List of works by Tetsuya Terasaki

1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier.

scientific article

24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression

scientific article published on 13 November 2006

A carrier-mediated transport system for benzylpenicillin in isolated hepatocytes

scientific article published on January 1985

A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters

scientific article published on 12 March 2007

A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat.

scientific article published in October 2004

A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FV

scientific article published on 8 June 2013

ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline

scientific article published in June 2002

ATP-binding cassette transporter A subfamily 8 is a sinusoidal efflux transporter for cholesterol and taurocholate in mouse and human liver

scientific article published on 4 January 2018

ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier.

scientific article published on 8 December 2007

ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells

scientific article published on 25 May 2006

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

scientific article published in September 2009

Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization

scientific article

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

scientific article

Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells

scientific article published in April 1992

Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST).

scientific article

Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids

scientific article published in February 1990

Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells

scientific article published on 23 January 2017

Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo

scientific article published in September 2001

Age-related change in tissue-to-plasma partition coefficient of cefazolin for noneliminating organs in the rat.

scientific article published in July 1989

Age-related change of cefazolin binding to rat serum proteins and its relation to the molar ratio of free fatty acid to serum albumin

scientific article published on 01 January 1986

All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase.

scientific article published on 12 February 2017

Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment

scientific article published on August 2007

Amyloid beta25-35 impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells

scientific article published on 25 June 2019

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

scientific article published on 17 June 2011

An application of microdialysis to drug tissue distribution study: in vivo evidence for free-ligand hypothesis and tissue binding of beta-lactam antibiotics in interstitial fluids.

scientific article published on February 1992

Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration

scientific article published on 26 February 2017

Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier

scientific article published on 14 July 2010

Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.

scientific article

Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

scientific article

Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells

scientific article published on November 2002

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier

scientific article published on 20 April 2008

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency

scientific article

Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane

scientific article published on 01 February 1987

Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and

scientific article published on 09 August 2011

Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

scientific article

Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system

scientific article published on 18 March 2004

Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys

scientific article published on 19 June 2014

Blood-brain barrier transport of a novel micro 1-specific opioid peptide, H-Tyr-D-Arg-Phe-beta-Ala-OH (TAPA).

scientific article published on March 2003

Blood-brain barrier transport of ebiratide and its uptake by cerebral neuronal cells.

scientific article published on May 1993

Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process.

scientific article published on 7 December 2012

Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier

scientific article

Brain and heart specific alteration of methamphetamine (MAP) distribution in MAP-sensitized rat.

scientific article published in April 2003

Brain insulin impairs amyloid-beta(1-40) clearance from the brain.

scientific article published in October 2004

Brain-to-blood active transport of beta-alanine across the blood-brain barrier

scientific article published on 01 January 1997

Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats

scientific article published on 01 October 2000

Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier

scientific article published on 14 September 2007

Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology

scientific article

CS-25MOLECULAR SUBCLASSIFICATION OF GLIOBLASTOMA BASED ON THE ABSOLUTE QUANTITATIVE PROTEOMICS

Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship

scientific article published on 01 April 1982

Carbenicillin prodrugs: stability kinetics of alpha-phenyl and alpha-indanyl esters in aqueous solution

scientific article published in October 1979

Carrier-mediated transport of H1-antagonist at the blood-brain barrier: a common transport system of H1-antagonists and lipophilic basic drugs.

scientific article published in November 1994

Carrier-mediated transport of H1-antagonist at the blood-brain barrier: mepyramine uptake into bovine brain capillary endothelial cells in primary monolayer cultures

scientific article

Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport

scientific article

Cell density-dependent mitogenic effect and -independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes

scientific article published on 01 February 1997

Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain

scientific article published on 5 December 2017

Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes

scientific article

Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier

scientific article published on 12 August 2010

Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier

scientific article published on January 2001

Characterization of the mechanism of zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT.

scientific article

Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus

scientific article published in April 1996

Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

scientific article published on 03 December 2018

Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions.

scientific article

Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat.

scientific article

Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells.

scientific article

Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats

scientific article published on 01 November 1995

Contributions of degradation and brain-to-blood elimination across the blood-brain barrier to cerebral clearance of human amyloid-β peptide(1-40) in mouse brain

scientific article published on 21 August 2013

Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation

scientific journal article

Correlation of Organic Cation/Carnitine Transporter 1 and Multidrug Resistance-Associated Protein 1 Transport Activities With Protein Expression Levels in Primary Cultured Human Tracheal, Bronchial, and Alveolar Epithelial Cells.

scientific article published in October 2015

Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.

scientific article

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy

scientific article published on 24 January 2013

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

scientific article published on 14 April 2017

Degradation kinetics of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770) and structure-stability relationship among its analogues in aqueous solution

scientific article

Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease

scientific article published on 13 August 2009

Differential binding of testosterone and estradiol to isoforms of sex hormone-binding globulin: selective alteration of estradiol binding in cirrhosis

scientific article published on October 1988

Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats

scientific article published on 7 April 2005

Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo

scientific article published on 6 April 2011

Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis

scientific article published in July 2004

Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters

scientific article published on 14 August 2019

Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.

scientific article published in October 2005

Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers

scientific article

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

scientific article

Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats.

scientific article published on 13 February 2018

Drug Transporter Protein Quantification of Immortalized Human Lung Cell Lines Derived from Tracheobronchial Epithelial Cells (Calu-3 and BEAS2-B), Bronchiolar-Alveolar Cells (NCI-H292 and NCI-H441), and Alveolar Type II-like Cells (A549) by Liquid C

scientific article

Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect

scientific article

Dysfunction of choline transport system through blood-brain barrier in stroke-prone spontaneously hypertensive rats

scientific article published in January 1990

Effect of extracellular water volume on the distribution kinetics of beta-lactam antibiotics as a function of age.

scientific article

Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic rats

scientific article published on 01 May 1991

Effects of arginine-vasopressin fragment 4-9 on rodent cholinergic systems

scientific article published in August 1999

Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor.

scientific article

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

scientific article published on 21 September 2004

Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier

scientific article

Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells

scientific article published on 05 December 2007

Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

scientific article

Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1.

scientific article

Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid

scientific article

Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells

scientific article published on 22 February 2007

Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats

scientific article published on 14 June 2006

Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: a new in vitro blood-nerve barrier (BNB) model.

scientific article

Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function

scientific article

Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats

scientific article published on January 2001

Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2).

scientific article published on June 2003

Evidence for creatine biosynthesis in Müller glia

scientific article

Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells

scientific article published on January 2007

Experimental evidence of characteristic tissue distribution of adriamycin. Tissue DNA concentration as a determinant

scientific article published on 01 September 1982

Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant

scientific article

Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).

scientific article published in September 2003

Expression of ABC-type transport proteins in human platelets

scientific article published in June 2010

Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier

scientific article

Expression of the Na+ dependent uridine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes.

scientific article published in May 1993

Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour

scientific article published on 29 December 2008

From somatostatin to sandostatin: pharmacodynamics and pharmacokinetics

scientific article published on September 1, 1992

Function and regulation of taurine transport at the inner blood-retinal barrier

scientific article published on 28 November 2006

Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers

scientific journal article

Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier

scientific article published on 22 August 2006

Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes

scientific article

Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)

scientific journal article

GSK-3β/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy

scientific article published on 27 April 2011

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels.

scientific article published on 8 March 2018

Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

scientific article published on 6 April 2018

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

scientific article published on 15 January 2017

Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases

scientific article published on 19 December 2014

Global and Targeted Proteomics of Prostate Cancer Cell Secretome: Combination of 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry and In Silico Selection Selected Reaction Monitoring Analysis

scientific article published on 21 September 2016

Hepatic uptake of octreotide, a long-acting somatostatin analogue, via a bile acid transport system

scientific article published on 01 January 1995

High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human

scientific article

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

scientific article published on 23 February 2009

Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro

scientific article published on 7 September 2006

Identification of Blood-Brain Barrier-Permeable Proteins Derived from a Peripheral Organ: In Vivo and in Vitro Evidence of Blood-to-Brain Transport of Creatine Kinase

scientific article published on 12 December 2018

Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics

scientific article

Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

scientific article

Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics.

scientific article published on 29 November 2012

In vitro models for the blood-brain barrier.

scientific article published on April 2005

In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

scientific article

In vivo and in vitro evidence for a common carrier mediated transport of choline and basic drugs through the blood-brain barrier

scientific article

In vivo delivery of small interfering RNA targeting brain capillary endothelial cells

scientific article published on 9 December 2005

In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier

scientific article published in March 2002

In vivo transport of a dynorphin-like analgesic peptide, E-2078, through the blood-brain barrier: an application of brain microdialysis

scientific article published on July 1, 1991

In-vitro evidence for carrier-mediated uptake of acidic drugs by isolated bovine brain capillaries

scientific article

In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier

scientific article published on 01 March 2000

In-vivo blood-brain barrier transport of a novel adrenocorticotropic hormone analogue, ebiratide, demonstrated by brain microdialysis and capillary depletion methods

scientific article published on July 1, 1992

Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells

scientific article published on September 2005

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

scientific article

Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation

scientific article published on 01 November 2006

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

scientific article published on 27 September 2017

Inner blood-retinal barrier mediates l-isomer-predominant transport of serine

scientific article published on 17 May 2011

Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes

scientific article

Interaction of doxorubicin with nuclei isolated from rat liver and kidney

scientific article published on 01 April 1984

Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan

scientific article published on October 2002

Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits

scientific article published on 01 November 1993

Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

scientific article published on 28 April 2008

Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis

scientific article published on 08 July 2018

Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells

scientific article published in January 2014

Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E(2) across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins

scientific article published in March 2010

Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier

scientific article published in February 2006

Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone

scientific article

Is P-glycoprotein involved in amyloid-β elimination across the blood-brain barrier in Alzheimer's disease?

scientific article published in October 2010

Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake

scientific article published on 01 January 1986

Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation

scientific article published in July 1996

L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier

scientific article published on July 2005

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

scientific article published on 23 January 2017

Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway

scientific article published on 26 March 2010

Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

scientific article

Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus

scientific article published on 05 March 2018

Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells

scientific article published on October 2002

Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.

scientific article

MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina

scientific article published on December 2001

MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells.

scientific article published on 14 February 2017

Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells.

scientific article

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver

scientific article published on 21 June 2006

Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney

scientific article published in May 2002

Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans.

scientific article

Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice

scientific article published in August 2006

Molecular mechanisms of drug influx and efflux transport at the blood-brain barrier

scientific article published on July 2003

Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.

scientific article published on 6 September 2011

Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier

scientific article published on 4 February 2004

Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter

scientific article

Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate.

scientific article published in August 1991

Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier

scientific article published on 01 November 1995

New approaches to in vitro models of blood-brain barrier drug transport.

scientific article published on October 2003

Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-beta1 and beta-glycerophosphate.

scientific article

Nuclear binding as a determinant of tissue distribution of adriamycin, daunomycin, adriamycinol, daunorubicinol and actinomycin D

scientific article published on 01 May 1984

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

scientific article published on 22 January 2016

Organic Anion-Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats

scientific article published on 22 April 2019

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

scientific article published in August 2004

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

scientific article published on January 1, 1992

PKC/MAPK signaling suppression by retinal pericyte conditioned medium prevents retinal endothelial cell proliferation

scientific article

Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles

scientific article published on 01 September 1991

Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors

scientific article published on January 2011

Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells

scientific article

Perspectives on a pharmacokinetics legend: C versus T (contributions over time).

scientific article

Pharmacokinetic study on the mechanism of tissue distribution of doxorubicin: interorgan and interspecies variation of tissue-to-plasma partition coefficients in rats, rabbits, and guinea pigs.

scientific article published in October 1984

Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers.

scientific article

Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models

scientific article published on 24 July 2014

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

scientific article published on 01 November 1983

Platelet-derived growth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype

scientific article

Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs

scientific article published on November 2002

Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)

scientific article published on August 2009

Professor Akira Tsuji: scientist, educator, and leader

scientific article published on 31 May 2011

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

scientific article

Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates.

scientific article

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

scientific article published on 27 June 2016

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

scientific article published on 20 February 2015

Quantitative Targeted Absolute Proteomics (QTAP)-based Pharmacoproteomics: The Importance of International Collaboration.

scientific article

Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney

scientific journal article

Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.

scientific article published on 8 June 2016

Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment

scientific article published on 17 August 2015

Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset

scientific article published on 6 May 2013

Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

scientific article published on 01 June 2008

Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.

scientific article published on 13 May 2013

Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

scientific article published on 19 January 2011

Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks.

scientific article published on 5 December 2014

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

scientific article published on 25 February 2011

Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen

scientific article

Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.

scientific article published on 10 May 2011

Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated α-fibrinogen in plasma for pancreatic cancer diagnosis

scientific article published on 18 January 2013

Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.

scientific article published on 04 April 2014

Rat brain pericyte cell lines expressing beta2-adrenergic receptor, angiotensin II receptor type 1A, klotho, and CXCR4 mRNAs despite having endothelial cell markers

scientific article published in October 2003

Receptor-mediated endocytosis of A14-125I-insulin by the nonfiltering perfused rat kidney

scientific article

Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver

scientific article published on September 1991

Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells

scientific article published on November 2003

Recurrent anaplastic meningioma treated by sunitinib based on results from quantitative proteomics

scientific article published on 01 February 2012

Reduction of L-type amino acid transporter 1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease

scientific article published on January 2010

Regulation of extracellular-superoxide dismutase in rat retina pericytes

scientific article published on January 2010

Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity

scientific article published on December 2002

Relationship between lipophilicity and binding affinity with human serum albumin for penicillin and cephem antibiotics.

scientific article published in March 1992

Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry wi

scientific article published on 04 May 2011

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

scientific article

Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain.

scientific article published on March 2005

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

scientific article published in October 2002

Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine

scientific article published on 30 December 2008

Saturable uptake of cefixime, a new oral cephalosporin without an alpha-amino group, by the rat intestine

scientific article published on 01 April 1987

Scrambled Internal Standard Method for High-Throughput Protein Quantification by Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry

scientific article

Selective analysis of mutual displacement effects at the primary binding sites of phenoxymethylpenicillin and cephalothin bindings to human serum albumin.

scientific article published in March 1992

Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA.

scientific article

Serum protein binding of lomefloxacin, a new antimicrobial agent, and its related quinolones

scientific article published on 01 June 1989

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

scientific article published on 12 October 2011

Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

scientific article published on 16 June 2010

Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane.

scientific article published in May 1990

Specific binding of beta-endorphin to the isolated renal basolateral membranes in vitro.

scientific article

Spleen lymphocyte kinetics in mice under normal and inflammatory conditions: an application of the transgenic mouse expressing beta-galactosidase (ROSA 26)

scientific article published on 01 October 2002

Stereospecificity of triiodothyronine transport into brain, liver, and salivary gland: role of carrier- and plasma protein-mediated transport

scientific article

Studies on the Mechanism of Drug Distribution in Tissues ⬇️

scientific article published on 01 December 1992

Targeted drug delivery to the brain; (blood-brain barrier, efflux, endothelium, biological transport).

scientific article published in January 2000

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

scientific article

The blood-brain barrier efflux transporters as a detoxifying system for the brain

scientific article published on 01 April 1999

The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport

scientific article published on 30 December 2016

The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters

scientific article published on 17 August 2009

The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process

scientific article

The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier

scientific article published in November 2003

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

scientific article published on 21 October 2008

Theoretical consideration of drug distribution kinetics in a noneliminating organ: comparison between a "homogeneous (well-stirred)" model and "nonhomogeneous (tube)" model

article published in 1985

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

scientific article published in October 2009

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

scientific article

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

scientific article published on 8 July 2011

Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system

scientific article published on 01 August 1991

Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Evidence for a carrier-mediated transport system

scientific article

Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma

scientific article published in January 1993

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

scientific article published on May 2015

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS.

scientific article published on 7 April 2014

Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat.

scientific article published on 8 June 2005

Vitamin C transport in oxidized form across the rat blood-retinal barrier

scientific article published on April 2004

[Multi-disciplinary research approaches on the brain barrier transport system, a dynamic interface]

scientific article published on 01 February 2013

mRNA expression and amino acid transport characteristics of cultured human brain microvascular endothelial cells (hBME).

scientific article published in January 2002

mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.

scientific article published on 30 October 2007

mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells

scientific article published in September 2004

pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis

scientific article

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