List of works by Raymond M. Schiffelers

A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

scientific article published on 21 June 2019

A method for quantifying cellular uptake of fluorescently labeled siRNA.

scientific article published on 30 June 2010

A role for activated endothelial cells in red blood cell clearance: implications for vasopathology

scientific article published on 18 November 2011

ADDR editorial "Biologically-inspired drug delivery systems"

scientific article published on 01 November 2016

Activity of mammalian secreted phospholipase A(2) from inflammatory peritoneal fluid towards PEG-liposomes. Early indications

scientific article published on 01 February 2001

An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs

scientific article

Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells

scientific article published on 21 February 2008

Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice

scientific article published on 7 April 2006

Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity

scientific article published on 3 December 2010

Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

scientific article published in August 2003

Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice

scientific article

Antitumor efficacy of dexamethasone-loaded core-crosslinked polymeric micelles

scientific article published on 04 October 2012

Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding.

scientific article

Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

scientific article published on March 2011

Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscesses

scientific article published on 01 March 2002

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative.

scientific article published on 30 October 2017

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

scientific article published on 14 June 2018

Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes

scientific article published on 16 April 2012

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis.

scientific article

Cetuximab treatment alters the content of extracellular vesicles released from tumor cells

scientific article published on 16 March 2016

Circulation kinetics and biodistribution of dual-labeled polymersomes with modulated surface charge in tumor-bearing mice: comparison with stealth liposomes

scientific article published on 24 July 2011

Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain

scientific article published on 16 November 2010

Comparison of pharmaceutical nanoformulations for curcumin: Enhancement of aqueous solubility and carrier retention

scientific article published on 29 April 2016

Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression

scientific article published on 5 October 2011

Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π-Π Stacking Stabilized Polymeric Micelles.

scientific article published on 6 April 2015

Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin.

scientific article published on 31 July 2010

Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines

scientific article published on 25 October 2011

Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy.

scientific article published on September 2009

Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

scientific article

Delivery of nucleic acids

scientific article published on 12 June 2007

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

scientific article published on 01 October 2018

Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α₂β₁ receptor.

scientific article

Development and characterization of liposomal formulation of bortezomib

scientific article published on 23 March 2019

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

scientific article published on 14 March 2016

Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity

scientific article published on 23 December 2010

Downregulation of EGFR by a novel multivalent nanobody-liposome platform.

scientific article published on 31 March 2010

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

scientific article published on 05 June 2019

EVpedia: a community web portal for extracellular vesicles research

scientific article

Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration

scientific article published on 26 October 2006

Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice

scientific article published on December 1998

Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis

scientific article

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.

scientific article

Endothelial cells at inflammatory sites as target for therapeutic intervention.

scientific article

Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability

scientific article published on 8 February 2010

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach

scientific article published on 26 July 2011

Exosome mimetics: a novel class of drug delivery systems

scientific article published on 16 March 2012

Extracellular vesicles as drug delivery systems: lessons from the liposome field

scientific article published on 02 August 2014

Extracellular vesicles for drug delivery.

scientific article published on 26 February 2016

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

scientific article published on 31 January 2017

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology.

scientific article

Extracellular vesicles in the circulation: are erythrocyte microvesicles a confounder in the plasma haemoglobin assay?

scientific article published on February 2013

Extracellular vesicles: potential roles in regenerative medicine

scientific article

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles.

scientific article published on 6 April 2017

Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

scientific article published on 28 November 2006

Gene silencing activity of siRNA polyplexes based on biodegradable polymers.

scientific article published on 29 November 2010

Gene silencing activity of siRNA polyplexes based on thiolated N,N,N-trimethylated chitosan.

scientific article published on 4 November 2010

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis.

scientific article published on 12 June 2012

Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro

scientific article

Hemocompatibility assessment of two siRNA nanocarrier formulations

scientific article published on 20 May 2014

Host factors influencing the preferential localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue

scientific article published in June 2001

Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies

scientific article published on 3 October 2007

ICS-283: a system for targeted intravenous delivery of siRNA

scientific article published on 01 May 2006

Identification of peptide ligands for targeting to the blood-brain barrier

scientific article

Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation

scientific article

Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes

scientific article published on 01 February 2011

In Situ Gelling Liquid Crystalline System as Local siRNA Delivery System

scientific article published on 14 March 2017

In vivo methods to study uptake of nanoparticles into the brain.

scientific article published on 07 October 2010

Inflammation as target for pharmaceutical intervention in cancer

scientific article published on 01 January 2009

Insights into maleimide-thiol conjugation chemistry: Conditions for efficient surface functionalization of nanoparticles for receptor targeting.

scientific article published on 8 March 2018

Interaction of Extracellular Vesicles with Endothelial Cells Under Physiological Flow Conditions

scientific article published in January 2017

Intercalating quaternary nicotinamide-based poly(amido amine)s for gene delivery

scientific article published on 15 August 2014

In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior

scientific article published on May 2015

Ligand-targeted liposomes directed against pathological vasculature

scientific article published in February 2002

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.

scientific article

Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma.

scientific article published on 16 September 2008

Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice

scientific article

Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation

scientific article published on 30 September 2010

Liposomal prednisolone inhibits tumor growth in a spontaneous mouse mammary carcinoma model

scientific article published on 20 October 2016

Liposomal targeting of angiogenic vasculature.

scientific article

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

scientific article

Liposome-enabled synergistic interaction of antimicrobial agents

scientific article published in February 2002

Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice.

scientific article

Liposomes as carriers for colchicine-derived prodrugs: vascular disrupting nanomedicines with tailorable drug release kinetics.

scientific article

Liposomes targeting tumour stromal cells.

scientific article published on 13 October 2010

Local release of siRNA using polyplex-loaded thermosensitive hydrogels

scientific article published on 05 May 2020

Localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue: influence of liposome characteristics

scientific article published on 01 October 1999

Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pneumonia: dependence on circulation kinetics and presence of poly(ethylene)glycol coating

scientific article

Long-circulating sterically stabilized liposomes in the treatment of infections

scientific article

MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

scientific article published on 11 May 2012

Microbubbles-Assisted Ultrasound Triggers the Release of Extracellular Vesicles

scientific article published on 25 July 2017

Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease

scientific article

Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery

scientific article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.

scientific article

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment.

scientific article

Multi-parametric assessment of the anti-angiogenic effects of liposomal glucocorticoids

scientific article published on 12 January 2011

Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis

scientific article

Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways

scientific article published on 30 August 2018

Nanomedicines for the treatment of hematological malignancies

scientific article published on 28 August 2018

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper

scientific article

Optimization of poly(amido amine)s as vectors for siRNA delivery.

scientific article published on 3 December 2010

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

scientific article published on 7 January 2016

Peptide-targeted PEG-liposomes in anti-angiogenic therapy

scientific article

Pharmaceutical prospects for RNA interference.

scientific article published on January 2004

Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA.

scientific article

Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s.

scientific article

Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

scientific article published on 23 July 2020

Polymeric carrier systems for siRNA delivery.

scientific article published on January 2012

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

scientific article published on 16 May 2020

Polyphosphate nanoparticles on the platelet surface trigger contact system activation

scientific article

Polyplexes based on cationic polymers with strong nucleic acid binding properties.

scientific article published on 8 September 2011

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics.

scientific article

Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors

scientific article published on 18 January 2011

Quantitative measurement of red cell surface protein expression reveals new biomarkers for hereditary spherocytosis

scientific article published on 10 May 2018

Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies.

scientific article published on 24 December 2009

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach.

scientific article published on 15 January 2018

Red blood cell vesiculation in hereditary hemolytic anemia

scientific article published on 13 December 2013

Red blood cell: barometer of cardiovascular health?

scientific article published on 20 February 2013

SiRNA delivery with functionalized carbon nanotubes

scientific article published on 12 February 2011

Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice.

scientific article

Squeezing for Life - Properties of Red Blood Cell Deformability.

scientific article

Synthetic delivery systems for intravenous administration of nucleic acids.

scientific article published on April 2007

Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

scientific article

Targeted delivery of anti-inflammatory agents to tumors.

scientific article published on January 2009

Targeted delivery of siRNA.

scientific article published on January 2006

Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles

scientific article published on 29 September 2011

Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice

scientific article published on 10 September 2007

Targeting epidermal growth factor receptor in tumors: from conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies.

scientific article published on 28 October 2011

Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles.

scientific article published on 16 October 2013

Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate–containing RGD peptide liposomes inhibits experimental arthritis

scientific article published on 01 April 2006

Taxol(®)-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor(®) EL.

scientific article published on 5 February 2013

The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy.

scientific article published on 22 January 2011

Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer

article by Raymond M. Schiffelers et al published 1 January 2006 in Journal of Liposome Research

Therapeutic efficacy of liposomal gentamicin in clinically relevant rat models

scientific article published on 01 February 2001

Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery.

scientific article

Thermosensitive liposomes for triggered release of cytotoxic proteins

scientific article published on 14 September 2018

Toward routine detection of extracellular vesicles in clinical samples

scientific article published on June 2014

Transporting silence: design of carriers for siRNA to angiogenic endothelium

scientific article published on 24 June 2005

Trends in polymeric delivery of nucleic acids to tumors.

scientific article published on 11 June 2013

Tumor vasculature as target for therapeutic intervention.

scientific article published on 15 October 2010

Tumour-bound RNA-laden exosomes

scientific article published on 01 August 2017

Utility of targeted glucocorticoids in cancer therapy

scientific article published on 01 January 2008

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

siRNA based approaches in medicinal chemistry and drug discovery

scientific article published on 01 January 2012

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