List of works - Mary-Ellen Harper

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction

scientific article

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism.

scientific article published on 27 August 2011

Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice

scientific article published on 03 March 2010

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

scientific article published on April 2014

Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Tea

scientific article published on 11 August 2016

Acylcarnitines: potential implications for skeletal muscle insulin resistance

scientific article

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

scientific article

Adverse Effects of β-Blocker Therapy on Weight Loss in Response to a Controlled Dietary Regimen

scientific article published on 23 October 2015

Ageing, oxidative stress, and mitochondrial uncoupling.

scientific article

Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats

scientific article published in March 1993

Atrial Fibrillation Is Associated With Impaired Atrial Mitochondrial Energetics and Supercomplex Formation in Adults With Type 2 Diabetes

scientific article published on 31 May 2018

Biochemical aspects of the uncoupling proteins: View from the chair

scientific article published on 01 June 1999

Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction

scientific article

Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response.

scientific article

Can response to dietary restriction predict weight loss after Roux-en-Y gastroplasty?

scientific article published on 8 February 2016

Cardiomyocyte‐specific Srsf3 deletion reveals a mitochondrial regulatory role

scientific article published in 2021

Cellular metabolism as a basis for immune privilege

scientific article published on 17 March 2006

Cellular redox dysfunction in the development of cardiovascular diseases

scientific article

Characterization of a novel metabolic strategy used by drug-resistant tumor cells

scientific article published in October 2002

Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model.

scientific article published on 05 July 2013

Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation

scientific article published on 6 April 2005

Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics.

scientific article

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy

scientific article

Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals

scientific article published on 6 October 2016

Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity

scientific article

Drugs and bugs: turning on the heat through UCP1 and UCP3.

scientific article

Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice.

scientific article

Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation

scientific article

Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

scientific article

Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice

scientific article published on 24 January 2006

Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase

scientific article published on 16 April 2013

Erratum to: Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

scientific article published on 01 February 2016

Erythrocyte membrane lipid alterations in undernourished cerebral palsied children during high intakes of a soy oil-based enteral formula

scientific article published in October 1990

Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export

scientific article published on 14 July 2008

FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle

scientific article published on 22 July 2009

Fasting and postprandial total ghrelin remain unchanged after short-term energy restriction

scientific article

Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to brown adipose tissue.

scientific article published on 27 December 2016

Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle

scientific article

Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

scientific article

Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity

scientific article

Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents

scientific article

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

scientific article published in Nature Communications

Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase

scientific article published on 12 March 2010

Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.

scientific article

Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3.

scientific article published on 22 April 2011

Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics

scientific article published on 12 October 2012

Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

scientific article

Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

scientific article published in July 2011

Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay

scientific article published on 16 September 2015

Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle

scientific article

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

scientific article

Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity

scientific article

Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin

scientific article (publication date: 2014)

In utero Undernutrition Programs Skeletal and Cardiac Muscle Metabolism

scientific article

Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes

scientific article published on 16 May 2013

Increased susceptibility to oxidative damage in post-diabetic human myotubes

scientific article published on 16 August 2009

Influence of mitochondrial membrane fatty acid composition on proton leak and H2O2 production in liver

scientific article published in January 2005

Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform

scientific article published on 20 September 2012

Jean Himms-Hagen, D.Phil. (1933–2021): Pioneering research in brown adipose tissue thermogenesis

scientific article published in 2022

KATP channel deficiency in mouse FDB causes an impairment of energy metabolism during fatigue

scientific article published on 3 August 2016

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury

scientific article

Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria

scientific article

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

scientific article

Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

scientific article published on 23 November 2004

Long-term high-fat feeding induces greater fat storage in mice lacking UCP3.

scientific article

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

scientific article

Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice

scientific article

Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans

scientific article

MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

scientific article published on 05 May 2020

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis

scientific article

Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabeticdb/dbmice

scientific article published on 01 April 2007

Metabolic terminology: what's in a name?

scientific article published on 01 June 2020

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16

scientific article

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

scientific article published on 25 May 2016

Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins.

scientific article published on 15 May 2012

Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy

scientific article published on 15 February 2016

Mitochondrial uncoupling as a target in the treatment of obesity.

scientific article

Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production

scientific article published on 11 June 2013

Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation

scientific article

Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats

scientific article

Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes

scientific article published on 15 May 2010

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

scientific article

Overexpression of UCP-3 in Skeletal Muscle of Mice Results in Increased Expression of Mitochondrial Thioesterase mRNA

scientific article published on 01 May 2001

Oxidative status of muscle is determined by p107 regulation of PGC-1alpha.

scientific article

Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice

scientific article published in December 2004

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

scientific article

Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin

scientific article published on 01 May 1995

Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

scientific article published on 08 October 2020

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

scientific article published on 28 September 2020

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha

scientific article published in November 2005

Reactive Oxygen Species and Oxidative Stress in Obesity-Recent Findings and Empirical Approaches

scientific article published on November 2016

Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats

scientific article

Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle

scientific article published on 12 December 2003

Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4

scientific article published on November 2008

Restriction of energy intake, energy expenditure, and aging.

scientific article

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes

scientific article

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

scientific article published on 17 October 2011

SirT1 regulates energy metabolism and response to caloric restriction in mice

scientific article

Skeletal muscle mitochondrial energetics in obesity and type 2 diabetes mellitus: Endocrine aspects ⬇️

scientific article published on July 26, 2012

Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3

scientific article published on 16 January 2019

Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia.

scientific article

Targeted disruption of the beta 3-adrenergic receptor gene

scientific article published in December 1995

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function ⬇️

scientific article published on February 1, 2011

The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome

scientific article published on 2 December 2013

The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals

scientific article published on 01 October 2005

The efficiency of cellular energy transduction and its implications for obesity

scientific article published on January 2008

The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis

scientific article published on 11 January 2005

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity

scientific article

UCP3 and its putative function: consistencies and controversies.

scientific article

Unchanged fasting and postprandial adiponectin levels following a 4-day caloric restriction in young healthy men.

scientific article published in April 2004

Uncoupling protein-3: clues in an ongoing mitochondrial mystery.

scientific article published on 3 January 2007

Uncoupling proteins and the control of mitochondrial reactive oxygen species production ⬇️

scientific article published on June 24, 2011

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

scientific article published on 10 October 2013

Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis

scientific article published on March 1995

β3-Adrenergic Receptors on White and Brown Adipocytes Mediate β3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake

scientific article published in Journal of Biological Chemistry

List of works by Mary-Ellen Harper

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism.

Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Tea

Acylcarnitines: potential implications for skeletal muscle insulin resistance

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

Adverse Effects of β-Blocker Therapy on Weight Loss in Response to a Controlled Dietary Regimen

Ageing, oxidative stress, and mitochondrial uncoupling.

Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats

Atrial Fibrillation Is Associated With Impaired Atrial Mitochondrial Energetics and Supercomplex Formation in Adults With Type 2 Diabetes

Biochemical aspects of the uncoupling proteins: View from the chair

Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction

Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response.

Can response to dietary restriction predict weight loss after Roux-en-Y gastroplasty?

Cardiomyocyte‐specific Srsf3 deletion reveals a mitochondrial regulatory role

Cellular metabolism as a basis for immune privilege

Cellular redox dysfunction in the development of cardiovascular diseases

Characterization of a novel metabolic strategy used by drug-resistant tumor cells

Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model.

Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation

Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics.

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy

Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals

Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity

Drugs and bugs: turning on the heat through UCP1 and UCP3.

Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice.

Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation

Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice

Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase

Erratum to: Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

Erythrocyte membrane lipid alterations in undernourished cerebral palsied children during high intakes of a soy oil-based enteral formula

Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export

FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle

Fasting and postprandial total ghrelin remain unchanged after short-term energy restriction

Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to brown adipose tissue.

Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle

Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity

Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase

Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.

Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3.

Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics

Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay

Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity

Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin

In utero Undernutrition Programs Skeletal and Cardiac Muscle Metabolism

Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes

Increased susceptibility to oxidative damage in post-diabetic human myotubes

Influence of mitochondrial membrane fatty acid composition on proton leak and H2O2 production in liver

Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform

Jean Himms-Hagen, D.Phil. (1933–2021): Pioneering research in brown adipose tissue thermogenesis

KATP channel deficiency in mouse FDB causes an impairment of energy metabolism during fatigue

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury

Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

Long-term high-fat feeding induces greater fat storage in mice lacking UCP3.

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice

Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans

MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis

Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabeticdb/dbmice

Metabolic terminology: what's in a name?

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins.

Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy

Mitochondrial uncoupling as a target in the treatment of obesity.

Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production

Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation