List of works - Sergey Kochetkov

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

scientific article

5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis

scientific article published on 9 June 2015

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

scientific article

Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.

scientific article

Benzohydroxamic acids as potent and selective anti-HCV agents.

scientific article published on 27 August 2013

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.

scientific article published on October 2012

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

scientific article published on 8 May 2012

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

scientific article

Determination of binding parameters of cyclic AMP and its analogs to cyclic AMP-dependent protein kinase by the fluorescent probe method ⬇️

scientific article published on August 15, 1979

Determination of the melting site of the DNA duplex in the active center of bacterial RNA-polymerase by fluorescence quenching technique.

scientific article published in September 2007

Dual-targeted anti-TB/anti-HIV heterodimers

scientific article

Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells

scientific article published on May 2016

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

scientific article published on 27 February 2015

Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines

scientific article published on 01 September 2015

Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv

scientific article published in September 2011

Evaluation of the antiprotozoan properties of 5'-norcarbocyclic pyrimidine nucleosides.

scientific article published on 17 May 2017

Gene immunization may induce secondary antibodies reacting with DNA.

scientific article published in March 2004

HCV and oxidative stress in the liver.

scientific article published on 28 January 2013

HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

scientific article published on 29 May 2015

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

scientific article published on 02 December 2019

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

scientific article published on 20 April 2016

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

scientific article published on 03 September 2019

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.

scientific article

Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.

scientific article published in September 2006

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism

scientific article published on 9 January 2017

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.

scientific article published on June 2008

Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

scientific article

Hepatitis C virus: The role of N-glycosylation sites of viral genotype 1b proteins for formation of viral particles in insect and mammalian cells.

scientific article published on 30 May 2016

Human herpes simplex virus: life cycle and development of inhibitors

scientific article

Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

scientific article published on 22 July 2016

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

scientific article published on December 2013

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

scientific article published on 01 September 2000

Interaction of tRNA-derivatives and oligonucleotide primers with AZT-resistant mutants of HIV-1 reverse transcriptase.

scientific article published in November 1998

Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.

scientific article

Isolation of the regulatory subunit of pig-brain histone kinase by affinity chromatography on cyclic-AMP-containing adsorbent

scientific article published in December 1974

Low-molecular-weight regulators of biogenic polyamine metabolism affect cytokine production and expression of hepatitis С virus proteins in Huh7.5 human hepatocarcinoma cells

scientific article published on May 2017

Lys631 residue in the active site of the bacteriophage T7 RNA polymerase. Affinity labeling and site-directed mutagenesis ⬇️

scientific article published on February 14, 1991

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

article

Methylated polyamines as research tools

scientific article published on 01 January 2011

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

scientific article

Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.

scientific article published on 6 November 2017

Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site.

scientific article published on 25 May 2007

Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction

scientific article published on 01 February 1998

Mutants of T7 RNA polymerase that are able to synthesize both RNA and DNA

scientific article published on 01 August 1995

Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.

scientific article published on February 2004

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

scientific article published on 3 January 2013

New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

scientific article published on July 2004

Novel 5-substituted derivatives of 2'-deoxy-6-azauridine with antibacterial activity

scientific article published on 21 February 2019

Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

scientific article published on 01 May 2003

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

scientific article published on 23 June 2017

On the functional role of the Tyr-639 residue of bacteriophage T7 RNA polymerase

scientific article published on 01 July 1992

Oxidative Stress during HIV Infection: Mechanisms and Consequences

scientific article

Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization.

scientific article published on 23 July 2013

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

scientific article

Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.

scientific article

Physico-chemical principles of cAMP-dependent protein phosphorylation. Catalysis of phosphoryl group transfer to nucleophilic agents

scientific article published in July 1984

Potent cross-reactive immune response against the wild-type and drug-resistant forms of HIV reverse transcriptase after the chimeric gene immunization.

scientific article published in February 2010

Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6.

scientific article published on 16 April 2015

Random mutagenesis of the gene for bacteriophage T7 RNA polymerase

scientific article published on 01 April 1993

Recent studies of T7 RNA polymerase mechanism

scientific article published on 01 December 1998

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.

scientific article

Role of a histidine residue in the active site of cyclic AMP-dependent histone kinase ⬇️

scientific article published on December 1, 1976

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

scientific article

Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes.

scientific article

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

scientific article published on 12 December 2013

Studies on the Mechanism of Action of Histone Kinase Dependent on Adenosine 3':5'-Monophosphate. Evidence for Involvement of Histidine and Lysine Residues in the Phosphotransferase Reaction ⬇️

scientific article published on November 15, 1977

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Fast kinetics of histone H1 phosphorylation.

scientific article published in October 1983

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Interaction of ATP with the catalytic subunit of the pig-brain enzyme: application of the quenched-flow technique.

scientific article published in April 1981

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Investigation of protein-protein interaction by electron spin-resonance spectroscopy and stopped-flow methods

scientific article published on 01 May 1983

Substrate properties of C'-methyl UTP derivatives in T7 RNA polymerase reactions. Evidence for N-type NTP conformation

scientific article published on 01 January 1997

Synthesis and anti-HIV properties of new carbamate prodrugs of AZT.

scientific article published on 9 October 2012

Synthesis and biological characterization of novel charge-deficient spermine analogues.

scientific article published on August 2010

Synthesis and biological properties of pyrimidine 4'-fluoro nucleosides and 4'-fluoro uridine 5'-O-triphospate

scientific article published on July 2010

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

scientific article

Synthesis of mixed ribo/deoxyribopolynucleotides by mutant T7 RNA polymerase

scientific article published on 01 November 1998

Targeted mutagenesis identifies Asp-569 as a catalytically critical residue in T7 RNA polymerase

scientific article published on 01 April 1995

The studies of cooperative regions in T7 RNA polymerase.

scientific article published in August 1994

The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.

scientific article

The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase

scientific article published on January 2015

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

scientific article published on 3 June 2011

Tyr-571 is involved in the T7 RNA polymerase binding to its promoter

scientific article published on 01 March 1993

Versatile synthesis of oxime-containing acyclic nucleoside phosphonates--synthetic solutions and antiviral activity

scientific article published on 18 September 2015

[Novel metabolically stable functionally-active mimetic of spermidine]

scientific article published on 01 March 2011

[Role of N-linked glycans in HCV glycoprotein E1 in the folding of structural proteins and formation viral particles].

scientific article published in January 2013

List of works by Sergey Kochetkov

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.

Benzohydroxamic acids as potent and selective anti-HCV agents.

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

Determination of binding parameters of cyclic AMP and its analogs to cyclic AMP-dependent protein kinase by the fluorescent probe method ⬇️

Determination of the melting site of the DNA duplex in the active center of bacterial RNA-polymerase by fluorescence quenching technique.

Dual-targeted anti-TB/anti-HIV heterodimers

Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines

Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv

Evaluation of the antiprotozoan properties of 5'-norcarbocyclic pyrimidine nucleosides.

Gene immunization may induce secondary antibodies reacting with DNA.

HCV and oxidative stress in the liver.

HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.

Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.

Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

Hepatitis C virus: The role of N-glycosylation sites of viral genotype 1b proteins for formation of viral particles in insect and mammalian cells.

Human herpes simplex virus: life cycle and development of inhibitors

Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

Interaction of tRNA-derivatives and oligonucleotide primers with AZT-resistant mutants of HIV-1 reverse transcriptase.

Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.

Isolation of the regulatory subunit of pig-brain histone kinase by affinity chromatography on cyclic-AMP-containing adsorbent

Low-molecular-weight regulators of biogenic polyamine metabolism affect cytokine production and expression of hepatitis С virus proteins in Huh7.5 human hepatocarcinoma cells

Lys631 residue in the active site of the bacteriophage T7 RNA polymerase. Affinity labeling and site-directed mutagenesis ⬇️

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

Methylated polyamines as research tools

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.

Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site.

Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction

Mutants of T7 RNA polymerase that are able to synthesize both RNA and DNA

Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Novel 5-substituted derivatives of 2'-deoxy-6-azauridine with antibacterial activity

Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

On the functional role of the Tyr-639 residue of bacteriophage T7 RNA polymerase

Oxidative Stress during HIV Infection: Mechanisms and Consequences

Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization.

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.

Physico-chemical principles of cAMP-dependent protein phosphorylation. Catalysis of phosphoryl group transfer to nucleophilic agents

Potent cross-reactive immune response against the wild-type and drug-resistant forms of HIV reverse transcriptase after the chimeric gene immunization.

Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6.

Random mutagenesis of the gene for bacteriophage T7 RNA polymerase

Recent studies of T7 RNA polymerase mechanism

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.

Role of a histidine residue in the active site of cyclic AMP-dependent histone kinase ⬇️

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes.

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

Studies on the Mechanism of Action of Histone Kinase Dependent on Adenosine 3':5'-Monophosphate. Evidence for Involvement of Histidine and Lysine Residues in the Phosphotransferase Reaction ⬇️

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Fast kinetics of histone H1 phosphorylation.

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Interaction of ATP with the catalytic subunit of the pig-brain enzyme: application of the quenched-flow technique.

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Investigation of protein-protein interaction by electron spin-resonance spectroscopy and stopped-flow methods

Substrate properties of C'-methyl UTP derivatives in T7 RNA polymerase reactions. Evidence for N-type NTP conformation

Synthesis and anti-HIV properties of new carbamate prodrugs of AZT.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Synthesis and biological properties of pyrimidine 4'-fluoro nucleosides and 4'-fluoro uridine 5'-O-triphospate

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

Synthesis of mixed ribo/deoxyribopolynucleotides by mutant T7 RNA polymerase

Targeted mutagenesis identifies Asp-569 as a catalytically critical residue in T7 RNA polymerase

The studies of cooperative regions in T7 RNA polymerase.

The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.

The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase