List of works - Christine L Le Maitre

A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration

scientific article published in February 2006

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

scientific article published on 08 October 2018

Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs

scientific article published in February 2009

An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

scientific article published on 11 February 2009

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration

scientific article published on 22 March 2019

Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia.

scientific article published on 18 November 2011

Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia

scientific article

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes

scientific article published on 6 November 2013

Cannabinoids: novel therapies for arthritis?

scientific article published on April 2012

Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.

scientific article

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.

scientific article published on 05 August 2008

Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration

scientific article published on 01 October 2008

Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy.

scientific article

Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies

scientific article published on 29 March 2001

Degeneration of the intervertebral disc with new approaches for treating low back pain.

scientific article

Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration

scientific article

Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

scientific article published on December 2013

Do intervertebral discs degenerate before they herniate, or after?

scientific article published in August 2013

Dual colour FISH in paraffin wax embedded bone trephines for identification of numerical and structural chromosomal abnormalities in acute myeloid leukaemia and myelodysplasia

scientific article

Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells

scientific article published on July 2012

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

scientific article published on 20 August 2014

Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells

scientific article published on 15 September 2009

Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc

scientific article published in December 2005

Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines.

scientific article published on 31 December 2015

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

scientific article published on 19 November 2019

Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure

scientific article published on 01 January 2008

Human disc degeneration is associated with increased MMP 7 expression

scientific article published in July 2006

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

scientific article published in 2022

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

scientific article published on 11 June 2020

Improving reproducibility in spine research

scientific article published on 29 September 2020

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration

scientific journal article

Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration

scientific article published on 8 July 2016

Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration

scientific article published on 09 February 2013

Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging

scientific article (publication date: 23 June 2016)

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

scientific article published on 08 April 2008

Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical

scientific article published on 02 August 2018

Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc

scientific article published on 01 September 2004

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease

scientific article published in Scientific Reports

Matrix synthesis and degradation in human intervertebral disc degeneration.

scientific article published on August 2007

Mesenchymal stem cell therapies for intervertebral disc degeneration: Consideration of the degenerate niche

scientific article published on 26 June 2019

Microgel particles containing methacrylic acid: pH-triggered swelling behaviour and potential for biomaterial application

scientific article published on 19 August 2007

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

scientific article

Molecular mechanisms of biological aging in intervertebral discs

scientific article

Nerve growth factor expression and innervation of the painful intervertebral disc

scientific article published on 01 July 2002

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc.

scientific article published on 21 December 2015

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

scientific article published on 28 December 2015

Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines

scientific article

Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes

scientific article published on 4 March 2015

Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

article

Studies of human intervertebral disc cell function in a constrained in vitro tissue culture system

scientific article published in June 2004

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc.

scientific article published on January 2013

The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration

scientific article

The use of auxetic materials in tissue engineering

scientific article published on 26 March 2020

Thermally triggered injectable hydrogel, which induces mesenchymal stem cell differentiation to nucleus pulposus cells: Potential for regeneration of the intervertebral disc

scientific article published on 17 March 2016

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1.

scientific article published in March 2013

Use of l-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering

scientific article published on 01 September 2019

List of works by Christine L Le Maitre

A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs

An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration

Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia.

Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes

Cannabinoids: novel therapies for arthritis?

Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.

Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration

Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy.

Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies

Degeneration of the intervertebral disc with new approaches for treating low back pain.

Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration

Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

Do intervertebral discs degenerate before they herniate, or after?

Dual colour FISH in paraffin wax embedded bone trephines for identification of numerical and structural chromosomal abnormalities in acute myeloid leukaemia and myelodysplasia

Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells

Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc

Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines.

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure

Human disc degeneration is associated with increased MMP 7 expression

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

Improving reproducibility in spine research

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration

Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration

Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration

Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical

Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease

Matrix synthesis and degradation in human intervertebral disc degeneration.

Mesenchymal stem cell therapies for intervertebral disc degeneration: Consideration of the degenerate niche

Microgel particles containing methacrylic acid: pH-triggered swelling behaviour and potential for biomaterial application

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

Molecular mechanisms of biological aging in intervertebral discs

Nerve growth factor expression and innervation of the painful intervertebral disc

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc.

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines

Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes

Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

Studies of human intervertebral disc cell function in a constrained in vitro tissue culture system

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc.

The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration

The use of auxetic materials in tissue engineering

Thermally triggered injectable hydrogel, which induces mesenchymal stem cell differentiation to nucleus pulposus cells: Potential for regeneration of the intervertebral disc

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1.

Use of l-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering