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List of works by Manlio Palumbo

2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents

scientific article published in January 2002

2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction

scientific article published on June 2009

6-Aminoquinolones as new potential anti-HIV agents.

scientific article

A potentiometric and CD investigation on the conformational properties of poly(L-p-aminophenylalanine) in aqueous solution

scientific article published on 01 November 1976

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.

scientific article

Adjustable 'cross-linking' of neighboring DNA molecules in liquid-crystalline dispersions through (daunomycin-copper) polymeric chelate complexes

scientific article published on 01 December 1996

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

scientific article published on 25 September 2007

Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation

scientific article

An X-ray study of poly(L-prolyl-L-alpha-phenylglycyl-L-proline)

scientific article published on 01 March 1976

Anthracyclines: recent developments in their separation and quantitation

scientific article

Anticancer agents: towards the future.

scientific article published in September 2004

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

scientific article published on 01 February 2004

Antitumor potential of aza-bioisosterism in anthracenedione-based drugs.

scientific article published on January 2004

Antiviral 6-amino-quinolones: molecular basis for potency and selectivity

scientific article published in October 2005

Antiviral properties of psoralen derivatives: a biological and physico-chemical investigation

scientific article published on November 1984

Antiviral properties of quinolone-based drugs.

scientific article published on June 2004

Assessment of gene promoter G‑quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells

scientific article

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

scientific article published on 25 May 2012

Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity

scientific article

BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents

scientific article

Benzo- and tetrahydrobenzo-psoralen congeners: DNA binding and photobiological properties

scientific article

Benzofurocoumarins: new monofunctional DNA-photobinding agents

scientific article published on 01 July 1986

Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking

scientific article published on 16 November 2006

Bis-phenanthroline derivatives as suitable scaffolds for effective G-quadruplex recognition

scientific article published on 25 May 2010

Chromophore-modified antitumor anthracenediones: synthesis, DNA binding, and cytotoxic activity of 1,4-bis[(aminoalkyl)amino]benzo[g]-phthalazine-5,10-diones

scientific article published on 01 February 1995

Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions

scientific article published in August 2001

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.

scientific article

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage

scientific article published on 13 April 2006

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

scientific article published on 22 August 2008

Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment ⬇️

scientific article published on 06 June 2013

Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA.

scientific article published on 19 October 2004

Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops

scientific article

Conformational drug determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage

scientific article published on 01 January 1994

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

scientific article published on 01 September 1994

Conformational state of lacrimal proteins adsorbed on contact lenses

scientific article published on June 1985

Continuous mitoxantrone infusion in pretreated epithelial ovarian cancer

scientific article published on 01 January 1995

DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action

scientific article

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

scientific article published on January 2007

DNA-binding of water-soluble furocoumarins: a thermodynamic and conformational approach to understanding different biological effects.

scientific article published on November 1984

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents

scientific article published in July 2003

Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges

scientific article published in July 2004

Diethylaminopropionamido-hydroxy-anthraquinones as potential anticancer agents: synthesis and characterization

scientific article

Differential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structure

scientific article

Dinuclear Zn(2+) complexes of synthetic heptapeptides as artificial nucleases.

scientific article published in April 2001

Dissecting reactivity of clerocidin toward common buffer systems by means of selected drug analogues

scientific article published in January 2005

Do quinolones bind to DNA?

scientific article published on 01 May 1988

Effect of G-quadruplex polymorphism on the recognition of telomeric DNA by a metal complex

scientific article

Effective DNA inhibitors of cathepsin g by in vitro selection

scientific article published on 20 June 2008

Effects of calcium ions on the interactions between antithrombin and factor Xa mediated by variously sulfated, semisynthetic low-molecular-weight heparins

scientific article published in August 2002

Effects of common buffer systems on drug activity: the case of clerocidin.

scientific article

Effects of magnesium and related divalent metal ions in topoisomerase structure and function.

scientific article published on 02 February 2009

Effects of sulfation on antithrombin-thrombin/factor Xa interactions in semisynthetic low molecular weight heparins

scientific article published in October 2001

Effects of tacrine upon murine neuroblastoma cells

scientific article published on 01 January 1995

Efficient plasmid DNA cleavage by a mononuclear copper(II) complex

scientific article published in April 2005

Ferric complexes of acetoacetyl derivatives of poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyric acid). I. Preparation and absorption properties in solution

scientific article published in November 1976

Ferric complexes of acetoacetyl derivatives of poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyric acid). II. Conformational properties in solution. Evidence for a stereospecific complex formation

scientific article published on 01 November 1976

Folding versus charge: understanding selective target recognition by the thrombin aptamers.

scientific article

Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity

scientific article

G-quadruplexes in human promoters: A challenge for therapeutic applications.

scientific article

Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents

scientific article published on January 2012

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

scientific article published on 30 August 2007

In front of and behind the replication fork: bacterial type IIA topoisomerases.

scientific article published on 18 February 2010

In vitro basis for schedule-dependent interaction between gemcitabine and topoisomerase-targeted drugs in the treatment of colorectal cancer

scientific article published on May 2006

In vitro selection of DNA aptamers that bind L-tyrosinamide

scientific article

Inflammatory cytokine expression following the use of bipolar electrocoagulation, ultracision harmonic scalpel and cold knife biopsy

scientific article published on 24 April 2015

Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative

scientific article published on May 2004

Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-β1 expression in mesangial cells: biochemical and structural considerations

scientific article published on 14 April 2011

Interaction between second generation anthracyclines and DNA in the nucleosomal structure

scientific article published on May 1991

Interaction model for anthracycline activity against DNA topoisomerase II.

scientific article published in June 2004

Interaction of calcium ions with peptide hormones of the gastrin family

scientific article published on 01 November 1983

Interaction of metal ions with gastrointestinal hormones. Binding of Ca2+ to Nle11-minigastrin I

scientific article published on 01 September 1980

Interaction of metal ions with gastrointestinal hormones: binding studies of Mg++ to biologically active analogs of little gastrin and minigastrin

scientific article published on 01 July 1984

Interaction of nucleosomes with anthracycline antibiotics: relevance to anticancer activity

scientific article published on 01 May 1988

Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G.

scientific article published on 28 November 2005

Intermolecular indole-imidazolium complexes. II. Interaction of a block copolymer (L-tryptophan)n-(gamma-ethyl-DL-glutamate)m with imidazolium hydrochloride and poly(L-histidine hydrochloride).

scientific article published in January 1977

Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin ⬇️

scientific article published in October 2003

Letter: Optical activity of the charge-transfer complex between poly-L-histidine hydrochloride and indole

scientific article published on 01 February 1975

Liquid-crystalline structure of nucleic acids: effect of antracycline drugs and copper ions

scientific article published on August 1997

Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

scientific article published on May 1998

Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

scientific article published on 26 October 2009

Metal Complexes of Poly(α-amino acids). A Potentiometric and Circular Dichroism Investigation of Cu(II) Complexes of Poly(L-lysine), Poly(L-ornithine), and Poly(L-diaminobutyric acid)1 ⬇️

scientific article published on July 1, 1977

Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligands

scientific article published on 24 March 2009

Mg 2+ -mediated binding of 6-Substituted quinolones to DNA: relevance to biological activity

scientific article published on 01 September 1998

Modulation of antithrombin-protease interactions by semisynthetic low-molecular-weight heparins with different sulfation patterns

scientific article

Molecular Basis for Differential Recognition of G-Quadruplex versus Double-Helix DNA by Bis-Phenanthroline Metal Complexes.

scientific article published on 24 May 2016

Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

scientific article published on 16 June 2011

New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents

scientific article published on 01 January 2000

New anthracenedione derivatives: interaction with DNA and biological effects

scientific article published on 01 June 1983

New anthracenediones with potential anticancer activity: synthesis and characterization of bis-diethylaminopropionamido derivatives

scientific article published on September 1988

New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action

scientific article

Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

scientific article published on 7 August 2013

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

scientific article published on 17 July 2014

Novel pyrrolo[3,2-f]quinolines: synthesis and antiproliferative activity

scientific article

Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.

scientific article published on 18 January 2005

On the mechanism of action of quinolone drugs

scientific article published on 01 September 1993

On the oxy analogues to the 3 leads to 1 intramolecularly hydrogen-bonded peptide conformations

scientific article published on 01 May 1976

On the oxy analogues to the 4 leads to 1 intramolecularly hydrogen-bonded peptide conformations

scientific article published on 01 May 1976

Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity

scientific article published on 01 August 1996

Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences

scientific article published on 31 August 2008

Pharmacokinetics of intraperitoneal hyperthermic perfusion with mitoxantrone in ovarian cancer

scientific article published on 01 January 2000

Phase I–II intraperitoneal mitoxantrone in advanced pretreated ovarian cancer

scientific article published on 01 January 1993

Photobiological activity of 3,4'-dimethyl-8-methoxypsoralen, a linear furocoumarin with unusual DNA-binding properties

scientific article published on 01 September 1990

Photoreaction of psoralen derivatives with structurally organized DNA.

scientific article

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones

scientific article published on 01 January 1997

Potent 6-Desfluoro-8-methylquinolones as New Lead Compounds in Antibacterial Chemotherapy1

scientific article published on 01 December 1996

Preferred interaction of d-peptidyl-anthraquinones with double-stranded B-DNA

scientific article published on 01 December 1997

Pyrrolo-quinoline derivatives as potential antineoplastic drugs

scientific article published on 01 June 2000

Pyrrolocoumarin derivatives: DNA-binding properties

scientific article published on 01 December 1988

Quantitation of camptothecin and related compounds

scientific article (publication date: November 2001)

Quinone methide generation via photoinduced electron transfer.

scientific article

Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.

scientific article

Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone.

scientific article published on July 2010

Reactivity of clerocidin towards adenine: implications for base-modulated DNA damage

scientific article published on 23 January 2009

Relevance of DNA binding to the mechanism of anti-herpesvirus activity of benzhydrazone

scientific article published on April 1993

Relevance of ionic effects on norfloxacin uptake by Escherichia coli

scientific article published in August 1990

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.

scientific article

Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.

scientific article

Sensing biological effectors through the response of bridged nucleic acids and polynucleotides fixed in liquid-crystalline dispersions

scientific article published in March 1998

Sequence specificity of psoralen photobinding to DNA: a quantitative approach

scientific article published on December 1, 1992

Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex

scientific article

Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?

scientific article

Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting.

scientific article

Solid-state and solution conformation of N-tert-butyloxycarbonyl-L-prolylglycine

scientific article published in November 1977

Solid-state infrared absorption spectra and chain arrangement in some synthetic homooligopeptides in the intermolecularly hydrogen-bonded pleated-sheet beta-conformation

scientific article published on 01 January 1977

Somatostatin-28: a conformational analysis

scientific article published on 01 August 1981

Structural properties of hyaluronic acid in moderately concentrated solutions

scientific article published on 01 July 1986

Structure modifications of 6-aminoquinolones with potent anti-HIV activity

scientific article

Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives

scientific article published on November 2010

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

scientific article

Synthesis and conformational properties of polypeptides containing long aliphatic side chains. Poly(Nepsilon-stearyl-L-lysine) and poly(Nepsilon-pelargonyl-L-lysine)

scientific article published on 01 January 1975

Synthesis and conformational studies in solution of sequential copolypeptides: poly(L-prolyl-L-alpha-phenylglycyl-L-proline).

scientific article published in February 1975

Synthesis and photobiological properties of 4-hydroxymethyl-4'-methylpsoralen derivatives

scientific article published in October 1993

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

scientific article published on 01 January 1998

Targeting loop adenines in G-quadruplex by a selective oxirane.

scientific article published on 04 December 2012

The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein

scientific article published on March 2010

The Effects of Metal Ions on the Structure and Stability of the DNA Gyrase B Protein

scientific article published on 30 September 2005

The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids

scientific article

The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.

scientific article published on 29 April 2011

The peculiar binding properties of 4'-deoxy,4'-iododoxorubicin to isolated DNA and 175 bp nucleosomes

scientific article

The quinolone family: from antibacterial to anticancer agents

scientific article

Topoisomerase I involvement in schedule-dependent interaction between 5-fluoro-uracil and irinotecan in the treatment of colorectal cancer

scientific article published on 14 March 2009

Topoisomerase I, IIα and IIβ mRNA expression in peripheral blood mononuclear cells of patients with solid tumor: preliminary results

scientific article published on 01 May 2006

Toward efficient Zn(II)-based artificial nucleases

scientific article published in April 2004

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

scientific article published on 10 October 2006

Tuning G-Quadruplex vs Double-Stranded DNA Recognition in Regioisomeric Lysyl-Peptidyl-Anthraquinone Conjugates ⬇️

scientific article published on September 28, 2011

Tuning the activity of Zn(II) complexes in DNA cleavage: clues for design of new efficient metallo-hydrolases

scientific article published on 10 May 2008

Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA.

scientific article published on 9 January 2017

Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action.

scientific article

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