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List of works by Thomas Mercher

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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

scientific article
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

scientific article
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

scientific article published on 14 February 2006
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

scientific article published on June 2010
Activating alleles of JAK3 in acute megakaryoblastic leukemia

scientific article published on July 2006
Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

scientific article
Acquired initiating mutations in early hematopoietic cells of CLL patients

scientific article
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

scientific article published on 21 May 2013
Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

scientific article published on September 2008
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

scientific article published on 27 June 2006
RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

scientific article
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

scientific article
Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export

scientific article
JAK3: a two-faced player in hematological disorders

scientific article published on 09 September 2009
Ott1(Rbm15) has pleiotropic roles in hematopoietic development

scholarly article
Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

scientific article published on 12 January 2009
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

scientific article
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

scientific article
DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

scientific article published on 15 February 2016
Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

scientific article published on 12 November 2009
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

scientific article
Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7.

scientific article published on January 2002
STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

scientific article published on 19 July 2013
Developmental changes in human megakaryopoiesis.

scientific article published in September 2013
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

scientific article published on 18 January 2013
OTT-MAL is a deregulated activator of serum response factor-dependent gene expression

scientific article published on 18 August 2008
STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

scientific article
TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

scientific article published on August 2014
ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

scientific article published in March 2017
A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells

scientific article published on February 2012
AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes.

scientific article published on 11 January 2018
B-cell tumor development in -deficient mice

article
Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

scientific article published on 21 May 2010
TET2, a tumor suppressor in hematological disorders.

scientific article published on 03 January 2012
Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

scientific article published on 19 June 2018
Novel ETO2-GLIS2 fusion and therapeutic strategy in acute megakaryoblastic leukemia

scientific article published on 12 November 2012
Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.

scientific article published on 18 August 2017
FoxO: stress or eternal life

scientific article
Fondements moléculaires de la translocation t(1;22)(p13;q13) des leucémies aiguës à mégacaryoblastes

scientific article published on 01 February 2003
Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

scientific article published on 01 July 2018
Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

scientific article published on 27 March 2020
Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

scientific article
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

scientific article published on 24 April 2019
Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia.

scientific article
TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

A Novel Developmental Gene Expressed in Late Gestation Lung Identified Using Representational Difference Analysis

Recurrent TET2 mutations in adult T cell leukemia.

scientific article published on 7 January 2014
Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

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