List of works - Matthew Fuchter

500-fold amplification of small molecule circularly polarized luminescence through circularly polarized FRET

scientific article published on 08 October 2020

500‐Fold Amplification of Small Molecule Circularly Polarised Luminescence through Circularly Polarised FRET

scientific article published on 3 December 2020

A combinatorial approach to improving the performance of azoarene photoswitches

scientific article published on 14 November 2019

A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule

scientific article published on 9 January 2018

A high throughput screen for next-generation leads targeting malaria parasite transmission

scientific article published in Nature Communications

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

scientific article

A scalable and expedient route to 1-aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy.

scientific article published on 21 March 2013

A ‘push–pull’ tropylium-fused aminoporphyrazine

An unusual oxidative rearrangement of [7]-helicene

Arylazopyrazoles for Long-Term Thermal Energy Storage and Optically-Triggered Heat Release below 0 °C

scientific article published on 22 April 2020

Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives

scientific article published on 14 August 2014

Best practices in the measurement of circularly polarised photodetectors

Calcium-mediated stereoselective reduction of α,β-epoxy ketones

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

scientific article published on March 2013

Chemical Z − E Isomer Switching of Arylazopyrazoles Using Acid

scientific article published on 24 April 2019

Chiroptical studies on brevianamide B: vibrational and electronic circular dichroism confronted

scientific article published on 17 March 2015

Circularly Polarized Phosphorescent Electroluminescence with a High Dissymmetry Factor from PHOLEDs Based on a Platinahelicene

scientific article published on 19 July 2016

Circularly polarized light detection by a chiral organic semiconductor transistor

article

Clean and efficient synthesis of O-silylcarbamates and ureas in supercritical carbon dioxide

scientific article published on 2 April 2008

Computational Screening of Organic Semiconductors: Exploring Side-Group Functionalisation and Assembly to Optimise Charge Transport in Chiral Molecules

scientific article published on 11 June 2020

Computational Screening of Organic Semiconductors: Exploring Side-Group Functionalisation and Assembly to Optimise Charge Transport in Chiral Molecules

article published in 2020

Correction to "Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives

scientific article published on 16 August 2016

Correction to Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality

scientific article published on 04 June 2018

Correction: A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule

scientific article published on 01 May 2018

Corrigendum: Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study

scientific article published on 16 January 2018

Current limitations and future opportunities for epigenetic therapies.

scientific article

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets

scientific article

Designing effective 'frustrated Lewis pair' hydrogenation catalysts

scientific article

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

scientific article

Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

scientific article

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

scientific article

Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes

scientific article published on 06 August 2008

Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles.

scientific article published on 3 August 2016

Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid.

scientific article

Disequilibrating azobenzenes by visible-light sensitization under confinement

scientific article published on 21 September 2023

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

scientific article published on 21 August 2015

Dual wavelength asymmetric photochemical synthesis with circularly polarized light

scientific article published on 16 April 2015

Editorial

Effective macrophage delivery using RAFT copolymer derived nanoparticles

Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality.

scientific article

Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions

scientific article published on 01 June 2019

Facile Protocol for Water-Tolerant "Frustrated Lewis Pair"-Catalyzed Hydrogenation

scientific article published on 17 August 2015

Fullerene Desymmetrization as a Means to Achieve Single-Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness

scientific article published on 23 November 2020

Fullerene Dissymmetrization as a Means to Achieve Single Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness

scientific article published on 18 June 2020

Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages

scientific article published on 28 July 2020

Gold(I) mediated rearrangement of [7]-helicene to give a benzo[cd]pyrenium cation embedded in a chiral framework.

scientific article published on 21 November 2013

Highly efficient inverted circularly polarized organic light emitting diodes

scientific article published on 05 August 2020

Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A.

scientific article

Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity

scientific article published on 15 March 2017

Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Supple

scientific article published on 15 March 2017

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

scientific article

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.

scientific article published on 15 March 2018

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.

scientific article published on 11 September 2014

In memoriam Alasdair James Campbell (11 May 1961–27 February 2021)

scientific article

Induction of circularly polarized electroluminescence from an achiral light-emitting polymer via a chiral small-molecule dopant

scientific article published on 2 April 2013

Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.

scientific article published on 26 January 2017

Intense redox-driven chiroptical switching with a 580 mV hysteresis actuated through reversible dimerization of an azoniahelicene

scientific article published on 24 July 2017

Inverting the Handedness of Circularly Polarized Luminescence from Light-Emitting Polymers Using Film Thickness

scientific article published on 26 June 2019

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors.

scientific article published on 2 June 2014

Lanthanide replacement in organic synthesis: Luche-type reduction of α,β-unsaturated ketones in the presence of calcium triflate

Mechanistic and chiroptical studies on the desulfurization of epidithiodioxopiperazines reveal universal retention of configuration at the bridgehead carbon atoms

scientific article

Metal-free hydrogenation catalyzed by an air-stable borane: use of solvent as a frustrated Lewis base

scientific article published on 11 August 2014

Multigram Synthesis of a Water-Soluble Porphyrazine and Derivedseco-Porphyrazine Labeling Agents

scientific article published on 15 November 2007

Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films

scientific article published on 01 December 2020

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation

scientific article

Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds

scientific article published on 29 October 2014

N‐Heterocyclic Carbene Mediated Activation of Tetravalent Silicon Compounds: A Critical Evaluation ⬇️

scientific article published on November 2, 2010

On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites

scientific article published on 05 September 2011

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

scientific article published on 2 February 2011

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

scientific article published on 25 October 2013

On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective

scientific article published on 08 June 2020

One-Pot Formation of Allylic Chlorides from Carbonyl Derivatives

scientific article published on 04 October 2008

Paper No 2.2: Circularly Polarised Organic Light-Emitting Diodes Using Conventional Light-Emitting Polymers and a Chiral Small-Molecule Dopant

article

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

scientific article published on 9 February 2014

Perspectives on natural product epigenetic modulators in chemical biology and medicine.

scientific article published on May 2013

Photoswitchable basicity through the use of azoheteroarenes

scientific article published on 01 March 2016

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

scientific article (publication date: 23 February 2016)

Porphyrazines as Molecular Scaffolds: Flexible Syntheses of Novel Multimetallic Complexes

scientific article published on 01 May 2006

Porphyrazines: Designer Macrocycles by Peripheral Substituent Change

ROM polymerization-capture-release strategy for the chromatography-free synthesis of novel unsymmetrical porphyrazines

scientific article published in April 2005

ROM polymerization-capture-release: application to the synthesis of unsymmetrical porphyrazinedithiols and peripherally metalated derivatives

scientific article published in June 2005

Regiochemical observations on the lithiation of 1,2,4-trichlorobenzene and reaction with DMF and oxamide electrophiles in THF

Ring-opening metathesis polymer sphere-supported seco-porphyrazines: efficient and recyclable photooxygenation catalysts

scientific article published in January 2006

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

scientific article published on 6 April 2010

Serendipitous synthesis of trimetallic porphyrazine triads

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

scientific article

Stoichiometric C-H arylation of tricarbonyl(arene)chromium complexes bearing pyridine directing groups

scientific article

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

scientific article published on 20 September 2019

Synthesis of porphyrazine-octaamine, hexamine and diamine derivatives

Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids

scientific article published on 01 January 2013

Synthetic studies on the reverse antibiotic natural products, the nybomycins

scientific article published on 24 May 2019

TRPswitch - a step function chemo-optogenetic ligand for the vertebrate TRPA1 channel

scientific article published on 23 September 2020

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

scientific article

The Influence of Nitrogen Position on Charge Carrier Mobility in Enantiopure Aza[6]helicene Crystals

The added value of small-molecule chirality in technological applications

The antimalarial screening landscape-looking beyond the asexual blood stage

scientific article published on 12 March 2019

The design and synthesis of novel IBiox N-heterocyclic carbeneligands derived from substituted amino-indanols

scientific article published on 28 November 2011

The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity

scientific article

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

scientific article

The influence of nitrogen position on charge carrier mobility in enantiopure aza[6]helicene crystals

scientific article published on 01 February 2019

The transcriptional repressor REV-ERB as a novel target for disease

scientific article published on 10 July 2020

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes

scientific article published in March 2014

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

scientific article

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

scientific article published on 15 January 2013

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.

scientific article

Tuning Azoheteroarene Photoswitch Performance through Heteroaryl Design

scientific article published on 23 December 2016

Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides

scientific article published on 25 September 2018

Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid

scientific article published on 24 October 2016

Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid

[7]-Helicene: a chiral molecular tweezer for silver(i) salts

scientific article published on 06 June 2012

List of works by Matthew Fuchter

500-fold amplification of small molecule circularly polarized luminescence through circularly polarized FRET

500‐Fold Amplification of Small Molecule Circularly Polarised Luminescence through Circularly Polarised FRET

A combinatorial approach to improving the performance of azoarene photoswitches

A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule

A high throughput screen for next-generation leads targeting malaria parasite transmission

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

A scalable and expedient route to 1-aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy.

A ‘push–pull’ tropylium-fused aminoporphyrazine

An unusual oxidative rearrangement of [7]-helicene

Arylazopyrazoles for Long-Term Thermal Energy Storage and Optically-Triggered Heat Release below 0 °C

Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives

Best practices in the measurement of circularly polarised photodetectors

Calcium-mediated stereoselective reduction of α,β-epoxy ketones

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

Chemical Z − E Isomer Switching of Arylazopyrazoles Using Acid

Chiroptical studies on brevianamide B: vibrational and electronic circular dichroism confronted

Circularly Polarized Phosphorescent Electroluminescence with a High Dissymmetry Factor from PHOLEDs Based on a Platinahelicene

Circularly polarized light detection by a chiral organic semiconductor transistor

Clean and efficient synthesis of O-silylcarbamates and ureas in supercritical carbon dioxide

Computational Screening of Organic Semiconductors: Exploring Side-Group Functionalisation and Assembly to Optimise Charge Transport in Chiral Molecules

Computational Screening of Organic Semiconductors: Exploring Side-Group Functionalisation and Assembly to Optimise Charge Transport in Chiral Molecules

Correction to "Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives

Correction to Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality

Correction: A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule

Corrigendum: Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study

Current limitations and future opportunities for epigenetic therapies.

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets

Designing effective 'frustrated Lewis pair' hydrogenation catalysts

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes

Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles.

Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid.

Disequilibrating azobenzenes by visible-light sensitization under confinement

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

Dual wavelength asymmetric photochemical synthesis with circularly polarized light

Editorial

Effective macrophage delivery using RAFT copolymer derived nanoparticles

Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality.

Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions

Facile Protocol for Water-Tolerant "Frustrated Lewis Pair"-Catalyzed Hydrogenation

Fullerene Desymmetrization as a Means to Achieve Single-Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness

Fullerene Dissymmetrization as a Means to Achieve Single Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness

Fullerene Dissymmetrization as a Means to Achieve Single Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness

Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages

Gold(I) mediated rearrangement of [7]-helicene to give a benzo[cd]pyrenium cation embedded in a chiral framework.

Highly efficient inverted circularly polarized organic light emitting diodes

Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A.

Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity

Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Supple

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.

In memoriam Alasdair James Campbell (11 May 1961–27 February 2021)

Induction of circularly polarized electroluminescence from an achiral light-emitting polymer via a chiral small-molecule dopant

Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.

Intense redox-driven chiroptical switching with a 580 mV hysteresis actuated through reversible dimerization of an azoniahelicene

Inverting the Handedness of Circularly Polarized Luminescence from Light-Emitting Polymers Using Film Thickness

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors.

Lanthanide replacement in organic synthesis: Luche-type reduction of α,β-unsaturated ketones in the presence of calcium triflate

Mechanistic and chiroptical studies on the desulfurization of epidithiodioxopiperazines reveal universal retention of configuration at the bridgehead carbon atoms

Metal-free hydrogenation catalyzed by an air-stable borane: use of solvent as a frustrated Lewis base

Multigram Synthesis of a Water-Soluble Porphyrazine and Derivedseco-Porphyrazine Labeling Agents

Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation

Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds

N‐Heterocyclic Carbene Mediated Activation of Tetravalent Silicon Compounds: A Critical Evaluation ⬇️

On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective

One-Pot Formation of Allylic Chlorides from Carbonyl Derivatives

Paper No 2.2: Circularly Polarised Organic Light-Emitting Diodes Using Conventional Light-Emitting Polymers and a Chiral Small-Molecule Dopant

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

Perspectives on natural product epigenetic modulators in chemical biology and medicine.

Photoswitchable basicity through the use of azoheteroarenes

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

Porphyrazines as Molecular Scaffolds: Flexible Syntheses of Novel Multimetallic Complexes