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List of works by Patrick M. Dougherty

A cytokine-based neuroimmunologic mechanism of cancer-related symptoms

scientific article published in January 2004

A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha

scientific article

A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli

scientific article published on 01 October 1994

A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy

scientific article

Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha

scientific article published on 25 July 2011

Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy

scientific article published on 17 June 2014

Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia

scientific article published on 19 December 2005

An overview of animal models of pain: disease models and outcome measures

scientific article published on 12 September 2013

Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms

scientific article

Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

scientific article

Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy

scientific article

Behavioral and electrophysiological studies in rats with cisplatin-induced chemoneuropathy

scientific article published on 15 July 2008

Central sensitization and cutaneous hyperalgesia

Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy

scientific article

Changes in sensory processing in the spinal dorsal horn accompany vincristine-induced hyperalgesia and allodynia

scientific article published in May 2003

Characterization of baroreceptor-related neurons in the monkey insular cortex

scientific article published in June 1998

Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons

article

Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505).

scientific article

Cyclooxygenase inhibitors and thalidomide ameliorate vincristine-induced hyperalgesia in rats

scientific article published on 3 July 2004

Cyclosporine affects central nervous system opioid activity via direct and indirect means

scientific article published in September 1988

DRG Voltage-gated Sodium Channel 1.7 is Up-regulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.

scientific article published on 18 December 2017

Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat.

scientific article published on January 1992

Differential modification of morphine and methadone dependence by interferon alpha

scientific article published on 01 November 1987

Distribution of cardiovascular related cells within the human thalamus

scientific article published in June 1998

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

scientific article published on 12 March 2016

Dynamic effects of TNF-α on synaptic transmission in mice over time following sciatic nerve chronic constriction injury

scientific article

Dysfunction in Multiple Primary Afferent Fiber Subtypes Revealed By Quantitative Sensory Testing in Patients with Chronic Vincristine-Induced Pain

scientific article published on 01 February 2007

Effect of Fenoldopam on Ischemia/Reperfusion-Induced Apoptosis

scientific article published on 01 January 2006

Effects of isoflurane, pentobarbital, and urethane on apoptosis and apoptotic signal transduction in rat kidney

scientific article published on 15 September 2006

Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats

scientific article published in April 1990

Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathy

scientific article

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of N-methyl-D-aspartic acid and substance P.

scientific article published in October 1991

Evidence of an immune system to brain communication axis that affects central opioid functions: muramyl peptides attenuate opiate withdrawal

scientific article

Evidence of neuro-immunologic interactions: cyclosporine modifies opiate withdrawal by effects on the brain and immune components

scientific article published on January 1987

Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus

scientific article published in July 1996

Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy

scientific article published on 29 January 2012

Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus

scientific article published in April 1998

Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients

scientific article

Functional plasticity in primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord

scientific article published on 01 January 2000

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

scientific article published on 01 October 1994

Gabapentin produces dose-dependent antinociception in the orofacial formalin test in the rat.

scientific article

Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia

scientific article

Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis

scientific article

Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy

scientific article published on 31 May 2013

Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids

article

Internal pallidal neuronal activity during mild drug-related dyskinesias in Parkinson's disease: decreased firing rates and altered firing patterns

scientific article published on 10 January 2007

Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline

scientific article

Irradiation exposure modulates central opioid functions

scientific article published on November 1987

Is Chemotherapy-induced Peripheral Neuropathy More Than Just a Peripheral Nervous System Disorder?

scientific article

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

scientific article published on 01 February 1993

MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy

scientific article

Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment Scale

scientific article

Mechanical and thermal hypersensitivity develops following kainate lesion of the ventral posterior lateral thalamus in rats

scientific article published on 01 August 2000

Microiontophoresis of cocaine, desipramine, sulpiride, methysergide, and naloxone in habenula and parafasciculus

scientific article published in June 1990

Microiontophoretic application of muramyl-dipeptide upon single cortical, hippocampal and hypothalamic neurons in rats

scientific article published on November 1990

Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes.

scientific article

Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist

scientific article

Monkey insular cortex neurons respond to baroreceptive and somatosensory convergent inputs

scientific article published on 01 January 1999

Muramyl-dipeptide, a macrophage-derived cytokine, alters neuronal activity in hypothalamus and hippocampus but not in the dorsal raphe/periaqueductal gray of rats

scientific article published in August 1990

Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

article

Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve

scientific article published on 01 January 1992

Neural changes in acute arthritis in monkeys. III. Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord

article

Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn

scientific article published on 01 January 1992

Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy.

scientific article published in September 1991

Neuronal activity in the region of the thalamic principal sensory nucleus (ventralis caudalis) in patients with pain following amputations

scientific article published in October 1998

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

scientific article published on 20 November 2018

Noninvasive subthreshold auricular electrical stimulation reduces the severity of precipitated and abrupt opiate withdrawal

scientific article published in January 1993

Opiate antinociception is altered by immunemodification: the effect of interferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity

scientific article published in October 1986

Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity

scientific article

Pain Encoding in the Human Forebrain: Binary and Analog Exteroceptive Channels

scientific article published on 01 July 2004

Pain and Temperature Encoding in the Human Thalamic Somatic Sensory Nucleus (Ventral caudal): Inhibition-Related Bursting Evoked by Somatic Stimuli

scientific article published on 18 May 2005

Painful Hands and Feet After Cancer Treatment: Inflammation Affecting the Mind-Body Connection

scientific article published on 23 December 2015

Pallidotomy for hemiballismus: efficacy and characteristics of neuronal activity

scientific article published in November 1997

Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats.

scientific article published in April 1987

Patterns of bursting occurring in thalamic cells during parkinsonian tremor

scientific article published in March 1998

Peripheral neuropathic pain: signs, symptoms, mechanisms, and causes: are they linked?

scientific article published on 24 September 2014

Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine

scientific article published on 11 December 2012

Physiological changes in primate somatosensory thalamus induced by deafferentation are dependent on the spinal funiculi that are sectioned and time following injury

scientific article published in January 2003

Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation

scientific article published on 26 March 2009

Postoperative MRI Evaluation of a Radiofrequency Cordotomy Lesion for Intractable Cancer Pain.

scientific article

Prechemotherapy Touch Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer

scientific article published on 17 February 2016

Psychophysical elements of place and modality specificity in the thalamic somatic sensory nucleus (ventral caudal, vc) of awake humans

scientific article published on 28 September 2005

Quantitative Sensory Findings in Patients With Bortezomib-Induced Pain

scientific article published on 15 December 2006

Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated rats

scientific article

Relationship of membrane properties, spike burst responses, laminar location, and functional class of dorsal horn neurons recorded in vitro

scientific article published on 22 June 2016

Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats

scientific article

Responses of primate spinomesencephalic tract cells to intradermal capsaicin

scientific article published in January 1999

Reversing tissue injury-induced plastic changes in the spinal cord: the search for the magic bullet

scientific article published in September 2000

Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents

scientific article

Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin

scientific article

Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy

scientific article published on 13 November 2014

Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity

scientific article published on February 2013

Spinal cord stimulation relieves chemotherapy-induced pain: a clinical case report

scientific article

Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.

scientific article published in September 2005

Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

scientific article published on 29 March 2008

Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury.

scientific article

Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain

scientific article published in September 1995

Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density

scientific article

Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy

scientific article published on 10 April 2012

Subclinical pretreatment sensory deficits appear to predict the development of pain and numbness in patients with multiple myeloma undergoing chemotherapy

scientific article published on 31 March 2013

Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes

scientific article published on July 2009

Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients

scientific article published in May 2004

The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

scientific article

The brain and the immune system: an intact immune system is essential for the manifestation of withdrawal in opiate addicted rats

scientific article published in January 1990

The effect of alpha-interferon, cyclosporine A, and radiation-induced immune suppression on morphine-induced hypothermia and tolerance

scientific article published on December 1986

The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons

scientific article

The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats

scientific article published on 09 July 2008

The endogenous lectin RL-29 is transynaptically induced in dorsal horn neurons following peripheral neuropathy in the rat.

scientific article published in August 1993

The immune system and opiate withdrawal

scientific article published on 01 January 1989

The sensation of angina can be evoked by stimulation of the human thalamus

scientific article published in October 1994

Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy

scientific article

Trans-cranial electrical stimulation attenuates abrupt morphine withdrawal in rats assayed by remote computerized quantification of multiple motor behavior indices

scientific article published on 01 January 1990

Trans-cranial electrical stimulation attenuates the severity of naloxone-precipitated morphine withdrawal in rats

scientific article published on 01 January 1989

Transient inhibition of responses to thermal stimuli of spinal sensory tract neurons in monkeys during sensitization by intradermal capsaicin

article

Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease

scientific article

Tuning of Membrane Properties Regulates Subliminal Synapses in Dorsal Horn Neurons of Intact Rats

scientific article published on 01 May 2002

Two pains at once: how can you tell which is worse?

scientific article

Wireless peripheral nerve stimulation increases pain threshold in two neuropathic rat models

scientific article published on 01 April 2012