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List of works by Oleg Melnyk

A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide-Protein Conjugates

scientific article

A cysteine selenosulfide redox switch for protein chemical synthesis

scientific article published on 22 May 2020

A one-pot three-segment ligation strategy for protein chemical synthesis

scientific article

A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins

scientific article published on 30 May 2017

A statistical view of protein chemical synthesis using NCL and extended methodologies.

scientific article published on 24 May 2017

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides

scientific article published in Nature Communications

Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates.

scientific article published on 11 January 2016

Access to cyclic or branched peptides using bis(2-sulfanylethyl)amido side-chain derivatives of Asp and Glu

scientific article published on 26 April 2012

Access to large cyclic peptides by a one-pot two-peptide segment ligation/cyclization process

scientific article published on 15 December 2014

Affinity surface-assisted laser desorption/ionization mass spectrometry for peptide enrichment

scientific article

Alpha-oxo semicarbazone peptide or oligodeoxynucleotide microarrays

scientific article published in March 2003

Anchorage of synthetic peptides onto liposomes via hydrazone and alpha-oxo hydrazone bonds. preliminary functional investigations

scientific article

Assembly/disassembly of drug conjugates using imide ligation

scientific article published on September 2010

Biomolecule and Nanoparticle Transfer on Patterned and Heterogeneously Wetted Superhydrophobic Silicon Nanowire Surfaces

scientific article published on 06 February 2008

Bis(2-sulfanylethyl)amido peptides enable native chemical ligation at proline and minimize deletion side-product formation

scientific article published on 11 October 2013

Bis(2-sulfanylethyl)amino native peptide ligation

scientific article published on 21 October 2010

Carbohydrate microarrays in 96-well polystyrene microtiter plates

scientific article published on 01 January 2012

Carbon nanowalls: a new versatile graphene based interface for the laser desorption/ionization-mass spectrometry detection of small compounds in real samples.

scientific article published on 4 July 2017

Catalysis of Hydrazone and Oxime Peptide Ligation by Arginine

scientific article published on 26 October 2020

Catalysis of Thiol-Thioester Exchange by Water-Soluble Alkyldiselenols Applied to the Synthesis of Peptide Thioesters and SEA-Mediated Ligation

scientific article published on 02 October 2018

Characterization of nanogap chemical reactivity using peptide-capped gold nanoparticles and electrical detection

scientific article published on 19 March 2008

Characterization of peptide attachment on silicon nanowires by X-ray photoelectron spectroscopy and mass spectrometry

scientific article

Chemical Protein Synthesis in Medicinal Chemistry

scientific article published on 25 November 2020

Chemical micropatterning of polycarbonate for site-specific peptide immobilization and biomolecular interactions

scientific article

Chemistry-based protein modification strategy for endocytic pathway analysis

scientific article published on 25 March 2010

Chemoselective acylation of fully deprotected hydrazino acetyl peptides. Application to the synthesis of lipopetides

scientific article

Chips from chips: application to the study of antibody responses to methylated proteins

scientific article

Combined thioether/hydrazone chemoselective ligation reactions for the synthesis of glycocluster-antigen peptide conjugates.

scientific article

Comment on "N-terminal Protein Tail Acts as Aggregation Protective Entropic Bristles: The SUMO Case"

scientific article published on 23 July 2020

Covalent linking of peptides onto oxygen-terminated boron-doped diamond surfaces

Current based antibodies detection from human serum enhanced by secondary antibodies labelled with gold nanoparticles immobilized in a nanogap

scientific article published on 9 November 2007

Decoration of silicon nanostructures with copper particles for simultaneous selective capture and mass spectrometry detection of His-tagged model peptide

scientific article

Detecting the chemoselective ligation of peptides to silicon with the use of cobalt-carbonyl labels

scientific article published on 01 August 2006

Determination of glyoxylyl-peptide concentration using oxime chemistry and RP-HPLC analysis

scientific article published on 01 November 2006

Diamond nanowires for highly sensitive matrix-free mass spectrometry analysis of small molecules

scientific article

Direct characterization of native chemical ligation of peptides on silicon nanowires

scientific article published on 06 September 2012

Electrical detection of human immunoglobulins G from human serum using a microbiosensor

scientific article published on 30 March 2007

Exploration of an imide capture/N,N-acyl shift sequence for asparagine native peptide bond formation

scientific article published on 24 March 2013

Fast and facile preparation of nanostructured silicon surfaces for laser desorption/ionization mass spectrometry of small compounds

scientific article published on 14 September 2018

Fluidics of a nanogap

scientific article published on 01 November 2006

Fmoc solid-phase synthesis of peptide thioesters using an intramolecularn,S-acyl shift

scientific article published in June 2005

From protein total synthesis to peptide transamidation and metathesis: playing with the reversibility of N,S-acyl or N,Se-acyl migration reactions.

scientific article

Grafting of synthetic mannose receptor-ligands onto onion vectors for human dendritic cells targeting

scientific article published in October 2002

High sensitive matrix-free mass spectrometry analysis of peptides using silicon nanowires-based digital microfluidic device

scientific article

Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors.

scientific article published on 5 June 2018

Imaging of protein layers with an optical microscope for the characterization of peptide microarrays

scientific article

In situ ligation between peptides and silica nanoparticles for making peptide microarrays on polycarbonate

scientific article published in March 2009

Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells.

scientific article published on 18 January 2012

Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH.

scientific article published on 10 June 2016

Kinetically Controlled Chemoselective Cyclization Simplifies the Access to Cyclic and Branched Peptides

scientific article published on 11 July 2016

Matrix-free laser desorption/ionization mass spectrometry on silicon nanowire arrays prepared by chemical etching of crystalline silicon

scientific article

MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples

scientific article published on 27 April 2017

NMR-based detection of acetylation sites in peptides

scientific article published on August 2010

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

scientific article published on 03 May 2019

Native Chemical Ligation at Serine Revisited

scientific article published on 13 November 2018

Natural T Cell Epitope Containing Methyl Lysines on Mycobacterial Heparin-Binding Hemagglutinin

scientific article published on 02 March 2020

Novel hyperbranched glycomimetics recognized by the human mannose receptor: quinic or shikimic acid derivatives as mannose bioisosteres

scientific article

One-Pot Synthesis of Antigen-Bearing, Lysine-Based Cluster Mannosides Using Two Orthogonal Chemoselective Ligation Reactions This work was financially supported by the ANRS and the Fondation pour la Recherche Médicale (Sidaction grant to CG). We are

scientific article published on 01 March 2000

One-pot chemical synthesis of small ubiquitin-like modifier protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates

scientific article published on 15 January 2015

Parallel synthesis of a lipopeptide library by hydrazone-based chemical ligation

scientific article

Peptide arrays for highly sensitive and specific antibody-binding fluorescence assays

scientific article published on 01 July 2002

Peptide immobilization on amine-terminated boron-doped diamond surfaces

scientific article published on 17 March 2007

Peptide microarrays on bisphenol A polycarbonate

scientific article published in January 2009

Peptide-protein microarrays for the simultaneous detection of pathogen infections

scientific article published in March 2004

Photochemical immobilization of proteins and peptides on benzophenone-terminated boron-doped diamond surfaces

scientific article published in January 2010

Polypeptide semicarbazide glass slide microarrays: characterization and comparison with amine slides in serodetection studies

scientific article published in March 2004

Polysaccharide Microarrays: Application to the Identification of Heparan Sulphate Mimetics ⬇️

scientific article published on January 1, 2012

Polysaccharide microarrays for polysaccharide-platelet-derived-growth-factor interaction studies

scientific article published in May 2006

RYH: a minimal peptidic sequence obtained from beta-chain hemoglobin exhibiting an antimicrobial activity

scientific article published on 27 May 2011

Reactivity of Lys(NH2)-containing peptides toward endopeptidases

scientific article

Se-(9-Fluorenylmethyl) selenoesters; preparation, reactivity, and use as convenient synthons for selenoacids

scientific article published on 01 July 2013

Selective cleavage of an azaGly peptide bond by copper(II). Long-range effect of histidine residue

scientific article published in March 2010

Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds

scientific article published on 02 July 2015

Selenopeptide transamidation and metathesis.

scientific article published on 14 July 2014

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.

scientific article published on 29 January 2015

Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides

scientific article published in February 2005

Sequential native peptide ligation strategies for total chemical protein synthesis.

scientific article

Silver-catalyzed azaGly ligation. Application to the synthesis of azapeptides and of lipid-peptide conjugates.

scientific article

Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation

scientific article published in March 2003

Solid phase protein chemical synthesis

scientific article published on January 2015

Solid-phase enolate chemistry investigated using HR-MAS NMR spectroscopy

scientific article published in January 2002

Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group

scientific article published in September 2003

Structural diversity of human class II histocompatibility molecules induced by peptide ligands

scientific article published on 01 September 2000

Surface-assisted laser desorption-ionization mass spectrometry on titanium dioxide (TiO2) nanotube layers

scientific article

Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge

scientific article published in October 2002

Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-zeta pseudosubstrate lipopeptides

scientific article

Synthesis of Unprotected Linear or Cyclic O-Acyl Isopeptides in Water Using Bis(2-sulfanylethyl)amido Peptide Ligation

scientific article published on 15 June 2015

Synthesis of glyoxylyl peptides using an Fmoc-protected alpha,alpha'-diaminoacetic acid derivative.

scientific article

Synthesis of hydrazinopeptides using solid-phase N-electrophilic amination: extension to the Fmoc/tert-butyl strategy and chemistry of the N-N bond in strong acid media

scientific article published on 01 October 1999

Synthesis of peptide alkylthioesters using the intramolecular N,S-acyl shift properties of bis(2-sulfanylethyl)amido peptides

scientific article published on 21 March 2011

Synthesis of peptide thioacids at neutral pH using bis(2-sulfanylethyl)amido peptide precursors

scientific article published on 27 September 2013

Synthesis of peptide-protein conjugates using N-succinimidyl carbamate chemistry

scientific article published in February 2010

Synthesis of thiazolidine thioester peptides and acceleration of native chemical ligation

scientific article published on 24 February 2011

Tartric acid-based linker for the solid-phase synthesis of C-terminal peptide alpha-oxo aldehydes

scientific article published in June 2001

The Role of the Conserved SUMO-2/3 Cysteine Residue on Domain Structure Investigated Using Protein Chemical Synthesis

scientific article published on 18 September 2019

The collagen assisted self-assembly of silicon nanowires

scientific article

The deprotection of Lys(Mtt) revisited

scientific article published on 01 June 2000

Thiocarbamate-linked peptides by chemoselective peptide ligation

scientific article published in December 2008

Three-component synthesis of neoglycopeptides using a Cu(II)-triggered aminolysis of peptide hydrazide resin and an azide-alkyne cycloaddition sequence

scientific article published on 18 July 2011

Ti-Cp functionalization by deposition of organic/inorganic silica nanoparticles

scientific article published on 7 August 2007

Tidbits for the synthesis of bis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters.

scientific article

Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations

scientific article published on 08 November 2019

Total synthesis of biotinylated N domain of human hepatocyte growth factor.

scientific article published on 14 March 2013

Towards thrombosis-targeted zeolitenanoparticles for laser-polarized129Xe MRI

scholarly article by Frédéric Lerouge et al published 2009 in Journal of Materials Chemistry

α-Oxo aldehyde or glyoxylyl group chemistry in peptide bioconjugation.

scientific article published on 11 April 2013

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