List of works - Alexander Steinle

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

scientific article published on 15 August 2018

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

scientific article published on 17 July 2019

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

scientific article published on 13 February 2013

Activation of V gamma 9V delta 2 T cells by NKG2D.

scientific article

Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.

scientific article

An Fc-optimized NKG2D-immunoglobulin G fusion protein for induction of natural killer cell reactivity against leukemia

scientific article published on 28 July 2014

Arming Cytotoxic Lymphocytes for Cancer Immunotherapy by Means of the NKG2D/NKG2D-Ligand System

scientific article published on 29 July 2020

Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity.

scientific article published on 22 April 2013

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family

scientific article (publication date: 2013)

BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia

scientific article published on April 2006

CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro

scientific article published on 01 June 2011

CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML

scientific article published on 01 November 2019

CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL–CD69–LLT1 family

scientific article published on 29 November 2007

Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80

scientific article published on 06 July 2018

Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors

scientific article published on 3 November 2017

Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium.

scientific article

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

scientific article

Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses.

scientific article

Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins

scientific article published on 30 November 2009

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

scientific article published on 01 October 2002

Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4.

scientific article published on 29 March 2018

Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity

scientific article published on 13 December 2010

Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.

scientific article

Cytotoxic T lymphocytes show HLA-C-restricted recognition of EBV-bearing cells and allorecognition of HLA class I molecules presenting self-peptides.

scientific article published on October 1992

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

scientific article

Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors

scientific article

Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain

scientific article

Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.

scientific article

Direct and natural killer cell-mediated antitumor effects of low-dose bortezomib in hepatocellular carcinoma

scientific article

Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules

scientific article

Editorial overview

scientific article published on 01 September 2011

Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands.

scientific article published on 17 November 2005

Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status.

scientific article published on 12 September 2014

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

scientific article published on 24 April 2003

Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.

scientific article published on 8 August 2013

HemITAM: A single tyrosine motif that packs a punch.

scientific article

Heterogeneity of Rearranged T Cell Receptor Vα and Vβ Gene Transcripts in Synovial Fluid T Cells of HLA-B27 Positive Reactive Arthritis Patients

article

Human Cytomegalovirus-Encoded UL16 Discriminates MIC Molecules by Their 2 Domains

scientific article published on 01 September 2006

Human hematopoietic CD34+ progenitor cells induce natural killer cell alloresponses via NKG2D activation

scientific article published on 15 October 2015

Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction

scientific article published on August 2011

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

scientific article published on 15 November 2019

In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex

scientific article published on February 1995

Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine

scientific article

Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells.

scientific article

Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells

scientific article

Isolation and characterization of a genomic HLA-Cw6 clone

scientific article published on 01 March 1992

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.

scientific article published in May 2015

MHC class I allorecognition: the likes and dislikes of CTL and NK cells.

scientific article published on July 1994

MICA/NKG2D-mediated immunogene therapy of experimental gliomas.

scientific article published on December 2003

MULT1plying cancer immunity

scientific article published in Science

Microheterogeneity in HLA-B35 alleles influences peptide-dependent allorecognition by cytotoxic T cells but not binding of a peptide-restricted monoclonal antibody

scientific article published on December 1993

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex

scientific article

Motif of HLA-B*3503 peptide ligands

scientific article published on 01 January 1996

Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

scientific article published on 22 October 2006

NK cells and cancer immunosurveillance.

scientific article published on October 2008

NKG2D-dependent anti-tumor effects of chemotherapy and radiotherapy against glioblastoma.

scientific article published on 21 November 2017

NKp80 defines and stimulates a reactive subset of CD8 T cells

scientific article published on 15 October 2008

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma.

scientific article published on 10 April 2017

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

scientific article published in July 2005

Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A.

scientific article

New prospects on the NKG2D/NKG2DL system for oncology

scientific article published on 25 October 2013

Novel APC-like properties of human NK cells directly regulate T cell activation

scientific article published on December 2004

Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729

Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

scientific article published on 27 November 2017

Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer

scientific article published on August 2004

Proteolytic release of soluble UL16-binding protein 2 from tumor cells

scientific article published in March 2006

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

scientific article

Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells

scientific article

Reinforcing natural killers

scientific article published on 01 June 2009

Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients

scientific article published on 29 March 2006

Retraction. Novel APC-like properties of human NK cells directly regulate T cell activation

scientific article published on 01 April 2015

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.

scientific article published on 20 December 2017

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

scientific article published on 18 April 2013

Soluble MICA in malignant diseases

scientific article published on 01 February 2006

Soluble MICB in malignant diseases: analysis of diagnostic significance and correlation with soluble MICA

article

Soluble NKG2D ligands in hepatic autoimmune diseases and in benign diseases involved in marker metabolism

scientific article published on 01 July 2007

Soluble NKG2D ligands: prevalence, release, and functional impact.

scientific article published on May 2008

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

scientific article published on 3 August 2006

The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk).

scientific article published on 12 January 2017

The BCR/ABL-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity

scientific article

The HLA likes and dislikes of allospecific and non-MHC-restricted cytotoxic T lymphocytes.

scientific article published on December 1996

The NKG2D axis: an emerging target in cancer immunotherapy

scientific article published on 22 February 2019

The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells

scientific article published on 7 March 2017

The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.

scientific article

The innate immune response in the central nervous system and its role in glioma immune surveillance.

scientific article

The novel deubiquitinase inhibitor b-AP15 induces direct and NK cell-mediated antitumor effects in human mantle cell lymphoma.

scientific article published on 19 March 2018

The polymorphic HCMV glycoprotein UL20 is targeted for lysosomal degradation by multiple cytoplasmic dileucine motifs.

scientific article published on 12 July 2011

Transferrin‘ activation: Bonding with transferrin receptors tunes KLRG1 function

scientific article published on 07 May 2014

Tumor-associated MICA is shed by ADAM proteases

scientific article

Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.

scientific article

Vis-à-vis in the NKC: genetically linked natural killer cell receptor/ligand pairs in the natural killer gene complex (NKC).

scientific article published on 22 March 2011

List of works by Alexander Steinle

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

Activation of V gamma 9V delta 2 T cells by NKG2D.

Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.

An Fc-optimized NKG2D-immunoglobulin G fusion protein for induction of natural killer cell reactivity against leukemia

Arming Cytotoxic Lymphocytes for Cancer Immunotherapy by Means of the NKG2D/NKG2D-Ligand System

Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity.

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family

BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia

CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro

CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML

CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL–CD69–LLT1 family

Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80

Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors

Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium.

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses.

Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4.

Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity

Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.

Cytotoxic T lymphocytes show HLA-C-restricted recognition of EBV-bearing cells and allorecognition of HLA class I molecules presenting self-peptides.

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors

Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain

Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.

Direct and natural killer cell-mediated antitumor effects of low-dose bortezomib in hepatocellular carcinoma

Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules

Editorial overview

Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands.

Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status.

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.

HemITAM: A single tyrosine motif that packs a punch.

Heterogeneity of Rearranged T Cell Receptor Vα and Vβ Gene Transcripts in Synovial Fluid T Cells of HLA-B27 Positive Reactive Arthritis Patients

Human Cytomegalovirus-Encoded UL16 Discriminates MIC Molecules by Their 2 Domains

Human hematopoietic CD34+ progenitor cells induce natural killer cell alloresponses via NKG2D activation

Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex

Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine

Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells.

Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells

Isolation and characterization of a genomic HLA-Cw6 clone

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.

MHC class I allorecognition: the likes and dislikes of CTL and NK cells.

MICA/NKG2D-mediated immunogene therapy of experimental gliomas.

MULT1plying cancer immunity

Microheterogeneity in HLA-B35 alleles influences peptide-dependent allorecognition by cytotoxic T cells but not binding of a peptide-restricted monoclonal antibody

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex

Motif of HLA-B*3503 peptide ligands

Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

NK cells and cancer immunosurveillance.

NKG2D-dependent anti-tumor effects of chemotherapy and radiotherapy against glioblastoma.

NKp80 defines and stimulates a reactive subset of CD8 T cells

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma.

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A.

New prospects on the NKG2D/NKG2DL system for oncology

Novel APC-like properties of human NK cells directly regulate T cell activation

Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729

Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer

Proteolytic release of soluble UL16-binding protein 2 from tumor cells

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells

Reinforcing natural killers

Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients

Retraction. Novel APC-like properties of human NK cells directly regulate T cell activation

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

Soluble MICA in malignant diseases

Soluble MICB in malignant diseases: analysis of diagnostic significance and correlation with soluble MICA

Soluble NKG2D ligands in hepatic autoimmune diseases and in benign diseases involved in marker metabolism

Soluble NKG2D ligands: prevalence, release, and functional impact.

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk).