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List of works by Michael Ploug

68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers

scientific article

A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

scientific article

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

scientific article published on 13 June 2018

A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

scientific article

A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor

scientific article published on 2 December 2006

A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

scientific article published on 17 March 2006

A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria

scientific article published on September 1992

ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain

scientific article published on 23 April 2020

Administration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in mice

scientific article

Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma

scientific article

An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.

scientific article published on 5 August 2016

An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum.

scientific article published in November 2017

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

scientific article published on 5 April 2017

C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes

scientific article published on 12 May 2016

Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure.

scientific article

Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor

scientific article published on August 1991

Cell-surface acceleration of urokinase-catalyzed receptor cleavage

scientific article published on 01 January 1997

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol ⬇️

scientific article published on January 25, 1991

Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites.

scientific article published in April 2004

Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

scientific article published on 03 May 2006

Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report

scientific article published on 11 August 2020

Chylomicronemia from GPIHBP1 autoantibodies

scientific article published on 18 September 2020

Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.

scientific article

Crystal Structure of the Urokinase Receptor in a Ligand-Free Form ⬇️

scientific article published on January 21, 2012

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

scientific article

Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit

scientific article published on 15 May 2019

Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C

scientific article published on August 1989

Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

scientific article published on 20 March 2019

Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry

scientific article published in November 2004

Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer

scientific article published on 18 February 2020

Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

scientific article published on 23 December 2013

Evolution and Medical Significance of LU Domain-Containing Proteins

scientific article published on 5 June 2019

Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor.

scientific article published on 27 July 2017

Expression of C4.4A in an In Vitro Human Tissue-Engineered Skin Model

scientific article published on 7 September 2017

Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma

scientific article

Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis

scientific article

First-in-human uPAR PET: Imaging of Cancer Aggressiveness

scientific article

GPIHBP1 and Plasma Triglyceride Metabolism

scientific article published on 14 May 2016

GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.

scientific article published on 13 June 2017

GPIHBP1 autoantibody syndrome during interferon β1a treatment

scientific article published on 24 October 2018

GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding.

scientific article published on 11 November 2014

Glycosylation Profile of a Recombinant Urokinase-type Plasminogen Activator Receptor Expressed in Chinese Hamster Ovary Cells ⬇️

scientific article published on May 29, 1998

Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis

scientific article published on 09 July 2020

Hemolytic plate assay for quantification of active human complement component C3 using methylamine-treated plasma as complement source

scientific article published on 01 May 1985

Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda

scientific journal article

Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.

scientific article

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

scientific article published on 04 October 2012

Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator

scientific article published on April 1992

Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly [...]

scientific article

Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET.

scientific article

Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies

scientific article

In situ alkylation of cysteine residues in a hydrophobic membrane protein immobilized on polyvinylidene difluoride membranes by electroblotting prior to microsequence and amino acid analysis

scientific article published on 01 March 1992

Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements.

scientific article published in March 2009

Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor

scientific article published on 01 August 1994

Lipoprotein lipase is active as a monomer

scientific article published on 08 March 2019

Localization and functional significance of a polymorphic determinant in the third component of human complement.

scientific article published in October 1987

Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma

scientific article published on 01 February 2013

Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region

scientific article

Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography

scientific article

Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.

scientific article published on 24 October 2011

Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries

scientific article published on 3 November 2016

Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.

scientific article published on 15 November 2016

Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain

scientific article

Murine monoclonal antibodies against murine uPA receptor produced in gene-deficient mice: inhibitory effects on receptor-mediated uPA activity in vitro and in vivo

scientific article published in June 2007

NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes

Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice

scientific article (publication date: 15 September 2010)

New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

scientific article published on 26 June 2012

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity

scientific article published on 27 January 2019

One-step affinity purification of recombinant urokinase-type plasminogen activator receptor using a synthetic peptide developed by combinatorial chemistry

scientific article published on 30 August 2006

Peptide Disc Mediated Control of Membrane Protein Orientation in Supported Lipid Bilayers for Surface-Sensitive Investigations

scientific article published on 10 December 2019

Peptide-Based Optical uPAR Imaging for Surgery: In Vivo Testing of ICG-Glu-Glu-AE105

scientific article published in February 2016

Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation

article

Plasminogen activation and cancer

scientific article published on 01 April 2005

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

scientific article

Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice

scientific article published on 01 January 2000

Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

scientific article

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

scientific article published on 13 March 2008

Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

scientific article

Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay

scientific article published on 01 January 1994

Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

scientific article published on January 2012

Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes.

scientific article

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

scientific article

Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris

scientific article

Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor

scientific article published on 02 September 2004

Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody

scientific article published on 17 May 2009

Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation

scientific article

Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor

scientific article

Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator

scientific article published on September 1992

Structure and ligand interactions of the urokinase receptor (uPAR).

scientific article published in May 2008

Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis

scientific article published on 17 December 2018

Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR.

scientific article published on January 1997

Structure-Driven Design of Radionuclide Tracers for Non-Invasive Imaging of uPAR and Targeted Radiotherapy. The Tale of a Synthetic Peptide Antagonist ⬇️

scientific article published on June 24, 2013

Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor

scientific article (publication date: 2003)

Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

scientific article published on August 1994

Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism

scientific article

The PCNA interaction motifs revisited: thinking outside the PIP-box

scientific article published on 27 May 2019

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

scientific article published on 3 January 2016

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

scientific article published on 8 December 2016

The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

scientific article published on 01 December 1997

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator ⬇️

scientific article published on April 25, 1991

The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling

scientific article published on 01 February 2001

The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

scientific article published on 01 February 1994

The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria

scientific article published on 01 March 1992

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

scientific article published on 20 July 2020

The urokinase receptor and regulation of cell surface plasminogen activation.

scientific article published on December 1990

The urokinase receptor as a potential target in cancer therapy.

scientific article published in January 2004

The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia.

scientific article published on 29 July 2013

Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma

scientific article published on July 2016

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.

scientific article published on 06 March 2014

Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer

scientific article published on 13 August 2007

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

scientific article published on 07 February 2020

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

scientific article published on September 1992

Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer

scientific article published on 25 March 2015

Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains.

scientific article

uPAR targeted radionuclide therapy with (177)Lu-DOTA-AE105 inhibits dissemination of metastatic prostate cancer

scientific article

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