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List of works by Maurizio Bifulco

"Adiponcosis": a new term to name the obesity and cancer link

scientific article published on 9 October 2013

1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor

scientific article published on 21 January 2014

A focus on Trotula dé Ruggiero: a pioneer in women's and children's health in history of medicine

scientific article published on 5 June 2013

A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis

scientific article

A new role of anandamide in human sperm: focus on metabolism.

scientific article published in October 2009

A new strategy to block tumor growth by inhibiting endocannabinoid inactivation

scientific article

Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration.

scientific article

Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells.

scientific article published on 12 October 2006

Anandamide inhibits adhesion and migration of breast cancer cells

scientific article published on 15 December 2005

Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells

scientific article published on 21 February 2013

Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells.

scientific article

Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines

scientific article published on 20 April 2015

Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy

scientific article published on May 2007

Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation.

scientific article

Antibiotics exposure in obesity: an update of a complex relationship

scientific article published on 20 November 2014

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

scientific article (publication date: September 2006)

Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression

scientific article published on 01 November 1999

Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells

scientific article published on 05 March 2007

Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis

scientific article published on 18 October 2005

Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors

scientific article

Ascorbate administration to normal and cholesterol-fed rats inhibits in vitro TBARS formation in serum and liver homogenates

scientific article published on 01 January 1996

Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population

scientific article published on 12 December 2006

Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects

scientific article published on 26 June 2009

Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity.

scientific article published on September 2004

Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights

scientific article published on 19 November 2010

Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug

scientific article published on February 2008

Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress.

scientific article published on 20 September 2008

Calcium/Calmodulin-dependent protein kinase II and its endogenous inhibitor α in medullary thyroid cancer.

scientific article published on 21 January 2014

Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation.

scientific article

Cannabinoid receptor 1 antagonism in hepatocellular carcinoma: killing two birds with one stone

scientific article published on 01 June 2015

Cannabinoid receptor CB1 antagonists state of the art and challenges.

scientific article published on January 2009

Cannabinoid type 1 receptor gene polymorphism and macronutrient intake

scientific article published on 27 November 2012

Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder

scientific article (publication date: 15 August 2003)

Characterization of the low density lipoprotein receptor activity in buffalo rat liver (BRL-3A) cells

scientific article published on March 1, 1992

Comment on "the negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia.".

scientific article published in March 2015

Comment on 'When in Rome, reform'.

scientific article published on 13 March 2009

Comments on Triassi et al. Environmental pollution from illegal waste disposal and health effects: a review on the "Triangle of Death". Int. J. Environ. Res. Public health 2015, 12, 1216-1236.

scientific article published on 19 March 2015

Concomitant BRAF(V600E) mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma

scientific article published on 24 August 2013

Control of Rab5 and Rab7 expression by the isoprenoid pathway

scientific article published on July 1998

Debate on adverse effects of statins

scientific article published on 16 September 2014

Dietary and hypothyroid hypercholesterolemia induces hepatic apolipoprotein E expression in the rat: direct role of cholesterol

scientific article published on 01 December 1999

Dietary recommendations in the medieval Medical School of Salerno: a lesson from the past

scientific article published on 01 December 2008

Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells.

scientific article published on July 2002

Effect of unsaturated fat intake from Mediterranean diet on rat liver mRNA expression profile: selective modulation of genes involved in lipid metabolism.

scientific article

Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems

scientific article

Effects of a new calf thymus protein on 3-hydroxy-3-methylglutaryl-CoA reductase activity in rat (Rattus bubalus) hepatocyte cells (BRL-3A)

scientific article published on October 1, 1992

Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.

scientific article

Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis

scientific article

Endocannabinoid system modulation in cancer biology and therapy.

scientific article published on 24 March 2009

Endocannabinoids and multiple sclerosis: a blessing from the 'inner bliss'?

scientific article

Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

scientific article

Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines

scientific article published on January 2008

Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells.

scientific article published on December 2005

Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex

scientific article published on 01 January 2006

Free fatty acids modulate LDL receptor activity in BHK-21 cells.

scientific article published on April 1998

From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches

scientific article published on 01 January 2007

Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis.

scientific article

HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway

scientific article published on 01 September 2006

Helicobacter pylori has stimulatory effects on naive T cells

scientific article published in February 2006

Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction.

scientific article published in February 2010

Identification of a 48-kDa prenylated protein that associates with microtubules as 2',3'-cyclic nucleotide 3'-phosphodiesterase in FRTL-5 cells

scientific article published on August 1997

Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives

scientific article published in October 2013

In memory of Nino Salvatore: tenth anniversary

scientific article published in January 2008

In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake

scientific article published in January 2004

Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.

scientific article

Increased levels of DHEAS in serum of patients with X-linked ichthyosis

scientific article published on 01 January 1991

Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.

scientific article published on 18 May 2010

Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells

scientific article published on April 1999

Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells

scientific article published on December 1996

Integrating Medical Humanities into medical school training

scientific article published on 30 October 2019

Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth.

scientific article published on January 2012

Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression

scientific article published on 18 January 2010

Involvement of Akt/NF-κB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells.

scientific article published on October 2010

Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells

scientific article published on April 2011

Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells

scientific article published on 9 August 2007

Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state

scientific article published on 9 September 2008

Medical Cannabis: A plurimillennial history of an evergreen

scientific article published on 11 November 2018

Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs

scientific article published on 20 June 2007

N6-isopentenyladenosine affects cAMP-dependent microfilament organization in FRTL-5 thyroid cells

scientific article published on 01 July 1997

N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice.

scientific article

N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

scientific article published on March 2006

N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A.

scientific article published on 18 November 2013

N6-isopentenyladenosine induces cell death through necroptosis in human glioblastoma cells

scientific article published on 07 April 2022

N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1.

scientific article

N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation.

scientific article published on 11 July 2013

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity

scientific article published on 24 April 2015

Novel prospects of statins as therapeutic agents in cancer

scientific article published on 05 July 2014

Novel role for cannabidiol in circadian clock function

scientific article published on 27 May 2019

Oxylipins from Dracontium loretense.

scientific article

PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

scientific article published on 16 July 2013

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

scientific article

Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer ⬇️

scientific article published on November 21, 2011

Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells

scientific article published on 24 October 2005

Possible endocannabinoid control of colorectal cancer growth

scientific article published in September 2003

Possible relationship between statin use and decreased prevalence, number, and volume of thyroid nodules: a new indication for these drugs?

scientific article published on 01 September 2007

Potential therapeutic role of statins in neurological disorders.

scientific article published on May 2008

Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism

scientific article published on February 1999

Presence of CuZn superoxide dismutase in human serum lipoproteins

scientific article published on 01 February 2000

Protection of human endothelial cells from oxidative stress: role of Ras-ERK1/2 signaling.

scientific article published in February 2002

Purification and characterization of a calf thymus protein active on lipid metabolism

scientific article published on 01 January 1989

Ras oncoprotein disrupts the TSH/CREB signaling upstream adenylyl cyclase in human thyroid cell.

scientific article published on December 2014

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

scientific article

Recognition by natural killer cells of N6-isopentenyladenosine-treated human glioma cell lines

scientific article published on 7 September 2017

Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer".

scientific article published in July 2008

Retraction notice to “PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines” [Eur. J. Pharmacol. 714(1–3) (2013) 379–387]

scientific article published on 01 April 2014

Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells

scientific article published on 24 December 2007

Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm

scientific article

Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon.

scientific article published in September 2009

Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice

scientific article published on January 2011

Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways

scientific article published on 24 April 2010

Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects.

scientific article published on 27 February 2007

Risk of diabetes with statins must be monitored in each patient ⬇️

scientific article published on 02 July 2013

Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis.

scientific article

Role of the small GTPase Rab7 in the late endocytic pathway.

scientific article published on February 1997

Serum withdrawal-induced apoptosis in thyroid cells is caused by loss of fibronectin-integrin interaction

scientific article

Statin: new life for an old drug

scientific article published on 14 July 2014

Statins and cancer in gastroenterology: new insight?

scientific article published on 28 April 2013

Statins and cancer-related mortality: an open question

scientific article published on 25 May 2013

Statins in neurological disorders: an overview and update.

scientific article

Structures and micelle locations of the nonlipidated and lipidated C-terminal membrane anchor of 2',3'-cyclic nucleotide-3'-phosphodiesterase

scientific article published on 13 December 2007

Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.

scientific article

Targeting the endocannabinoid system in cancer therapy: a call for further research

scientific article

The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice.

scientific article

The N-terminal domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase harbors a GTP/ATP binding site

scientific article published on 6 November 2007

The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway

scientific article

The basis of the modern medical hygiene in the medieval Medical School of Salerno

scientific article published on 30 September 2014

The benefit of statins in SARS-CoV-2 patients: further metabolic and prospective clinical studies are needed

scientific article published on 20 November 2020

The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism

scientific article published on 5 July 2006

The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase

scientific article published on 18 September 2008

The endocannabinoid signaling system in cancer

scientific article published on 17 April 2013

The endocannabinoid system and its therapeutic exploitation

scientific article published in September 2004

The endocannabinoid system: from biology to therapy

scientific article published on 15 May 2009

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.

scientific article

The first cosmetic treatise of history. A female point of view.

scientific article

The isoprenoid derivative N6 -benzyladenosine CM223 exerts antitumor effects in glioma patient-derived primary cells through the mevalonate pathway.

scientific article published on 18 April 2017

The obesity and cancer link

scientific article published on 18 November 2014

The right to care and the expectations of society--controversial stem cell therapy in Italy

scientific article published on 4 June 2013

The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells

scientific article (publication date: 5 March 1999)

Therapeutic potential of statins in thyroid proliferative disease.

scientific article published on 26 February 2008

Thymus fraction (FIII) effect on cholesterol metabolism: modulation of the low density lipoprotein receptor pathway

scientific article published in January 1989

Thyroid adiponcosis: more than an hypothesis

scientific article published on 02 September 2014

Thyroid cellular models: a warning concerning their application

scientific article published in September 2009

Thyroidology in the Medieval Medical School of Salerno

scientific article (publication date: 2007)

Thyrotropin interaction with high-density lipoproteins

scientific article published in 1985

Trotula de Ruggiero: The Magistra mulier sapiens and her medical dermatology treatises

scientific article published on 25 February 2019

Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors

scientific article published on August 1999

Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.

scientific article published on February 2009

Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins.

scientific article

What we know and do not know about the cannabinoid receptor 2 (CB2)

scientific article

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