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List of works by Roberto J. Botelho

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

scientific article

Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase

scientific article

Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate

scientific article

BioEssays in phosphoinositides: A special collection

scientific article published on 01 February 2014

Changing phosphoinositides "on the fly": how trafficking vesicles avoid an identity crisis.

scientific article

Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis

scientific article

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

scientific article published on 04 December 2019

Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup

scientific article (publication date: April 2003)

Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis

scientific article published on 15 March 2001

Iron overload inhibits late stage autophagic flux leading to insulin resistance

scientific article published on 23 August 2019

Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.

scientific article published on 21 August 2009

Lysophosphatidic acid represses autophagy in prostate carcinoma cells

scientific article published on 07 November 2018

Lysosome Fission: Planning for an Exit

scientific article published on 03 June 2019

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

scientific article published on 16 April 2018

Lysosome remodelling and adaptation during phagocyte activation.

scientific article

PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.

scientific article

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB.

scientific article published on 5 July 2016

Phagocytosis: Hungry, Hungry Cells

scientific article published on January 2017

Phagocytosis: what's on the menu? 1

scientific article published on 23 May 2018

Phagosomal Maturation, Acidification, and Inhibition of Bacterial Growth in Nonphagocytic Cells Transfected with FcγRIIA Receptors

scientific article published in Journal of Biological Chemistry

Phagosome maturation: a few bugs in the system.

scientific article

Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

scientific article published on 27 July 2011

Phosphoinositide Diversity, Distribution, and Effector Function: Stepping Out of the Box.

scientific article

Quantifying Phagocytosis by Immunofluorescence and Microscopy.

scientific article published on January 2017

Quantitative Immunofluorescence to Study Phagosome Maturation

scientific article published in January 2017

Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages ⬇️

scientific article published on September 13, 2012

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation

scientific article published on 6 January 2016

Role of COPI in phagosome maturation

scientific article published in May 2000

Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium

scientific article published on 16 August 2017

The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology.

scientific article

The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.

scientific article

The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase

scientific article

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells.

scientific article

The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation

scientific article published on 22 May 2015

The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic.

scientific article

The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic.

scientific article published on 2 June 2017

The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core

scientific article published on April 2001

Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function

scientific article published on 6 February 2013

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

scientific article

pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels.

scientific article published on 31 October 2017

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