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List of works by Frank Claessens

7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model.

scientific article

A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels

scientific article published on 26 February 2010

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

scholarly article

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene

scientific article published on 13 July 2012

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton

scientific article

AR variants: lost in translation to clinical practice?

scientific article published on 01 August 2019

Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS).

scientific article

Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor.

scientific article

Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs

scientific article

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice.

scientific article

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

scientific article published on 01 April 2021

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: Evidence from targeted AR disruption in mouse osteocytes ⬇️

scientific article published on December 1, 2012

Androgen receptor knockout and knock-in mouse models.

scientific article published on 15 October 2008

Androgen-Regulated Transcription in the Epithelium of the Rat Lacrimal Gland ⬇️

scientific article published on January 1, 1998

Androgen-receptor-specific DNA binding to an element in the first exon of the human secretory component gene.

scientific article published on February 2001

Androgenic induction of cystatin-related protein and the C3 component of prostatic binding protein in primary cultures from the rat lacrimal gland

scientific article

Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.

scientific article

Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.

scientific article

Anti-androgenic properties of Compound A, an analog of a non-steroidal plant compound

scientific article published in March 2003

Apparent coactivation due to interference of expression constructs with nuclear receptor expression

scientific article published on 01 October 2000

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scientific article published on 11 June 2018

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scholarly article published in Nature Genetics

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scholarly article published in Nature Genetics

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

scientific article published in Nature Communications

Calcium and vitamin d supplementation in men

scientific article

Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor.

scientific article

Characterization of an androgen response element within the promoter of the epididymis-specific murine glutathione peroxidase 5 gene.

scientific article published on April 1997

Characterization of the human secretory component gene promoter.

scientific article published on February 1997

Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control

scientific article published on 04 October 2002

Clinical Actionability of the Genomic Landscape of Metastatic Castration Resistant Prostate Cancer

scientific article published on 17 November 2020

Comparing the expression profiles of steroid hormone receptors and stromal cell markers in prostate cancer at different Gleason scores

scientific article published in Scientific Reports

Comparing the rules of engagement of androgen and glucocorticoid receptors

scientific article

Comparison of different androgen bioassays in the screening for environmental (anti)androgenic activity.

scientific article published in October 2005

DNA Demethylation-Dependent AR Recruitment and GATA Factors Drive Rhox5 Homeobox Gene Transcription in the Epididymis ⬇️

scientific article published on February 9, 2012

DNA recognition by the androgen receptor: evidence for an alternative DNA-dependent dimerization, and an active role of sequences flanking the response element on transactivation.

scientific article

Detailed functional studies on androgen receptor mild mutations demonstrate their association with male infertility

scientific article

Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses

scientific article published on 01 April 2000

Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains

scientific article published on August 1999

Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements

scientific article published on 18 March 2004

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells

scientific article published on 24 September 2019

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro.

scientific article

Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage

scientific article

Estrogens and Androgens in Skeletal Physiology and Pathophysiology

scientific article

Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells

scientific article

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

scientific article published on 11 June 2018

Fracture risk and zoledronic acid therapy in men with osteoporosis

scientific article published in November 2012

Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women

scientific article published on 10 September 2018

Functional interplay between two response elements with distinct binding characteristics dictates androgen specificity of the mouse sex-limited protein enhancer

scientific article published on 09 July 2002

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1.

scientific article published on 21 March 2016

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

scientific article published in Nature Communications

Healthy birth after testicular extraction of sperm and ICSI from an azoospermic man with mild androgen insensitivity syndrome caused by an androgen receptor partial loss-of-function mutation

scientific article published in October 2012

Identification and Characterization of Androgen Response Elements ⬇️

scientific article published on January 1, 2011

Identification and characterization of MEL-3, a novel AR antagonist that suppresses prostate cancer cell growth

scientific article published on 10 April 2012

Identification of a Functional Androgen-Response Element in the Exon 1-Coding Sequence of the Cystatin-Related Protein Gene crp2 ⬇️

scientific article published on July 1, 1997

Identification of a multihormone responsive enhancer far upstream from the human tissue-type plasminogen activator gene

scientific article published on January 1997

Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor

scientific article published on 6 May 2004

Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes

scientific article published in May 2008

Implications of a polyglutamine tract in the function of the human androgen receptor

scientific article published on 01 June 2003

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS).

scientific article published on 8 September 2011

Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell

scientific article published on 26 November 2007

Inhibition of Cathepsin K for Treatment of Osteoporosis ⬇️

scientific article published on March 1, 2012

Interaction of androgen and glucocorticoid receptor DNA-binding domains with their response elements

scientific article published in January 1993

Interplay between two hormone-independent activation domains in the androgen receptor

scientific article published on 01 January 2006

Intronic androgen response elements of prostatic binding protein genes

scientific article published in March 1993

Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone levels: results from the European Male Ageing Study.

scientific article

Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study.

scientific article

Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate.

scientific article

Molecular biology of the androgen responses

scientific article published on 01 December 2005

Molecular cloning and characterization of multiple isoforms of the snowdrop (Galanthus nivalis L.) lectin.

scientific article

Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation

scientific article

Muscle-bone interactions: From experimental models to the clinic? A critical update

scientific article

Musculoskeletal frailty: a geriatric syndrome at the core of fracture occurrence in older age.

scientific article

NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth. ⬇️

scientific article published on 23 September 2009

Novel insights in the regulation and mechanism of androgen action on bone.

scientific article published in June 2013

Nuclear extracts enhance the interaction of fusion proteins containing the DNA-binding domain of the androgen and glucocorticoid receptor with androgen and glucocorticoid response elements

scientific article published in March 1994

Once-yearly zoledronic acid in older men compared with women with recent hip fracture

scientific article published on 21 October 2011

Osteoporosis in older men: recent advances in pathophysiology and treatment.

scientific article

Primary rat lacrimal cells undergo acinar-like morphogenesis on reconstituted basement membrane and express secretory component under androgen stimulation

scientific article published on 01 February 1998

Proteins interacting with an androgen-responsive unit in the C3(1) gene intron

scientific article published on 01 August 1993

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

scientific article published on 23 September 2019

Regulation of Androgen Receptor-dependent Transcription by Coactivator MED1 Is Mediated through a Newly Discovered Noncanonical Binding Motif ⬇️

scientific article published on November 18, 2011

Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology

scientific article published in 2022

Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men.

scientific article

Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression.

scientific article

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis.

scientific article

Shared heritability and functional enrichment across six solid cancers

scientific article published in Nature Communications

Shared heritability and functional enrichment across six solid cancers

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

scientific article published on 06 September 2021

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

scientific article published on 5 May 2007

Structural basis for nuclear hormone receptor DNA binding.

scientific article

Structural basis of androgen receptor binding to selective androgen response elements.

scholarly article

Structure of the homodimeric androgen receptor ligand-binding domain

scientific article published on 06 February 2017

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction

scientific article

Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity

scientific article published on June 2008

Testosterone and the male skeleton: a dual mode of action

scientific article

Testosterone boosts physical activity in male mice via dopaminergic pathways.

scientific article published on 17 January 2018

The EMPaCT Classifier: A Validated Tool to Predict Postoperative Prostate Cancer-related Death Using Competing-risk Analysis.

scientific article

The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide.

scientific article

The STAT3 inhibitor galiellalactone reduces IL6-mediated AR activity in benign and malignant prostate models

scientific article published on 25 September 2018

The androgen receptor DNA-binding domain determines androgen selectivity of transcriptional response

scientific article published on December 2006

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

scientific article

The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors

scientific article published on 01 August 1996

The discovery of novel human androgen receptor antagonist chemotypes using a combined pharmacophore screening procedure.

scientific article published on 21 February 2013

The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element

scientific article published on 01 July 1999

The hinge region in androgen receptor control.

scientific article published on 02 March 2012

The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation

scientific article published on 01 December 2004

The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor

scientific article published on May 2007

The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth

scientific article

The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity.

scientific article

The role of single nucleotide polymorphisms in predicting prostate cancer risk and therapeutic decision making

scientific article

The rules of DNA recognition by the androgen receptor.

scientific article published on 19 March 2010

The survival impact of neoadjuvant hormonal therapy before radical prostatectomy for treatment of high-risk prostate cancer.

scientific article published on 9 May 2017

Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis

scientific article published on July 2012

Tissue-specific androgen responses in primary cultures of lacrimal epithelial cells studied by adenoviral gene transfer

scientific article published on 01 October 2001

Tracking prostate cancer development at the single-cell level

scientific article published on 10 July 2020

Tumor Volume and Clinical Failure in High-Risk Prostate Cancer Patients Treated With Radical Prostatectomy.

scientific article

Ubiquitous transcription factors NF1 and Sp1 are involved in the androgen activation of the mouse vas deferens protein promoter.

scientific article published on September 1997

Variations in the exome of the LNCaP prostate cancer cell line

scientific article

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

scholarly article

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