List of works - Jeroen Bakkers

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

scientific article

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function

scientific journal article

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

scientific article published on 05 December 2019

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

scientific article published on 01 October 2019

ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

scientific article

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

scientific article published on 28 May 2018

An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish

scientific article

Animal and in silico models for the study of sarcomeric cardiomyopathies

scientific article

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

scientific article published on 20 August 2019

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish

scientific article

Bmp signaling exerts opposite effects on cardiac differentiation

scientific article published on 12 January 2012

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

scientific journal article

Chitin Oligosaccharide Synthesis by Rhizobia and Zebrafish Embryos Starts by Glycosyl Transfer to O4 of the Reducing-Terminal Residue†

scientific article published in March 1999

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

article

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

scientific article published on 10 December 2021

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program

scientific article published on 01 July 2019

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo

scientific article published on 7 June 2005

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

scientific article published on 4 June 2015

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

scientific article published on 6 May 2008

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

scientific article

Dominant-negative ALK2 allele associates with congenital heart defects

scientific article

Early endocardial morphogenesis requires Scl/Tal1

scientific article (publication date: August 2007)

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

scientific article published on 18 October 2018

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

scientific article

Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in Zebrafish Embryos Disrupts Normal Developmenta,

scientific article published in April 1998

Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition

scientific article published in December 2004

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

scientific article published on 01 January 2019

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

scientific article published on 17 October 2014

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

scientific article published on September 2016

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

scientific article published on 10 August 2016

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

scholarly article

Genes in congenital heart disease: atrioventricular valve formation

scientific article published on 07 April 2008

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

scientific article published on 09 July 2019

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

scientific article

Genetics of Congenital Heart Defects: A Candidate Gene Approach ⬇️

scientific article published on May 1, 2010

Genome-wide RNA Tomography in the zebrafish embryo

scientific article published in October 2014

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

scientific article published on 18 September 2017

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

scientific article published in May 2015

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

scientific article published on February 2004

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

scientific article published on 22 March 2016

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

scientific article published on 05 January 2013

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

scientific article published on 01 September 2019

Identification and functional characterization of cardiac pacemaker cells in zebrafish

scientific article (publication date: 2012)

Identification and regulation of a molecular module for bleb-based cell motility

scientific article published on 14 June 2012

Identification of human D lactate dehydrogenase deficiency

scientific article published on 01 April 2019

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

scientific article published on 10 May 2022

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

scientific article published on 4 January 2018

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

scientific article published on 23 July 2007

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

scientific article published on 13 March 2019

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

scientific article published on 27 December 2017

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

scientific article published on 5 July 2011

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

scientific article

MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production

scientific article

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

scientific article published on 24 October 2018

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

scientific article published on July 2001

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

scientific article published on 5 October 2014

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

scientific article published on 12 February 2015

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

scientific article published on 9 April 2014

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

scientific article

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

scientific article published on 31 July 2020

On the Evolution of the Cardiac Pacemaker

scientific article

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

scientific article

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

scientific article published on 09 September 2018

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

scientific article published on 13 July 2016

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

scientific article

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

scientific article

Rhizobium Nod Factors Reactivate the Cell Cycle during Infection and Nodule Primordium Formation, but the Cycle Is Only Completed in Primordium Formation

scientific article published in October 1994

Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

scientific article published in February 2008

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis

scientific article published on 14 April 2009

Shaping up with morphogen gradients

scientific article published on 01 September 2018

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

scientific article published on 23 December 2019

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

scientific article published on 3 May 2011

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

scientific article published on 31 December 2015

Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.

scientific article

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

scientific article published on 16 July 2020

The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion

scientific article published in March 2007

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

scientific article

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

scientific article published on 01 February 2017

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

scientific article published on January 2017

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution

scientific article

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

scientific article published in October 2011

Twists and turns

scientific article published on 28 November 2017

Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish

scientific article published on 15 December 2007

UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly

scientific article

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis

scientific article

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.

scientific article

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.

scientific article published on 28 April 2011

Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points

scientific article published on 6 March 2007

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm

scientific article

Zebrafish as a model to study cardiac development and human cardiac disease ⬇️

scientific article published on May 19, 2011

Zebrafish cypher is important for somite formation and heart development

scientific article published on 4 August 2006

Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex

scientific article

Zebrafish prrx1a mutants have normal hearts

scientific article published on 23 September 2020

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish

scientific article published on 9 September 2016

List of works by Jeroen Bakkers

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish

Animal and in silico models for the study of sarcomeric cardiomyopathies

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish

Bmp signaling exerts opposite effects on cardiac differentiation

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Chitin Oligosaccharide Synthesis by Rhizobia and Zebrafish Embryos Starts by Glycosyl Transfer to O4 of the Reducing-Terminal Residue†

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

Dominant-negative ALK2 allele associates with congenital heart defects

Early endocardial morphogenesis requires Scl/Tal1

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in Zebrafish Embryos Disrupts Normal Developmenta,

Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Genes in congenital heart disease: atrioventricular valve formation

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

Genetics of Congenital Heart Defects: A Candidate Gene Approach ⬇️

Genome-wide RNA Tomography in the zebrafish embryo

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

Identification and functional characterization of cardiac pacemaker cells in zebrafish

Identification and regulation of a molecular module for bleb-based cell motility

Identification of human D lactate dehydrogenase deficiency

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

On the Evolution of the Cardiac Pacemaker

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

Rhizobium Nod Factors Reactivate the Cell Cycle during Infection and Nodule Primordium Formation, but the Cycle Is Only Completed in Primordium Formation

Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis

Shaping up with morphogen gradients

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover