List of works - Miguel Prudêncio

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

scientific article published on 24 November 2020

A caged lanthanide complex as a paramagnetic shift agent for protein NMR.

scientific article

A crucial role for the C-terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle.

scientific article published on 30 July 2019

A novel type of catalytic copper cluster in nitrous oxide reductase

scientific article

A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity

scientific article

A sporozoite-based vaccination platform against human malaria

scientific article published on 24 August 2018

A toolbox to study liver stage malaria

scientific article published on 17 October 2011

Accurate long-range distance measurements in a doubly spin-labeled protein by a four-pulse, double electron-electron resonance method

scientific article published on 01 December 2008

Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center

scientific article published in March 2002

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.

scientific article published on 14 December 2017

An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria

scientific article published on 01 May 2020

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

scientific article published on 17 January 2017

Antimalarial drugs - host targets (re)visited

scientific article published on March 2006

Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites

scientific article published on 21 March 2013

Biochemical and crystallographic studies of the Met144Ala, Asp92Asn and His254Phe mutants of the nitrite reductase from Alcaligenes xylosoxidans provide insight into the enzyme mechanism

scientific article

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

scientific article

Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression

scientific article published on 10 April 2015

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

scientific article published on 21 July 2016

Click Chemistry with an Active Site Variant of Azurin

Conformation of pseudoazurin in the 152 kDa electron transfer complex with nitrite reductase determined by paramagnetic NMR.

scientific article

Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

scholarly article by Luísa Aguiar et al published 1 February 2019 in MedChemComm

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

scientific article

Developmental transition of Plasmodium sporozoites into liver-stage forms is regulated by the RNA binding protein Pumilio 2.

scientific article

Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry

scientific article

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

scientific article

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

scientific article

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

scientific article published on 3 November 2015

Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection

scientific article published on 29 October 2021

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

scientific article published on 20 September 2013

Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection

scientific article published on 13 September 2019

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

scientific article published on 12 July 2016

Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy

scientific article

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

scientific article published on 17 November 2011

Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

scientific article published on 11 May 2020

Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits

scientific article published on 29 November 2019

Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans.

scientific article

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

scientific article

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

scientific article published on September 2008

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

Illuminating the host - how RNAi screens shed light on host-pathogen interactions

scientific article published on June 2009

Imidazoquines as antimalarial and antipneumocystis agents

scientific article published on December 2009

In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites

scientific article

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

scientific article published on 5 January 2011

Infection by Plasmodium changes shape and stiffness of hepatic cells

scientific article

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

scientific article

Inhibition of Plasmodium Liver Infection by Ivermectin

scientific article

Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins

scientific article published on 21 November 2019

Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections

scientific article

Interactions of the malaria parasite and its mammalian host

scientific article published on August 2008

Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection

scientific article

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

scientific article

Long-Range-Distance NMR Effects in a Protein Labeled with a Lanthanide–DOTA Chelate

scientific article published on 01 January 2007

Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.

scientific article

Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp ⬇️

scientific article published on 5 December 2011

Met144Ala mutation of the copper-containing nitrite reductase from Alcaligenes xylosoxidans reverses the intramolecular electron transfer

scientific article published in March 2004

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

scientific article published on 07 January 2019

N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads

scientific article published on 8 January 2013

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity

scientific article published on 27 December 2013

Novel Harmicines with Improved Potency against Plasmodium

scientific article published on 23 September 2020

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities

scientific article

Novel potent metallocenes against liver stage malaria

scientific article published on 12 December 2011

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

scientific article published on 22 October 2019

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility.

scientific article

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

scientific article published on 30 January 2017

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells

scientific article published on 03 June 2009

Platinum(ii)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

scientific article published on 29 September 2017

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents

scientific article published on 01 August 2019

Primaquine homodimers as potential antiplasmodial and anticancer agents

scientific article published on 10 August 2019

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

scientific article

Purification, Characterization, and Preliminary Crystallographic Study of Copper-Containing Nitrous Oxide Reductase fromPseudomonas nautica617†

scientific article published on 01 April 2000

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

scientific article published on 23 May 2013

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

scientific article

Repurposing Drugs to Fight Hepatic Malaria Parasites

scientific article published on 28 July 2020

Research funding after COVID-19

scientific article published on 01 August 2020

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

scientific article published on 21 August 2018

Spiro-Lactams as Novel Antimicrobial Agents

scientific article published on 01 January 2020

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

scientific article published on 30 September 2013

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

scientific article published on 24 December 2018

Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides

scientific article published on 01 June 2019

Targeting host factors to circumvent anti-malarial drug resistance

scientific article published on January 2013

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.

scientific article published on 17 March 2015

Targeting the liver stage of malaria parasites: a yet unmet goal

scientific article published on 21 December 2011

Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials

scientific article published on 22 May 2014

The blue copper-containing nitrite reductase from Alcaligenes xylosoxidans: cloning of the nirA gene and characterization of the recombinant enzyme

scientific article

The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding

scientific article published in April 2005

The relevance of host genes in malaria.

scientific article published on January 2007

The silent path to thousands of merozoites: the Plasmodium liver stage

scientific article published on November 2006

To migrate or to invade: those are the options

scientific article

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

scientific article published on 08 July 2013

Transient complexes of redox proteins: structural and dynamic details from NMR studies

scientific article published in November 2004

Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio

scientific article (publication date: May 2011)

Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections

scientific article

Trypanosoma brucei infection protects mice against malaria

scientific article published on 08 November 2019

Uptake and metabolism of arginine impact Plasmodium development in the liver

scientific article

Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle

scientific article

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

scientific article

X-ray structure of a blue copper nitrite reductase at high pH and in copper-free form at 1.9 Å resolution

article

List of works by Miguel Prudêncio

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

A caged lanthanide complex as a paramagnetic shift agent for protein NMR.

A crucial role for the C-terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle.

A novel type of catalytic copper cluster in nitrous oxide reductase

A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity

A sporozoite-based vaccination platform against human malaria

A toolbox to study liver stage malaria

Accurate long-range distance measurements in a doubly spin-labeled protein by a four-pulse, double electron-electron resonance method

Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.

An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Antimalarial drugs - host targets (re)visited

Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites

Biochemical and crystallographic studies of the Met144Ala, Asp92Asn and His254Phe mutants of the nitrite reductase from Alcaligenes xylosoxidans provide insight into the enzyme mechanism

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Click Chemistry with an Active Site Variant of Azurin

Conformation of pseudoazurin in the 152 kDa electron transfer complex with nitrite reductase determined by paramagnetic NMR.

Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

Developmental transition of Plasmodium sporozoites into liver-stage forms is regulated by the RNA binding protein Pumilio 2.

Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits

Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans.

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Illuminating the host - how RNAi screens shed light on host-pathogen interactions

Imidazoquines as antimalarial and antipneumocystis agents

In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

Infection by Plasmodium changes shape and stiffness of hepatic cells

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Inhibition of Plasmodium Liver Infection by Ivermectin

Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins

Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections

Interactions of the malaria parasite and its mammalian host

Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Long-Range-Distance NMR Effects in a Protein Labeled with a Lanthanide–DOTA Chelate

Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.

Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp ⬇️

Met144Ala mutation of the copper-containing nitrite reductase from Alcaligenes xylosoxidans reverses the intramolecular electron transfer

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity

Novel Harmicines with Improved Potency against Plasmodium

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities

Novel potent metallocenes against liver stage malaria

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility.

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells

Platinum(ii)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents

Primaquine homodimers as potential antiplasmodial and anticancer agents

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Purification, Characterization, and Preliminary Crystallographic Study of Copper-Containing Nitrous Oxide Reductase fromPseudomonas nautica617†

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Repurposing Drugs to Fight Hepatic Malaria Parasites

Research funding after COVID-19

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Spiro-Lactams as Novel Antimicrobial Agents

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria