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes

scientific article published on 17 April 2019

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

scientific article published on 15 September 2016

Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13

scientific article published on 6 August 2015

P450 and carcinogenesis

scientific article published on 01 April 2002

Pharmacokinetic investigation of increased efficacy against malignant gliomas of carboplatin combined with hyperbaric oxygenation

scientific article published in May 2009

Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.

scientific article

Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator-activated receptor-alpha modulator, in rats and monkeys

scientific article published on 01 January 2019

Pharmacokinetics of Antifungal Agent Micafungin in Critically Ill Patients Receiving Continuous Hemodialysis Filtration

scientific article published on 01 May 2007

Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital

scientific article published on 11 September 2020

Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital

scientific article published on 11 December 2018

Phospholipase D Activity of Cytochrome P450 in Human Liver Endoplasmic Reticulum

scientific article published on 01 July 1999

Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules.

scientific article published on 7 September 2016

Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug-drug interactions in cynomolgus monkeys

scientific article

Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling

scientific article published on 12 November 2020

Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models

scientific article published on 18 December 2018

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

scientific article published on 5 February 2013

Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

scientific article published on 03 January 2020

Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.

scientific article published on 31 August 2015

Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.

scientific article published in July 2014

Polymorphisms of cytochrome P450 2B6 (CYP2B6 ) in cynomolgus and rhesus macaques

scientific article published on 22 February 2018

Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients

scientific article

Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers

scientific article published on 05 October 2014

Potential impact of cytochrome P450 3A5 in human liver on drug interactions with triazoles

scientific article published on June 2010

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

scientific article published on 7 September 2016

Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

scientific article published on 21 June 2019

Predicted Contributions of Flavin-containing Monooxygenases to the NOxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants

scientific article published on 07 December 2020

Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

scientific article published on 13 September 2019

Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

scientific article published on 12 November 2018

Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

scientific article published on 25 November 2019

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

scientific article published on 5 April 2018

Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

scientific article

Preference for O-demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes

scientific article published on 21 April 2020

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

scientific article

Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing

scientific article (publication date: 2014)

Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol

scientific article published on 8 August 2006

Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens

scientific article published in December 1992

Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects

scientific article published on 23 April 2017

Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.

scientific article

Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers

scientific article published on 11 May 2017

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

scientific article published on 14 June 2019

Regioselective hydroxylation of steroid hormones by human cytochromes P450.

scientific article

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

scientific article

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

scientific article published on May 2014

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

scientific article published on 01 July 1996

Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study

scientific article published on July 2009

Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002.

scientific article published in June 1999

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

scientific article published on 01 March 1999

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

scientific article published on 19 March 2007

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

scientific article published on 01 January 1996

Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl

scientific article published on 13 September 2016

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli

scientific article published in April 2002

Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes

scientific article published in June 1998

Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes

scientific article published on February 1998

Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

article

Sexual behaviour and high risk human papillomavirus infections in Japanese women

scientific article published in June 2005

Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

scientific article published on 8 September 2015

Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.

scientific article

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

scientific article

Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).

scientific article

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

scientific article published on 28 September 2018

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

scientific article

Sorafenib and sunitinib, two anticancer drugs, inhibit CYP3A4-mediated and activate CY3A5-mediated midazolam 1'-hydroxylation

scientific article

Species differences in hydrolase activities toward OT-7100 responsible for different bioavailability in rats, dogs, monkeys and humans

scientific article

Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds ⬇️

scientific article published on July 20, 2011

Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

scientific article published on 05 February 2019

Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase

scientific article published on 18 June 2001

Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.

scientific article

Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.

scientific article published on 3 May 2016

Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives

scientific article published on December 2010

Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6.

scientific article published on 9 April 2015

Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates

scientific article published on 18 June 2018

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.

scientific article published on 06 April 2013

Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples.

scientific article published on 27 July 2016

Systematic characterization of glutathione S-transferases in common marmosets

scientific article published on 04 February 2020

Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque.

scientific article published on July 2013

Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines.

scientific article published on 22 April 2017

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

scientific article published on 5 February 2014

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

scientific article published on 23 February 2016

The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.

scientific article published on 26 July 2017

The evaluation of genotoxic activities of disinfectants and their metabolites by umu test

scientific article published in November 1988

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

scientific article published on 25 September 2013

The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function

scientific article published on 18 November 2019

Three Novel Single Nucleotide Polymorphisms of the FMO3 Gene in a Japanese Population

article

Transient trimethylaminuria related to menstruation

scientific article

Trimethylamine generation in patients receiving hemodialysis treated with l-carnitine

scientific article

Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.

scientific article

Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese

scientific article published on 21 January 2009

Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes

scientific article published in April 2004

Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes

scientific article published in October 1992

Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.

scientific article published on 15 June 2016

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding.

scientific article published in March 2009

Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population

article

Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females

scientific article

Voriconazole metabolism, toxicity, and the effect of cytochrome P450 2C19 genotype

scientific article

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