List of works - Robin S. Bon

A small-molecule screening strategy to identify suppressors of statin myopathy

scientific article

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory ⬇️

scientific article published on 14 September 2018

Affimer proteins are versatile and renewable affinity reagents ⬇️

scientific article

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

scientific article

Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance

scientific article published in February 2017

Bioactivity-guided navigation of chemical space

scientific article

Biology-oriented synthesis

scientific article

ChemInform Abstract: Economical and Scalable Synthesis of 6-Amino-2-cyanobenzothiazole

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

scientific article

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

scientific article published on 9 September 2011

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

scientific article

Development of selective, potent RabGGTase inhibitors

scientific article

Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality

scientific article published on 01 November 2006

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole ⬇️

scientific article published on 13 September 2016

Efficient C2 functionalisation of 2H-2-imidazolines.

scientific article published on 8 November 2007

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

scientific article published on 23 November 2020

In pursuit of small molecule chemistry for calcium‐permeable non‐selective TRPC channels – mirage or pot of gold? ⬇️

scientific article published on October 1, 2013

Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands ⬇️

scientific article published on March 2013

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice ⬇️

scientific article published on 01 August 2018

Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

Multicomponent synthesis of 2-imidazolines.

scientific article published in April 2005

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells ⬇️

scientific article

Natural and synthetic flavonoid modulation of TRPC5 channels ⬇️

scientific article published on 13 November 2015

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

scientific article published in 2003

Pico145 - powerful new tool for TRPC1/4/5 channels

scientific article published on 11 April 2017

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels ⬇️

scientific article published on 21 March 2017

Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative

scientific article published on 06 September 2019

Probing molecular interactions with methylene blue derivatized self-assembled monolayers ⬇️

Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay

scientific article

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

scientific article

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. ⬇️

scientific article published in June 2018

Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols ⬇️

scientific article published on June 2014

Structure-guided development of selective RabGGTase inhibitors

scientific article

Synthesis of 2,6-bridged piperazine-3-ones by N-acyliminium ion chemistry

scientific article published in May 2003

Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

scientific article published on 18 October 2017

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

scientific article

List of works by Robin S. Bon

A small-molecule screening strategy to identify suppressors of statin myopathy

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory ⬇️

Affimer proteins are versatile and renewable affinity reagents ⬇️

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance

Bioactivity-guided navigation of chemical space

Biology-oriented synthesis

ChemInform Abstract: Economical and Scalable Synthesis of 6-Amino-2-cyanobenzothiazole

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

Development of selective, potent RabGGTase inhibitors

Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole ⬇️

Efficient C2 functionalisation of 2H-2-imidazolines.

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

In pursuit of small molecule chemistry for calcium‐permeable non‐selective TRPC channels – mirage or pot of gold? ⬇️

Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands ⬇️

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice ⬇️

Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

Multicomponent synthesis of 2-imidazolines.

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells ⬇️

Natural and synthetic flavonoid modulation of TRPC5 channels ⬇️

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

Pico145 - powerful new tool for TRPC1/4/5 channels

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels ⬇️

Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative

Probing molecular interactions with methylene blue derivatized self-assembled monolayers ⬇️

Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. ⬇️

Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols ⬇️

Structure-guided development of selective RabGGTase inhibitors

Synthesis of 2,6-bridged piperazine-3-ones by N-acyliminium ion chemistry

Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

Ultrafast Trap State-Mediated Electron Transfer for Quantum Dot Redox Sensing ⬇️