List of works by Marco Siccardi

A HPLC-MS method for the simultaneous quantification of fourteen antiretroviral agents in peripheral blood mononuclear cell of HIV infected patients optimized using medium corpuscular volume evaluation.

scientific article published on 10 November 2010

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication

scientific article

A simple and fast method for quantification of ertapenem using meropenem as internal standard in human plasma in a clinical setting.

scientific article published in February 2008

A simple and sensitive assay for determining plasma tipranavir concentration in the clinical setting by new HPLC method

scientific article published on 07 November 2006

A validated high-performance liquid chromatography-ultraviolet method for quantification of the CCR5 inhibitor maraviroc in plasma of HIV-infected patients.

scientific article published in February 2010

An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients

scientific article published in December 2008

Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro-in vivo correlation

scientific article

Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.

scientific article published on 15 April 2015

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

scientific article published on January 2012

Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

scientific article published on November 2008

Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles

scientific article published on 8 September 2015

Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study.

scientific article published on 16 April 2015

CYP2B6 516G>T (rs3745274) and smoking status are associated with efavirenz plasma concentration in a Serbian cohort of HIV patients.

scientific article

CYP3A4*22 (c.522-191 C>T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults.

scientific article published in September 2014

Ceftriaxone bone penetration in patients with septic non-union of the tibia

scientific article published on 15 April 2011

Class-specific relative genetic contribution for key antiretroviral drugs

scientific article published on 28 July 2015

Clinically significant drug interaction between tipranavir-ritonavir and phenobarbital in an HIV-infected subject

scientific article

Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor

scientific article

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

scientific article published on 29 June 2011

Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics

scientific article published in July 2012

Development and validation of a simultaneous extraction procedure for HPLC-MS quantification of daptomycin, amikacin, gentamicin, and rifampicin in human plasma

scientific article published on 9 November 2009

Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices

scientific article published on 9 September 2016

Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS.

scientific article published on 17 October 2014

Development, validation, and routine application of a high-performance liquid chromatography method coupled with a single mass detector for quantification of itraconazole, voriconazole, and posaconazole in human plasma.

scientific article published on 7 June 2010

Divalent metals and pH alter raltegravir disposition in vitro

scientific article

Efavirenz in an obese HIV-infected patient – a report and an in vitro–in vivo extrapolation model indicate risk of underdosing

article

Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of HIV patients by a coulter counter to determine intracellular drug concentrations.

scientific article

Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions

Glycopeptide bone penetration in patients with septic pseudoarthrosis of the tibia.

scientific article published in January 2008

HPLC-MS method for the quantification of nine anti-HIV drugs from dry plasma spot on glass filter and their long term stability in different conditions

scientific article published on 25 February 2010

HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients.

scientific article published on 7 October 2007

Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults

scientific article

Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations.

scientific article published in April 2010

Influence of CYP2B6 and ABCB1 SNPs on nevirapine plasma concentrations in Burundese HIV-positive patients using dried sample spot devices.

scientific article

Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals

scientific article

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter

scientific article

Intracellular accumulation of ritonavir combined with different protease inhibitors and correlations between concentrations in plasma and peripheral blood mononuclear cells

scientific article published on 5 December 2012

Intrapatient and Interpatient Pharmacokinetic Variability of Raltegravir in the Clinical Setting

Lack of interaction between raltegravir and cyclosporin in an HIV-infected liver transplant recipient.

scientific article published on 29 July 2009

Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism

scientific article published on December 2010

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry

scientific article

Nanomedicines for HIV therapy

scientific article

Negative predictive value of IL28B, SLC28A2, and CYP27B1 SNPs and low RBV plasma exposure for therapeutic response to PEG/IFN-RBV treatment.

scientific article published on December 2012

Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

scientific article published on 15 December 2011

Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling

scientific article

Pharmacokinetic and pharmacodynamic analysis of efavirenz dose reduction using an in vitro-in vivo extrapolation model

scientific article published on 18 July 2012

Pharmacokinetics of lamivudine and lamivudine-triphosphate after administration of 300 milligrams and 150 milligrams once daily to healthy volunteers: results of the ENCORE 2 study

scientific article published on 19 December 2011

Pharmacokinetics of switching unboosted atazanavir coadministered with tenofovir disoproxil fumarate from 400 mg once daily to 200 mg twice daily in HIV-positive patients

article

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

scientific article published on June 2015

Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

scientific article

Predicting intestinal absorption of raltegravir using a population-based ADME simulation

scientific article

Prediction of drug-drug interactions between various antidepressants and efavirenz or boosted protease inhibitors using a physiologically based pharmacokinetic modelling approach

scientific article published in July 2013

Prophylactic Drug Monitoring of Itraconazole in an Oncohematological Pediatric Patient Population

scientific article published on 01 October 2012

Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir

scientific article

Raltegravir penetration in seminal plasma of healthy volunteers

scientific article published on 22 March 2010

Ribavirin pharmacokinetics and interleukin 28B plus cytochrome P450 27B1 single-nucleotide polymorphisms as predictors of response to pegylated interferon/ribavirin treatment in patients infected with hepatitis C virus genotype 1/4.

scientific article published in December 2011

Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro

scientific article published on 03 September 2013

Simulation of the impact of rifampicin on once-daily darunavir/ritonavir pharmacokinetics and dose adjustment strategies: a population pharmacokinetic approach.

scientific article

Simultaneous quantification of linezolid, rifampicin, levofloxacin, and moxifloxacin in human plasma using high-performance liquid chromatography with UV.

scientific article

Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study).

scientific article published on 14 July 2015

The use of trough ribavirin concentration to predict sustained virological response and haematological toxicity in HIV/HCV-co-infected patients treated with ribavirin and pegylated interferon

scientific article published on 31 January 2008

Tipranavir (TPV) genotypic inhibitory quotient predicts virological response at 48 weeks to TPV-based salvage regimens.

scientific article

Unexpected drug–drug interaction between tipranavir/ritonavir and enfuvirtide

scientific article published on 01 October 2006

Use of in vitro to in vivo extrapolation to predict the optimal strategy for patients switching from efavirenz to maraviroc or nevirapine.

scientific article published in January 2015

Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots.

scientific article published on 24 June 2015

Validation of Computational Approaches for Antiretroviral Dose Optimization

scientific article published on 4 April 2016

Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds

scientific article published on 9 April 2010

Validation of liquid/liquid extraction method coupled with HPLC-UV for measurement of ribavirin plasma levels in HCV-positive patients

scientific article published on 29 March 2006

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