List of works by Nobuhiro Nishiyama

3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells

scientific article published on 12 February 2009

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

scientific article published on 16 May 2016

A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles

scientific article published on 30 August 2008

Accelerated polymer-polymer click conjugation by freeze-thaw treatment

scientific article published on 10 July 2012

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

scientific article published on 23 October 2011

Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response.

scientific article published on 29 April 2013

Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors.

scientific article

An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials.

scientific article published on 7 March 2018

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

scientific article

Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

scientific article

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

scientific article

Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation

scientific article published on 03 August 2012

Bioresponsive polymer-based nucleic acid carriers

scientific article

Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression

scientific article published on March 2004

Block copolymer hybrid calcium phosphate micelles for cancer diagnosis and neutron capture therapy

scientific article published on 19 August 2015

Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor.

scientific article

Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

scientific article published on 14 March 2016

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.

scientific article published on January 2009

Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system

scientific article

Comprehensive analysis of syndromic hearing loss patients in Japan

scientific article published on 19 August 2019

Corrigendum to “SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)” [J. Control. Release, Volume 169 (2013) 220–227]

scientific article published in March 2014

Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.

scientific article

Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo

scientific article published on 12 June 2011

Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas

scientific article

Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy.

scientific article published on April 2009

Development of polymeric micelles for targeting intractable cancers

scientific article

Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles

scientific article published in March 2003

Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy

scientific article published on 16 June 2011

Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA.

scientific article

Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice.

scientific article published on 20 July 2015

Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging.

scientific article published on 6 August 2011

Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers.

scientific article published on 25 May 2018

Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines

scientific article published on 24 August 2011

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination.

scientific article

Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles.

scientific article

Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components

scientific article

Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132

scientific article published on 14 March 2016

Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties.

scientific article published in September 2010

Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor

scientific article

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

scientific article

Enhanced transfection with silica-coated polyplexes loading plasmid DNA.

scientific article published on 20 March 2010

Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

scientific article

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

scientific article published on 31 March 2016

Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers

scientific article published on 23 December 2011

Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles.

scientific article published on 8 April 2014

Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging

scientific article

Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.

scientific article published in November 2004

Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo

scientific article

Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo

scientific article published in December 2011

General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.

scientific article published on 13 May 2015

Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy

scientific article published on 11 June 2015

Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors.

scientific article published on 6 November 2013

Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.

scientific article published on January 2011

In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent

scientific article

Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers.

scientific article published on 14 January 2016

Intracellular Delivery of Charge-Converted Monoclonal Antibodies by Combinatorial Design of Block/Homo Polyion Complex Micelles.

scientific article published on 21 December 2015

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown.

scientific article published on 30 March 2010

Iron Chelation Cancer Therapy Using Hydrophilic Block Copolymers Conjugated with Deferoxamine

scientific article published on 07 August 2020

Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells

scientific article published on March 2004

Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy

scientific article published on 01 January 2003

Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy

scientific article

Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs

scientific article published on 23 July 2011

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells

scientific article published on 13 May 2015

Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection.

scientific article

Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficient in vivo photodynamic therapy

scientific article published on 14 January 2014

Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles

scientific article

POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss

scientific article

Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.

scientific article published on 11 May 2012

Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors

scientific article published on 3 October 2013

Poly( N-isopropylacrylamide)-Based Polymer-Inducing Isothermal Hydrophilic-to-Hydrophobic Phase Transition via Detachment of Hydrophilic Acid-Labile Moiety

scientific article published on 02 January 2019

Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells

scientific article published on 08 August 2018

Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism

scientific article published on 22 January 2020

Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer.

scientific article published on December 2003

Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy.

scientific article

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.

scientific article published on 7 August 2010

Polyion complex vesicles for photoinduced intracellular delivery of amphiphilic photosensitizer.

scientific article published on 26 December 2013

Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.

scientific article published on 3 February 2012

Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation

scientific article

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

scientific article published on 6 October 2010

Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles

scientific article published on 22 August 2014

Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core

scientific article published in July 2001

Pyruvate Responsiveness Based on α-Oxohydrazone Formation for Intracellular siRNA Release from Polyion Complex-Based Carriers

scientific article published on 23 May 2019

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses.

scientific article

Ring-Fused Firefly Luciferins: Expanded Palette of Near-Infrared Emitting Bioluminescent Substrates

scientific article published on 04 February 2020

SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes).

scientific article published on 29 March 2013

Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.

scientific article

Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA.

scientific article published on 17 October 2012

Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG

scientific article published on 08 August 2012

Smart polymeric micelles for gene and drug delivery.

scientific article published on January 2005

Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy.

scientific article

Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing.

scientific article published in October 2004

Supramolecular nanodevices: from design validation to theranostic nanomedicine.

scientific article published on 14 July 2011

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

scientific article

Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles

scientific article published on 15 January 2014

Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.

scientific article published on 2 December 2015

Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection.

scientific article

Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

scientific article published on 25 June 2013

Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer

scientific article published on 2 April 2014

Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.

scientific article published on 17 January 2013

Utility of the 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-Conjugated Polymer Systems

scientific article

Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model

scientific article published on 4 August 2010

cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis

scientific article published on 13 October 2015

siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core

scientific article

siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal pHs for Exerting Enhanced RNAi Efficacy

scientific article published on 30 November 2015

Paulina is supported by:

About Paulina

Help