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List of works by Francesco Simone Ruggeri

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

scientific article

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.

scientific article published on 18 May 2016

Amyloid single-cell cytotoxicity assays by nanomotion detection

scientific article published on 21 August 2017

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

scientific article published on 19 June 2019

Atomic force microscopy for single molecule characterisation of protein aggregation

scientific article published on 08 February 2019

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

scientific article published on 13 July 2020

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

scientific article published on 12 September 2019

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

scientific article published on 07 May 2018

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptide

scientific article published on 22 December 2014

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

scientific article published on 10 June 2021

Detecting nanoscale vibrations as signature of life

scientific article

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

scientific article published on 28 June 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

scientific article published in April 2018

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

scientific article published on 06 March 2019

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

scientific article published on 30 August 2018

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

scientific article published on 14 January 2015

Infrared nanospectroscopic mapping of a single metaphase chromosome

scientific article published on 01 October 2019

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

scientific article published on 28 July 2015

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

scientific article published in 2012

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

scientific article published in Nature Communications

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

scientific article published on 30 March 2018

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

scientific article published on 23 March 2017

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

scientific article published on 5 September 2018

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

scientific article published on 3 July 2017

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

scientific article published on 25 August 2017

Nanoscale spatially resolved infrared spectra from single microdroplets ⬇️

scientific article

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

scientific article published on 08 August 2016

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

scientific article published on 25 June 2020

Silk micrococoons for protein stabilisation and molecular encapsulation

scientific article published on 19 July 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

scientific article published on 10 June 2020

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

scientific article published on 26 July 2019

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

scholarly article by Zhaoying Li published in September 2018

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

scientific article published on 10 August 2018

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

scientific article

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

scientific article published on 17 February 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

scientific article published on 10 April 2018

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