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List of works by Michael Simons

"On-target" cardiac effects of anticancer drugs: lessons from new biology

scientific article

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

scientific article

Abnormalities in the regulators of angiogenesis in patients with scleroderma

scientific article

Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition

scientific article published on 06 March 2008

Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation

scientific article published on 27 October 2005

Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells

scientific article published on 19 November 2020

An anti-CD11/CD18 monoclonal antibody in patients with acute myocardial infarction having percutaneous transluminal coronary angioplasty (the FESTIVAL study)

scientific article published on 01 September 2001

Angiogenesis in cardiovascular disease: current status and therapeutic potential.

scientific article

Angiogenesis in ischemic heart disease

scientific article published on February 1997

Angiogenesis in the human heart: gene and cell therapy.

scientific article

Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling

scientific article published on 03 March 2015

Angiogenesis, arteriogenesis, and diabetes: paradigm reassessed?

scientific article published on 01 September 2005

Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia

scientific article published on 11 October 2004

Angiographic methods to assess human coronary angiogenesis

scientific article published on 01 January 1999

Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.

scientific article

Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism

scientific article

Antiangiogenic plasma activity in patients with systemic sclerosis

scientific article published on 01 October 2007

Antisense approach to restenosis

scientific article published on January 1996

Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents

scientific article

Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis

scientific article published on 01 February 1992

Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a.

scientific article published in July 1999

Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

scientific article published on 15 August 2019

Auxiliary and Autonomous Proteoglycan Signaling Networks ⬇️

scientific article published on January 1, 2010

Beta-adrenergic modulation of the collateral-dependent coronary microcirculation

scientific article published on 01 July 1995

Branching morphogenesis.

scientific article published on January 2009

Calling on reserves: granulocyte colony stimulating growth factor in cardiac repair

scientific article published on 01 November 2005

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

scientific article published on 16 April 2015

Cell communications in the heart.

scientific article published on August 2010

Chapter 14. Assessment of arteriogenesis

scientific article

Characterization of synectin expression and promoter activity

scientific article

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis

scientific article

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion.

scientific article published on 15 August 2008

Comparison of VEGF delivery techniques on collateral-dependent microvascular reactivity

scientific article published on 01 March 1998

Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs

scientific article published in September 2006

Copper chelation represses the vascular response to injury

scientific journal article

Correlation approach to identify coding regions in DNA sequences

scientific article

Current concepts in normal and defective angiogenesis: implications for systemic sclerosis.

scientific article published on May 2007

Delayed arteriogenesis in hypercholesterolemic mice

scientific journal article

Diabetic monocyte and vascular endothelial growth factor signaling impairment.

scientific article

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

scientific article

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

scientific article

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis

scientific article

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.

scientific article

Effect of sialyl Lewis(x) oligosaccharide on myocardial and cerebral injury in the pig.

scientific article

Effects of cell grafting on coronary remodeling after myocardial infarction.

scientific article published on 30 May 2013

Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia.

scientific article

Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia

scientific article published on 01 December 2000

Embryonic coronary vasculogenesis and angiogenesis are regulated by interactions between multiple FGFs and VEGF and are influenced by mesenchymal stem cells.

scientific article

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

scientific article

Endothelial ERK signaling controls lymphatic fate specification ⬇️

scientific article published on February 8, 2013

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

scientific article published on 13 June 2019

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

scientific article published on 25 March 2013

Endothelial cell-dependent regulation of arteriogenesis

scientific article

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

scientific article

Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling

scientific article

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching

scientific article published on 22 October 2012

Endothelial signaling and the molecular basis of arteriovenous malformation

scientific article published on 28 September 2013

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization ⬇️

scientific article published on October 28, 2011

Endothelial-to-mesenchymal transition drives atherosclerosis progression

scientific article

Endothelium as master regulator of organ development and growth.

scientific article published on 05 September 2008

Endothelium-driven myocardial growth or nitric oxide at the crossroads.

scientific article

Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells

scientific article published on March 1997

Evolving revascularization approaches for myocardial ischemia

scientific article published in November 2003

Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia

scientific article

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression ⬇️

scientific article published on November 29, 2012

FGF-dependent regulation of VEGF receptor 2 expression in mice ⬇️

scientific article published on July 1, 2011

FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression

scientific article

Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway

scientific article published on July 2004

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

scientific article published on 23 September 2014

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2

scientific article

Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice

scientific article published on 13 September 2012

Finite-size effects on long-range correlations: implications for analyzing DNA sequences

scientific article published in May 1993

Flow-regulated lymphatic vasculature development and signaling

scientific article

Food for starving hearts

scientific article published on 01 May 1996

Fox(y) regulators of VEGF receptors

scientific article published on September 2014

Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family

scientific article

Fractals in biology and medicine

scientific article

Gene therapy versus protein-based therapy: a matter of pharmacokinetics

scientific article

Gene transfer for angiogenesis in coronary artery disease.

scientific article

Generalized Lévy-walk model for DNA nucleotide sequences

scientific article published in June 1993

Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: implications for tumor angiogenesis

scientific article

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb.

scientific article

Humoral and cellular factors responsible for coronary collateral formation

scientific article published on 31 August 2006

Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries

scientific article published on 26 May 2006

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

scientific article

Integrative signaling in angiogenesis.

scientific article

Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis

scientific article (publication date: 2014)

Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease

scientific article published on November 2001

Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study.

scientific article

Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization

scientific article published on 01 July 2001

Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis

scientific article published on 21 December 2019

Lacteal junction zippering protects against diet-induced obesity.

scientific article published in August 2018

Linguistic features of noncoding DNA sequences

scientific article published in December 1994

Live 3D echo guidance of catheter-based endomyocardial injection

scientific article published in July 2005

Long-range correlation properties of coding and noncoding DNA sequences: GenBank analysis

scientific article

Long-range correlations in nucleotide sequences

scientific article

Long-range fractal correlations in DNA

scientific article published in Physical Review Letters

Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein

scientific article published on 01 July 2002

Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

scientific article published in February 2002

Lymphatic fate determination: playing RAF with ERK.

scientific article published on 2 April 2013

Lymphatic fate specification: an ERK-controlled transcriptional program

scientific article

Lymphatics thrive on stress: mechanical force in lymphatic development ⬇️

scientific article published on February 15, 2012

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

scientific article

Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization.

scientific article

Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis

scientific article

Micro computed tomography for vascular exploration.

scientific article published on 05 March 2010

Modulation of microvascular signaling by heparan sulfate matrix: studies in syndecan-4 transgenic mice.

scientific article

Molecular basis for proline- and arginine-rich peptide inhibition of proteasome

scientific article published on 16 September 2008

Molecular controls of arterial morphogenesis

scientific article published on May 2015

Molecular controls of lymphatic VEGFR3 signaling

scientific article published on 18 December 2014

Molecular multitasking: statins lead to more arteries, less plaque

scientific article published on 01 September 2000

Mosaic organization of DNA nucleotides

scientific article

Myb-dependent regulation of thrombospondin 2 expression. Role of mRNA stability

scientific article published on August 1998

Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression

scientific article published on 01 May 1999

Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse

scientific article published on 12 August 2015

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization

scientific article published on 05 April 2019

Need glucose to sprout: local metabolic control of angiogenesis

scientific article published on 27 August 2013

Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.

scientific article published on 15 July 2008

Non-canonical fibroblast growth factor signalling in angiogenesis.

scientific article published on 04 December 2007

Non-equilibrium dynamics as an indispensable characteristic of a healthy biological system

scientific article published on July 1994

PKCalpha activates eNOS and increases arterial blood flow in vivo

scientific article published on 04 August 2005

PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2.

scientific article published on 15 March 2004

PR39, a peptide regulator of angiogenesis

scientific article published on 01 January 2000

PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.

scientific article

Pharmacokinetics and pharmacodynamics of recombinant FGF-2 in a phase I trial in coronary artery disease

scientific article published on 01 April 2001

Phosphatidylinositol-4,5-bisphosphate mediates the interaction of syndecan-4 with protein kinase C

scientific article published on 01 November 1999

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation

scientific article

Phosphorylation of the Cytoplasmic Tail of Syndecan-4 Regulates Activation of Protein Kinase Cα ⬇️

scientific article published on 01 October 1998

Physiology. Lymphatics are in my veins

scientific article published in August 2013

Plasminogen and plasmin activity in patients with coronary artery disease

scientific article published on 01 June 2006

Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.

scientific article published on 22 February 2017

Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse

scientific article

Profilin phosphorylation as a VEGFR effector in angiogenesis

scientific article published on October 2012

Progress and prospects: cell based regenerative therapy for cardiovascular disease.

scientific article

Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity

scientific article published in July 2003

Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling

scientific article published on April 2007

Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner

scientific article published on 26 March 2002

Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization

scientific article published on 07 May 2019

Recent advances in understanding lymphangiogenesis and metabolism

scientific article published on 20 July 2018

Receptor tyrosine kinases endocytosis in endothelium: biology and signaling

scientific article

Reduced-dose fibrinolytic acceleration of ST-segment elevation myocardial infarction treatment coupled with urgent percutaneous coronary intervention compared to primary percutaneous coronary intervention alone results of the AMICO (Alliance for Myo

scientific article

Regulation of Syndecan-4 Phosphorylation in Vivo ⬇️

scientific article published on May 1, 1998

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

scientific article

Regulation of vascular integrity.

scientific article published on April 2009

Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia

scientific article

Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis

scientific article published on 03 September 2021

Role of angiogenesis in cardiovascular disease: a critical appraisal.

scientific article

Role of synectin in lymphatic development in zebrafish and frogs

scientific article published on 14 July 2010

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

scientific article published in Nature Communications

Selective regulation of arterial branching morphogenesis by synectin

scientific article published in June 2006

Serial motion assessment by reference tracking (SMART): application to detection of local functional impact of chronic myocardial ischemia

scientific article published in July 2001

Silky, sticky chimeras-designer VEGFs display their wares

scientific article published on 01 May 2007

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression

scientific article published on 13 May 2016

Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins

scientific article published on 22 April 2003

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association

scientific article

Statistical and linguistic features of DNA sequences.

scientific article

Statistical properties of DNA sequences.

scientific article

Stem cell therapies in cardiovascular disease A "realistic" appraisal.

scientific article published on January 2008

Subxyphoid access of the normal pericardium: a novel drug delivery technique

scientific article published on 01 May 1999

Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.

scientific article

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development

scientific article published on 27 October 2016

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

scientific article

Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis

scientific article published on 08 May 2012

Syndecan 4 regulation of PDK1-dependent Akt activation

scientific article published on 10 September 2012

Syndecan-4 clustering induces cell migration in a PDZ-dependent manner

scientific article

Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells

scientific article published on October 2008

Syndecan-4 signaling at a glance

scientific article

Syndecan-4-mediated signalling ⬇️

scientific article published on December 1, 2001

Synectin-dependent gene expression in endothelial cells.

scientific article published on 29 August 2006

Synectin-dependent regulation of arterial maturation

scientific article published on March 2009

Synectin/syndecan-4 regulate coronary arteriolar growth during development

scientific article published in July 2007

Systematic analysis of coding and noncoding DNA sequences using methods of statistical linguistics

scientific article

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.

scientific article published on 09 June 2009

The Syndecan-4/Protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo ⬇️

scientific article published on March 22, 2013

The anti-angiogenic activity of rPAI-1(23) inhibits fibroblast growth factor-2 functions.

scientific article

The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature

scientific article published on 4 February 2016

The impact of clinical data on interpretation of thallium scintigrams.

scientific article published in July 1994

The molecular basis of endothelial cell plasticity.

scientific article published on 9 February 2017

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis

scientific article

The role of syndecan cytoplasmic domain in basic fibroblast growth factor-dependent signal transduction

scientific article published on August 1999

Therapeutic angiogenesis for critical limb ischemia: design of the hepatocyte growth factor therapeutic angiogenesis clinical trial

scientific article published on 01 May 2004

Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results

scientific article published in June 1998

Transcriptional Profiling in Coronary Artery Disease

scholarly article by Thomas W. Chittenden et al published 24 October 2006 in Circulation

Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.

scientific article

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

scientific article

VEGF administration in chronic myocardial ischemia in pigs

scientific article published on 01 November 1998

VEGF and restenosis: the rest of the story

scientific article published on April 2009

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis

scientific article published on 6 May 2010

VEGF signaling inside vascular endothelial cells and beyond

scientific article

VEGFR2 trafficking: speed doesn't kill

scientific article published on July 2013

Vasa vasorum in normal and diseased arteries

scientific article

Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency.

scientific article

Vascular disease in scleroderma: angiogenesis and vascular repair.

scientific article published on February 2008

Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.

scientific article published on 21 August 2008

When endothelial cells go rogue

scientific article published on 27 November 2015

When it is better to regress: dynamics of vascular pruning.

scientific article published on 15 May 2015

c-Myb function in fibroblasts

scientific article published on December 1997

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