List of works - David C. Wedge

A community effort to create standards for evaluating tumor subclonal reconstruction

scientific article published on 09 January 2020

A comparison of Raman and FT-IR spectroscopy for the prediction of meat spoilage

A comparison of different chemometrics approaches for the robust classification of electronic nose data.

scientific article

A unified haplotype-based method for accurate and comprehensive variant calling

scientific article published on 29 March 2021

Analysis of a complete DNA-protein affinity landscape

scientific article

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scientific article

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

scientific article published on 25 September 2017

Aptamer evolution for array-based diagnostics

scientific article

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

scientific article

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

scientific article

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

scientific article published in Nature Communications

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

scholarly article published in Nature Communications

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

scientific article

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

scientific article published in 2011

Benchmarking small-variant genotyping in polyploids

scientific article published on 29 December 2021

CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches

scientific article

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

scientific article published on 15 April 2021

Clinical and biological implications of driver mutations in myelodysplastic syndromes

scientific article published on 12 September 2013

Clock-like mutational processes in human somatic cells

scientific article published on 9 November 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

scientific article

Convergent evolution to an aptamer observed in small populations on DNA microarrays

scientific article published on September 2010

DNA copy number motifs are strong and independent predictors of survival in breast cancer

scientific article published on 02 April 2020

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

scientific article published on 6 August 2015

Deciphering signatures of mutational processes operative in human cancer

scientific article

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

scientific article published on 16 March 2015

Differential and limited expression of mutant alleles in multiple myeloma

scientific article

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

scientific article published on 03 August 2016

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

scientific article

Effect of mutation order on myeloproliferative neoplasms

scientific article

Embryonal precursors of Wilms tumor

scientific article published on 01 December 2019

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scholarly article by Colin S Cooper et al published June 2015 in Nature Genetics

Erratum: Corrigendum: Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

scholarly article published in Nature Genetics

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

scientific article published on 24 November 2020

FDRAnalysis: a tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines

scientific article published on 21 February 2011

Fabrication of planar organic nanotransistors using low temperature thermal nanoimprint lithography for chemical sensor applications

scientific article published on 18 January 2010

Fast randomization of large genomic datasets while preserving alteration counts

scientific article published on September 2014

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

scientific article published on 16 June 2013

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

scientific article published on 18 May 2020

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

scientific article published in February 2012

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Genomic Evolution of Breast Cancer Metastasis and Relapse

scientific article published on August 2017

Genomic and evolutionary classification of lung cancer in never smokers

scientific article published on 06 September 2021

Genomic copy number predicts esophageal cancer years before transformation

scientific article published on 07 September 2020

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

scientific article published on 06 January 2020

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

scientific article published on 23 August 2019

Genomic patterns of progression in smoldering multiple myeloma

scientific article published in Nature Communications

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

scientific article published on January 2014

How Subclonal Modeling Is Changing the Metastatic Paradigm

scientific article published on 18 November 2016

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

scientific article published on 17 November 2008

In utero origin of myelofibrosis presenting in adult monozygotic twins

scientific article published on 30 May 2022

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

scientific article published in October 2014

Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer

article

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion

scientific article

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

scientific article (publication date: 17 May 2016)

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Multi-omic cross-sectional cohort study of pre-malignant Barrett's esophagus reveals early structural variation and retrotransposon activity

scientific article published on 17 March 2022

Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

scientific article published on 27 August 2020

Mutational processes molding the genomes of 21 breast cancers

scientific article

Mutational signatures of ionizing radiation in second malignancies

scientific article

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

scientific article published on 15 May 2014

NATURAL PRODUCTS FOR PEST MANAGEMENT

Neutral tumor evolution?

scientific article

On global-local artificial neural networks for function approximation

scientific article published in July 2006

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

scientific article published in Nature Communications

Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

scientific article published on 31 October 2017

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

scientific article published on 05 February 2020

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality

scientific article published on 24 September 2016

Phytotoxic Eremophilanes from Ligularia macrophylla

scientific article published on 29 November 2007

Predictive models for population performance on real biological fitness landscapes

scientific article

Principles of Reconstructing the Subclonal Architecture of Cancers

scientific article

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

scientific article published on 05 August 2019

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

scientific article published on 08 October 2020

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

scientific article

Rapid parallel acquisition of somatic mutations afterNPM1in acute myeloid leukaemia evolution

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

scientific article

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

scientific article

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

scientific article published on 16 April 2018

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

scientific article

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

scientific article

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

scientific article

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

scientific article published on 22 June 2015

Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity

scientific article published in 2021

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

scientific article

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma

scientific article published on 3 August 2016

The Life History of 21 Breast Cancers

The evolutionary history of lethal metastatic prostate cancer

scientific article published on April 2015

The evolutionary landscape of colorectal tumorigenesis ⬇️

scientific article published on 31 August 2018

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

scientific article published on January 2013

The landscape of cancer genes and mutational processes in breast cancer

scientific article (publication date: 16 May 2012)

The life history of 21 breast cancers

scientific article (publication date: 25 May 2012)

Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations

scholarly article by Elen Kristine Höglander published in November 2018

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

scientific article published on 4 April 2018

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

scientific article

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

scientific article

Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage

scientific article

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin

scientific article

United States Department of Agriculture-Agricultural Research Service research on natural products for pest management

scientific article

Whole exome sequencing of adenoid cystic carcinoma

scientific article published on 17 June 2013

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data

scientific article

pKa Prediction from “Quantum Chemical Topology” Descriptors

scientific article published on 01 August 2009

List of works by David C. Wedge

A community effort to create standards for evaluating tumor subclonal reconstruction

A comparison of Raman and FT-IR spectroscopy for the prediction of meat spoilage

A comparison of different chemometrics approaches for the robust classification of electronic nose data.

A unified haplotype-based method for accurate and comprehensive variant calling

A unified haplotype-based method for accurate and comprehensive variant calling

Analysis of a complete DNA-protein affinity landscape

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

Aptamer evolution for array-based diagnostics

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

Benchmarking small-variant genotyping in polyploids

CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Clock-like mutational processes in human somatic cells

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

Convergent evolution to an aptamer observed in small populations on DNA microarrays

DNA copy number motifs are strong and independent predictors of survival in breast cancer

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

Deciphering signatures of mutational processes operative in human cancer

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

Differential and limited expression of mutant alleles in multiple myeloma

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

Effect of mutation order on myeloproliferative neoplasms

Embryonal precursors of Wilms tumor

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Erratum: Corrigendum: Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

FDRAnalysis: a tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines

Fabrication of planar organic nanotransistors using low temperature thermal nanoimprint lithography for chemical sensor applications

Fast randomization of large genomic datasets while preserving alteration counts

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Genomic Evolution of Breast Cancer Metastasis and Relapse

Genomic and evolutionary classification of lung cancer in never smokers

Genomic copy number predicts esophageal cancer years before transformation

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Genomic patterns of progression in smoldering multiple myeloma

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

How Subclonal Modeling Is Changing the Metastatic Paradigm

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

In utero origin of myelofibrosis presenting in adult monozygotic twins

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

Multi-omic cross-sectional cohort study of pre-malignant Barrett's esophagus reveals early structural variation and retrotransposon activity

Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

Mutational processes molding the genomes of 21 breast cancers

Mutational signatures of ionizing radiation in second malignancies

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

NATURAL PRODUCTS FOR PEST MANAGEMENT

Neutral tumor evolution?

On global-local artificial neural networks for function approximation

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality

Phytotoxic Eremophilanes from Ligularia macrophylla

Predictive models for population performance on real biological fitness landscapes

Principles of Reconstructing the Subclonal Architecture of Cancers

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia