List of works - Alessandro Corsaro

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

scientific article

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

scientific article published on January 2007

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells

scientific article published on January 2007

Amyloid precursor protein and presenilin involvement in cell signaling.

scientific article published on January 2007

Amyloid precursor protein modulates ERK-1 and -2 signaling

scientific article published on December 2006

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

scientific article published on 01 August 2000

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

scientific article published on 19 February 2019

Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis

scientific article published in February 2003

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

scientific article

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

scientific article published on 18 November 2014

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

scientific article published on 24 May 2016

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

scientific article

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

scientific article published on December 2006

Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals

scientific article published on 28 October 2005

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.

scientific article

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

scientific article published on 25 May 2017

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

scientific article published on 04 October 2007

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

scientific article published on 10 August 2012

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

scientific article published on 26 February 2009

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

scientific article published on 01 November 2007

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

article

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

scientific article

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

scientific article

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment

scientific article published on 2 August 2012

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

scientific article published in July 2002

Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

scientific article published in January 2004

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

scientific article published on 19 November 2010

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

scientific article

In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity

scientific article

In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas

scientific article published on 01 October 2002

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

scientific article

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

scientific article

Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

scientific article published on 19 December 2012

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling

scientific article published on 08 February 2012

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

scientific article published on 7 February 2018

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

scientific article published on December 2003

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

scientific article published on January 2012

SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

scientific article published on December 2006

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

scientific article published on 01 October 1999

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

scientific article published on April 2003

Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways.

scientific article published on 23 September 2004

The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation

scientific article

The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation

scientific article

The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.

scientific article published on December 2004

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

scientific article published on February 2002

List of works by Alessandro Corsaro

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells

Amyloid precursor protein and presenilin involvement in cell signaling.

Amyloid precursor protein modulates ERK-1 and -2 signaling

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity

In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways.

The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation

The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation

The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells