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List of works by Harald H Sitte

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function

scientific article published on 15 December 2014

A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System.

scientific article

A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)

scientific article published on 26 February 2015

A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content

scientific article published on 3 December 2012

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter

scientific article published on 8 September 2014

A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes

scientific article published on 22 September 2015

A membrane network of receptors and enzymes for adenine nucleotides and nucleosides.

scientific article

A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities

scientific article

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter

scientific article published on 13 April 2015

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

scientific article

Actovegin®: a biological drug for more than 5 decades ⬇️

scientific article published on February 1, 2011

Additive gene-environment effects on hippocampal structure in healthy humans

scientific article

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters

scientific article published on December 2013

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

scientific article published on May 2015

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

scientific article published on 24 June 2013

Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cells

scientific article published on 01 January 1999

Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action

Amphetamines, new psychoactive drugs and the monoamine transporter cycle.

scientific article published on 23 December 2014

An electrophoretic approach to screen for glutamine deamidation.

scientific article published on 26 May 2012

An unsuspected role for organic cation transporter 3 in the actions of amphetamine

scientific article published on 06 April 2018

Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence

scientific article published on 30 September 2016

Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.

scientific article

Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum

scientific article published in April 2014

Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1

scientific article

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

scientific article

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome.

scientific article published on 9 July 2012

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.

scientific article published in August 2006

Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter.

scientific article published on September 1998

Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study.

scientific article

Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.

scientific article

Cooperativity between individual transporter protomers: new data fuelling old complexes

scientific article published on 15 March 2015

DARK Classics in Chemical Neuroscience: Aminorex Analogues

scientific article published on 05 October 2018

Dephosphorylation of human dopamine transporter at threonine 48 by protein phosphatase PP1/2A up-regulates transport velocity

scientific article published on 26 December 2018

Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A.

scientific article

Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

scientific article published on 19 January 2017

Dopamine Transporter Phosphorylation Site Threonine 53 Regulates Substrate Reuptake and Amphetamine-stimulated Efflux ⬇️

scientific article published on June 21, 2012

Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications

scientific article published on 14 October 2016

Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate-independent manner

scientific article published on 31 January 2019

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

scientific article published on 6 June 2018

Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact

scientific article published on 04 March 2020

Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

scientific article published on 26 October 2015

Enhanced serotonin transporter function during depression in seasonal affective disorder

scientific article published on 19 September 2007

Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates

scientific article

Fluorescence resonance energy transfer in the study of cancer pathways

scientific article

Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family

scientific article published on 6 October 2017

GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.

scientific article published on 14 March 2008

Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation

scientific article published on 2 January 2008

Glycine transporter dimers: evidence for occurrence in the plasma membrane

scientific article published on 5 February 2008

Guidelines for vaccination of immunocompromised individuals

scientific article published on 25 July 2016

Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.

scientific article published in November 2017

Human brain dopamine metabolism in levodopa-induced dyskinesia and wearing-off

scientific article published in June 2004

Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter.

scientific article

Imaging genetics of mood disorders.

scientific article published on 13 February 2010

Impact of oligomerization on the function of the human serotonin transporter.

scientific article

In vivo amphetamine action is contingent on αCaMKII

scientific article

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

scientific article published on 20 August 2020

Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling.

scientific article

Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8.

scientific article

Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.

scientific article published in February 2008

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment

scientific article published on 08 May 2011

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction

scientific article

Making Sense of: Sensitization in Schizophrenia

scientific article

Membrane localization is critical for activation of the PICK1 BAR domain

scientific article published on 8 May 2008

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

scientific article published on 24 July 2013

Methamphetamine ("crystal meth") causes induction of DNA damage and chromosomal aberrations in human derived cells

scientific article published on 22 March 2019

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

scientific article

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model

scientific article

Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

scientific article published on 2 October 2010

Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.

scientific article published on 9 September 2002

N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.

scientific article published on 4 February 2008

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

scientific article published on 22 December 2015

Oligomer formation by Na+-Cl--coupled neurotransmitter transporters.

scientific article published on October 2003

Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

scientific article

Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II

scientific article

On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study

scientific article published on 08 January 2020

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

scientific article

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.

scientific article

Pairwise structural comparison of tiagabine analogs gives new insights into their protein binding modes.

scientific article published on 22 March 2013

Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies

scientific article published on 4 March 2008

Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs

scientific article published on 21 November 2012

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters.

scientific article published on 08 July 2016

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3

scientific journal article

Platelet serotonin transporter function predicts default-mode network activity

scientific article

Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products

scientific article published on 17 October 2012

Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.

scientific article published on 27 October 2011

Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling

scientific article published on 12 June 2013

Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion

scientific article published in May 2001

Reduced default mode network suppression during a working memory task in remitted major depression

scientific article published on 6 March 2015

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site

scientific article published on 20 October 2015

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

scientific article published on 20 December 2007

SLC6 transporter oligomerization

scientific article published on 07 August 2020

Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.

scientific article

Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.

scientific article published in November 2008

Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia?

scientific article published on 20 July 2007

Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines

scientific article published on 26 September 2005

Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation

scientific article

Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif

scientific article published on 19 February 2008

Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.

scientific article published on 06 January 2014

Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking

scientific article published on February 2004

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

scientific article published on 12 February 2019

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

scientific article

Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters

scientific article published on 30 December 2019

Substantial loss of substrate by diffusion during uptake in HEK-293 cells expressing neurotransmitter transporters.

scientific article

Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy

scientific article published on 15 September 2009

Sustained dopamine release induced by secretoneurin in the striatum of the rat: a microdialysis study

scientific article published on 01 August 1995

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C

scientific article published on 3 January 2013

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers.

scientific article

The Environment Shapes the Inner Vestibule of LeuT.

scientific article

The N terminus of monoamine transporters is a lever required for the action of amphetamines

scientific article

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking ⬇️

scientific article published on September 28, 2011

The conservative view: is it necessary to implant a stent into the dopamine transporter?

scientific article published on 13 May 2014

The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.

scientific article published on 9 March 2006

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization

scientific article published on 15 November 2011

The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze

scientific article

The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein

scientific article published on 31 December 2007

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

scientific article

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization

scientific journal article

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters

scientific article

The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.

scientific article

The role of zinc ions in reverse transport mediated by monoamine transporters.

scientific article

The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.

scientific article

The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport

scientific article

Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane

scientific article

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

scientific article published on 28 September 2016

Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter

scientific article published on June 2000

Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1)

scientific journal article

Unifying concept of serotonin transporter-associated currents

scientific article published on 9 November 2011

Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter

scientific article published on 9 September 2004

para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter

scientific article published on 24 April 2019

α-Fluorination of carbonyls with nucleophilic fluorine

scientific article published on 04 March 2019

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