List of works - Agustín Tortajada

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.

scholarly article

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

scientific article

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

scientific article

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

scientific article published on June 2013

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase

scientific article published on 4 November 2009

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs ⬇️

scientific article published on November 1, 2012

Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance

scientific article

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

scientific article

Factor H-related proteins determine complement-activating surfaces

scientific article published on 13 May 2015

Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene

scientific article published on August 2016

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

scientific article published on 13 January 2017

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

scholarly article

Genetics of atypical hemolytic uremic syndrome (aHUS).

scientific article

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

scientific article

Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.

scientific article

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy

scientific article

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

scientific article

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

scientific article

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

scientific article

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome

scientific article

List of works by Agustín Tortajada

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs ⬇️

Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

Factor H-related proteins determine complement-activating surfaces

Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

Genetics of atypical hemolytic uremic syndrome (aHUS).

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome