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List of works by Takahiro Kodama

Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet

scientific article published on 2 July 2010

Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver Tumorigenesis.

scientific article published on 2 June 2015

Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway.

scientific article

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq

scientific article published in August 2016

Autophagy impairment in pancreatic acinar cells causes zymogen granule accumulation and pancreatitis

scientific article published on 10 July 2018

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

scientific article

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells

scientific article published on December 2009

Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis.

scientific article published on 10 March 2012

CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma

scientific article published on 13 September 2019

CTGF Mediates Tumor-Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression

scientific article published on 02 July 2018

Carbamazepine promotes liver regeneration and survival in mice

scientific article published on 18 July 2013

Cholesterol Metabolism is Enhanced in the Liver and Brain of Children with Citrin Deficiency.

scientific article published on 5 April 2018

Circulating Cell-Free DNA Profiling Predicts the Therapeutic Outcome in Advanced Hepatocellular Carcinoma Patients Treated with Combination Immunotherapy

scientific article published in 2022

Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without sodium pyruvate treatment.

scientific article published on 24 December 2016

Clinical outcomes of direct-acting antiviral treatments for hepatitis C patients after hepatocellular carcinoma are equivalent to interferon treatment

scientific article published on 17 July 2020

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice

scientific article published on 25 January 2019

Cotreatment with lenvatinib and warfarin potassium caused prothrombin time prolongation

scientific article published on 10 July 2019

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway

scientific article published on 31 May 2018

Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice

scientific article published on 11 April 2011

Exosomal microRNAs derived from colon cancer cells promote tumor progression by suppressing fibroblast TP53 expression

scientific article published on 09 July 2019

Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion

scientific article published on 20 February 2010

Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice

scientific article published on 24 October 2019

Frequency of, and factors associated with, hepatitis B virus reactivation in hepatitis C patients treated with all-oral direct-acting antivirals: Analysis of a Japanese prospective cohort.

scientific article published on 5 June 2017

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

scientific article published on 28 August 2019

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

scientific article published on 22 January 2020

Hepatocellular Carcinoma Due to a Baffle Obstruction After the Mustard Operation: A Case Report

scientific article published on 22 December 2017

Hepatocellular carcinoma occurrence does not differ between interferon-based and interferon-free treatment with liver histological assessment

scientific article published on 08 January 2020

Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma

scientific article published on 01 December 2019

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice

article

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

scientific article published on 15 August 2017

Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response

scientific article published on 06 February 2019

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

scientific article published on 11 July 2011

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

scientific article

Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma

scientific article published on 18 August 2020

Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway.

scientific article

Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

scientific article published on September 2012

Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.

scientific article published on 21 March 2015

Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice

scientific article published on 26 February 2011

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

scientific article published on 05 November 2019

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

scientific article published on October 2009

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

scientific article

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

NS5A-P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection.

scientific article published on 9 February 2018

Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction

scientific article published on 10 October 2012

Predictive factors of anemia during sofosbuvir and ribavirin therapy for genotype 2 chronic hepatitis C patients

scientific article published on 23 May 2019

Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD

scientific article published in 2024

Risk of hepatocellular carcinoma after sustained virologic response in hepatitis C virus patients without advanced liver fibrosis

scientific article published on 24 June 2022

Serum Amino Acid Profiling in Citrin-Deficient Children Exhibiting Normal Liver Function During the Apparently Healthy Period.

scientific article published on 14 April 2018

Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients

scientific article published on 12 July 2019

Synthetic lethal interaction of combined CD26 and Bcl-xL inhibition is a powerful anticancer therapy against hepatocellular carcinoma.

scientific article published on 9 October 2014

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

scientific article published on 28 August 2013

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

scientific article published on October 2010

The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice.

scientific article published on 13 March 2013

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

scientific article

Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension

scientific article published on 19 June 2020

Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice

scientific article

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.

scientific article

Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation.

scientific article published on 24 June 2013

White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice

scientific article published on 22 July 2021

p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.

scientific article published on 12 August 2016

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