List of works - Brad E. Hoffman

Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.

scientific article

Apoptosis of infiltrating T cells in the central nervous system of mice infected with Theiler's murine encephalomyelitis virus.

scientific article published in October 2003

Coaxing the liver into preventing autoimmune disease in the brain

scientific article published on October 2008

Covert warfare against the immune system: decoy capsids, stealth genomes, and suppressors

scientific article published on September 2013

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

scientific article published on 16 September 2013

Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.

scientific article

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.

scientific article published on 19 September 2017

Gene therapy research at the frontiers of viral immunology.

scientific article published on 24 May 2012

High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.

scientific article

Immunopathology of secondary-progressive multiple sclerosis

scientific article published in November 2001

Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.

scientific article

Improved Adeno-associated Viral Gene Transfer to Murine Glioma.

scientific article published on April 2013

Low cost delivery of proteins bioencapsulated in plant cells to human non-immune or immune modulatory cells.

scientific article

Muscle as a target for supplementary factor IX gene transfer

scientific article published in July 2007

Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer

scientific article published on 8 March 2011

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

scientific article

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells.

scientific article published on 3 May 2017

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

scientific article published on 28 September 2016

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B.

scientific article

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

scientific article published on 6 July 2009

Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer

scientific article published on August 2017

Reprogramming Immune Response With Capsid-Optimized AAV6 Vectors for Immunotherapy of Cancer

scientific article

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid

scientific article published on 29 March 2016

The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

scientific article published on 8 March 2017

Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity

scientific article

List of works by Brad E. Hoffman

Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.

Apoptosis of infiltrating T cells in the central nervous system of mice infected with Theiler's murine encephalomyelitis virus.

Coaxing the liver into preventing autoimmune disease in the brain

Covert warfare against the immune system: decoy capsids, stealth genomes, and suppressors

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.

Gene therapy research at the frontiers of viral immunology.

High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.

Immunopathology of secondary-progressive multiple sclerosis

Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.

Improved Adeno-associated Viral Gene Transfer to Murine Glioma.

Low cost delivery of proteins bioencapsulated in plant cells to human non-immune or immune modulatory cells.

Muscle as a target for supplementary factor IX gene transfer

Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells.

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B.

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer

Reprogramming Immune Response With Capsid-Optimized AAV6 Vectors for Immunotherapy of Cancer

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid

The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity