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List of works by Diego Luis Medina

A block of autophagy in lysosomal storage disorders

scientific article

A gene network regulating lysosomal biogenesis and function

scientific article

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

scientific article

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.

scientific article published on 12 May 2016

A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data

scientific article

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

scientific article published on April 2016

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

scientific article published on 11 July 2016

Brain Disorders Due to Lysosomal Dysfunction.

scientific article published on 18 April 2016

Cellular and Gene Expression Response to the Combination of Genistein and Kaempferol in the Treatment of Mucopolysaccharidosis Type I

scientific article published on 19 January 2022

Cystic fibrosis: A disorder with defective autophagy

scientific article published on 01 January 2011

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

scientific article published on 15 August 2010

FGF signalling regulates bone growth through autophagy

scientific article published on 23 November 2015

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High-content drug screening for rare diseases

scientific article published on 07 June 2017

Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells

scientific article published on November 1997

Lysosomal calcium regulates autophagy.

scientific article published on June 2015

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

scientific article published on March 2015

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

scientific article

Mechanism of TrkB-mediated hippocampal long-term potentiation

scientific journal article

Methods to Monitor and Manipulate TFEB Activity During Autophagy

scientific article published on 16 December 2016

Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.

scientific article published on December 2005

RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity

scientific article published in January 2002

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.

scientific article

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

scientific article

Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes

scientific article

Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1.

scientific article published in January 1999

TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response

scientific article published on 10 May 2020

TFEB and the CLEAR network

TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry

scientific article published on 13 January 2017

TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

scientific article published on 10 December 2019

TRPML1: The Ca((2+))retaker of the lysosome.

scientific article

The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells

scientific article

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1

scientific article published on 18 January 2019

The phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activation

scientific article

Transcriptional activation of lysosomal exocytosis promotes cellular clearance

scientific article

TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration

scientific journal article

mTOR-dependent phosphorylation controls TFEB nuclear export

scientific article published in Nature Communications

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