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List of works by Wilhelmus Drinkenburg

Aberrant transients in the EEG of epileptic rats: a spectral analytical approach

scientific article published in October 1993

Absence epilepsy and the level of vigilance in rats of the WAG/Rij strain

scientific article published in January 1991

Anti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model

scientific article published on 24 April 2014

Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

scientific article published on 20 May 2014

Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia.

scientific article

Blockade of the metabotropic glutamate (mGluR2) modulates arousal through vigilance states transitions: evidence from sleep-wake EEG in rodents

scientific article

Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep-wake architecture

scientific article published on 23 October 2007

Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: evidence from MCH1 (-/-) mice

scientific article published on 11 November 2010

Correction for model selection bias using a modified model averaging approach for supervised learning methods applied to EEG experiments

scientific article

Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential

scientific article published on 30 August 2014

Cross-cultural structures of concentric and diametric dualism in Lévi-Strauss' structural anthropology: structures of relation underlying the self and ego relation?

scientific article published in January 2003

Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel

scientific article published in June 2008

Differential effects of midazolam and zolpidem on sleep-wake states and epileptic activity in WAG/Rij rats

scientific article published in August 1995

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

scientific article published on 24 February 2012

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor

scientific article

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

scientific article

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

scientific article published on 20 May 2015

Disorder specificity despite comorbidity: resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder

scientific article

Disruption of glycogen synthase kinase-3-beta activity leads to abnormalities in physiological measures in mice

scientific article published on 8 March 2011

EEG alpha power as an intermediate measure between brain-derived neurotrophic factor Val66Met and depression severity in patients with major depressive disorder.

scientific article published in June 2013

EEG in the FEAB model: measurement of electroencephalographical burst suppression and seizure liability in safety pharmacology

scientific article published on 22 June 2010

Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats

scientific article

Effects of loreclezole on epileptic activity and on EEG and behaviour in rats with absence seizures

scientific article published on October 1992

Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: towards translational challenge models for drug discovery in Alzheimer's disease.

scientific article published on 04 October 2012

Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats

scientific article published on 01 January 1996

Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patients

scientific article published on 29 December 2009

Fronto-temporal alterations within the first 200 ms during an attentional task distinguish major depression, non-clinical participants with depressed mood and healthy controls: A potential biomarker?

scientific article published on 01 February 2009

Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats

scientific article published on July 1, 1992

Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG)

scientific article

How to keep the brain awake? The complex molecular pharmacogenetics of wake promotion.

scientific article published on 4 February 2009

Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia

scientific article published on 12 October 2013

Ictal stimulus processing during spike-wave discharges in genetic epileptic rats

scientific article published in August 2003

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor

scientific article

JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease

scientific article published on 24 September 2014

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery

scientific article published on 13 March 2014

Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture

scientific article

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

scientific article published on 26 December 2014

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

scientific article

Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats

scientific article published on 18 October 2014

Neuromedin U(2) receptor signaling mediates alteration of sleep-wake architecture in rats

scientific article published on 5 February 2011

Neuropeptide-S evoked arousal with electroencephalogram slow-wave compensatory drive in rats

scientific article published on 26 April 2012

Neurophysiological predictors of non-response to rTMS in depression

scientific article

On-Going Frontal Alpha Rhythms Are Dominant in Passive State and Desynchronize in Active State in Adult Gray Mouse Lemurs

scientific article published on 30 November 2015

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.

scientific article published on 13 June 2013

Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.

scientific article published on 30 September 2014

Physiological and hormonal responses to novelty exposure in rats are mainly related to ongoing behavioral activity

scientific article

Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies

scientific article published on 12 October 2006

R278995/CRA0450, a corticotropin-releasing factor (CRF(1)) receptor antagonist modulates REM sleep measures in rats: Implication for therapeutic indication

scientific article

Recognition memory in rats--I. Concepts and classification

scientific article published on February 1998

Recognition memory in rats--II. Neuroanatomical substrates

scientific article published on February 1998

Recognition memory in rats--III. Neurochemical substrates

scientific article published on February 1998

Selective D1 agonism but not D2 antagonism is reflected in cAMP and cGMP levels in rat CSF.

scientific article published on 14 December 2009

Sleep and EEG patterns in the chronic constriction injury model of neuropathic pain

scientific article published in February 2003

Sleep and EEG profile in neonatal hippocampal lesion model of schizophrenia

scientific article

Spike-wave discharges and sleep-wake states in rats with absence epilepsy

scientific article published in September 1991

Strain differences in hippocampal EEG are related to strain differences in behaviour in rats

scientific article published in January 2003

The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats

The effects of QEEG-informed neurofeedback in ADHD: an open-label pilot study

scientific article

The relationship between hippocampal EEG theta activity and locomotor behaviour in freely moving rats: effects of vigabatrin

scientific article published in January 2005

Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.

scientific article

Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men.

scientific article published on 11 December 2015

Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

scientific article published on 21 March 2007

mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats

scientific article

vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol

scientific article published on 8 January 2009

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