List of works - David A Harris

A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes

scientific article

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

scientific article published on 27 November 2010

A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells ⬇️

scientific article published on October 13, 1995

A Neuronal Culture System to Detect Prion Synaptotoxicity

scientific article

A Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons

scientific article published in Journal of Biological Chemistry

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

scientific article

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

scientific article published in June 1994

A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death

scientific article

A murine model of a familial prion disease.

scientific article

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

scientific article published on February 2013

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

scientific article published on 24 October 2011

A nine amino acid domain is essential for mutant prion protein toxicity

scientific article

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

scientific article

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

scientific article published on 01 July 1993

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity ⬇️

scientific article published on September 1, 1991

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

scientific article published on April 2001

A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells ⬇️

scientific article published on December 1, 1997

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.

scientific article

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.

scientific article published on 08 August 2008

Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.

scientific article published on December 2008

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

scientific article published on 28 January 2013

An inter-domain regulatory mechanism controls toxic activities of PrPC.

scientific article published on 29 September 2017

Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: evidence for a possible role of actin filaments

scientific article

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

scientific article

Biosynthesis and cellular processing of the prion protein.

scientific article

Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells

scientific article published on 01 August 1997

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

scientific article published on 01 March 2000

Brevin, a serum protein that acts on the barbed end of actin filaments

scientific article published on 01 December 1983

Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes

scientific article published on 16 April 2004

Cellular and transgenic models of familial prion diseases.

scientific article published on January 2001

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

scientific article

Characterization of brevin, a serum protein that shortens actin filaments.

scientific article

Cloning of non-polyadenylated RNAs from rat brain.

scientific article published in April 1991

Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi

scientific article published in October 2003

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

scientific article published on 4 January 2005

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

scientific article published in Nature

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax

scientific article published on 14 June 2007

Fishing for prion protein function

scientific article

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice

scientific article published in August 2004

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

scholarly article

Identification of Anti-prion Compounds using a Novel Cellular Assay.

scientific article published on November 2016

Identification of anti-prion drugs and targets using toxicity-based assays

scientific article published on 23 January 2019

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells

scientific article published on 01 April 1997

Immunopurification of pathological prion protein aggregates

scientific article

Ion channels induced by the prion protein: mediators of neurotoxicity.

scientific article published in January 2012

Localization of the mRNA for a chicken prion protein by in situ hybridization

scientific article

Mammalian prion protein suppresses Bax-induced cell death in yeast

scientific journal article

Mechanisms of prion-induced neurodegeneration.

scientific article published on 8 April 2016

Molecular distinction between pathogenic and infectious properties of the prion protein

scientific article

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

scientific article published on 21 November 2007

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

scientific article published on 26 March 2003

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

scientific article published on January 1996

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

scientific article

Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection

scientific article published on 21 August 2003

N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.

scientific article

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

scientific article published on January 2007

Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells

scientific article published on 01 July 2000

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

scientific article published in March 2005

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

scientific article

New insights into prion structure and toxicity.

scientific article

Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.

scientific article

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

scientific article published on 27 March 2010

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons

scientific article

PrP-dependent cell adhesion in N2a neuroblastoma cells.

scientific article

Prion diseases.

scientific article published in July 2000

Prion neurotoxicity

scientific article published on 17 January 2019

Prion neurotoxicity: insights from prion protein mutants

scientific article published on 18 September 2009

Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection

scientific article published on 21 June 2014

Prion protein at the crossroads of physiology and disease.

scientific article published on December 2011

Prion protein lacks robust cytoprotective activity in cultured cells

scientific article published on 21 August 2008

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

scientific article

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

scientific article published on 21 August 2009

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

scientific article published on 17 May 2007

Prions activate a p38 MAPK synaptotoxic signaling pathway

scholarly article published by Thibaut Imberdis in 2018

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

scientific article published in February 1993

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

scientific article published in The Lancet

Studies on the mechanism of fast axoplasmic transport using microinjection into single giant neurons

scientific article published on 01 January 1982

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

scientific article

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

scientific article

Synthetic Prions Provide Clues for Understanding Prion Diseases.

scientific article published on 6 February 2016

Targeting the cellular prion protein to treat neurodegeneration.

scientific article published in September 2012

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

scientific article published on 01 June 1995

The N-terminal, polybasic region is critical for prion protein neuroprotective activity

scientific article

The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

scientific article

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

scientific article

The cellular prion protein (PrP(C)): its physiological function and role in disease

scientific article

The neuroprotective effect of Klotho is mediated via regulation of members of the redox system

scientific article

The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.

scientific article published in January 2005

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells

scientific article

Trafficking, turnover and membrane topology of PrP.

scientific article published on January 2003

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.

scientific article published on May 1996

Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein.

scientific article published in June 2005

List of works by David A Harris

A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells ⬇️

A Neuronal Culture System to Detect Prion Synaptotoxicity

A Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death

A murine model of a familial prion disease.

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

A nine amino acid domain is essential for mutant prion protein toxicity

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity ⬇️

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells ⬇️

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.

Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

An inter-domain regulatory mechanism controls toxic activities of PrPC.

Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: evidence for a possible role of actin filaments

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

Biosynthesis and cellular processing of the prion protein.

Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

Brevin, a serum protein that acts on the barbed end of actin filaments

Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes

Cellular and transgenic models of familial prion diseases.

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

Characterization of brevin, a serum protein that shortens actin filaments.

Cloning of non-polyadenylated RNAs from rat brain.

Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax

Fishing for prion protein function

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

Identification of Anti-prion Compounds using a Novel Cellular Assay.

Identification of anti-prion drugs and targets using toxicity-based assays

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells

Immunopurification of pathological prion protein aggregates

Ion channels induced by the prion protein: mediators of neurotoxicity.

Localization of the mRNA for a chicken prion protein by in situ hybridization

Mammalian prion protein suppresses Bax-induced cell death in yeast

Mechanisms of prion-induced neurodegeneration.

Molecular distinction between pathogenic and infectious properties of the prion protein

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection

N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

New insights into prion structure and toxicity.

Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons

PrP-dependent cell adhesion in N2a neuroblastoma cells.

Prion diseases.

Prion neurotoxicity

Prion neurotoxicity: insights from prion protein mutants

Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection

Prion protein at the crossroads of physiology and disease.

Prion protein lacks robust cytoprotective activity in cultured cells

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

Prions activate a p38 MAPK synaptotoxic signaling pathway

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

Studies on the mechanism of fast axoplasmic transport using microinjection into single giant neurons

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.