List of works - Ian Sabroe

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature

scientific article published in September 2009

A matter of time: study of circadian clocks and their role in inflammation

scientific article published on 8 February 2016

A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models.

scientific article

A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains

scientific article published on October 2008

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

scientific article

A social-technological epistemology of clinical decision-making as mediated by imaging

scientific article published on 3 October 2016

ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.

scientific article published in September 2011

Adults' experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies

scientific article published on 07 December 2020

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes

scientific article published on 18 January 2005

Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection

scientific article published on 21 August 2019

Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre

scientific article published on 30 April 2014

Asthma and MIF: innately Th1 and Th2

scientific article published in September 2000

Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension.

scientific article

CCR4 in human allergen-induced late responses in the skin and lung

scientific article published on July 2002

CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry

scientific article

CXCR1+CD4+ T cells in human allergic disease.

scientific article published in January 2004

Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension.

scientific article published on 7 February 2013

Characterisation of the biological activity of recombinant equine eotaxin in vitro

scientific article published on July 2002

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.

scientific article published in June 2004

Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension.

scientific article published on 5 June 2017

Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.

scientific article published on 17 October 2006

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

scientific article

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

scientific article published in April 2018

DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling

scientific article published on 04 January 2019

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

scientific article

Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models

scientific article published on 23 October 2018

Diesel exhaust particle exposure in vitro alters monocyte differentiation and function

scientific article

Diesel exhaust particles override natural injury-limiting pathways in the lung.

scientific article

Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.

scientific article

Editorial: RSV: a new box of delights for an old enemy.

scientific article published in December 2014

Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans

scientific article published in April 2019

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

scientific article

Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response.

scientific article published on 16 April 2008

Endotoxin tolerance induces selective alterations in neutrophil function.

scientific article published on 21 October 2005

Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability

scientific article published on 31 July 2008

Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold

scientific article published on 01 June 2019

Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes

scientific article published on 24 February 2016

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension

scientific article published on 01 February 2020

Idiopathic and Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes.

scientific article published on 18 February 2017

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

scientific article published on 4 October 2007

Incapacitating the immune system in cystic fibrosis

scientific article published in December 2007

Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I.

scientific article published on 21 June 2018

Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension.

scientific article published on 24 April 2017

Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils

scientific article published on 29 April 2002

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

scientific article published on 15 October 2019

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

scientific article published in December 2007

Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension.

scientific article

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

scientific article

Management dilemmas in acute pulmonary embolism

scientific article published on 16 December 2013

Management of acute pulmonary embolism.

scientific article published on October 2015

Measurement of Granulocyte Pharmacodynamics in Whole Blood by Flow Cytometry

scientific article published on 01 January 2001

Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.

scientific article

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

scientific article

Pathophysiology and Diagnosis of Pulmonary Hypertension Due to Left Heart Disease.

scientific article published on 6 June 2018

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

scientific article published on 28 October 2008

Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease

scientific article published on 31 July 2019

Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

scientific article

Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy

scientific article published on 26 December 2014

Physician narratives of illness

scientific article published on 04 July 2019

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

scientific article

Potentiation of TLR4 signalling by plasmin activity

scientific article published on 10 January 2006

Practical and conceptual models of chronic obstructive pulmonary disease.

scientific article published on December 2007

Practical phenotyping of difficult asthma

scientific article published on 31 May 2013

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic-pathophysiologic classification.

scientific article

Pulmonary hypertension in COPD: results from the ASPIRE registry.

scientific article

Pulmonary hypertension: diagnosis and management

scientific article published in the British Medical Journal

Reducing the toll of inflammatory lung disease.

scientific article published on May 2007

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.

scientific article published in May 2005

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

scientific article (publication date: February 2016)

Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists

scientific article

Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.

scientific article published on January 2014

Roles of chemokines in the regulation of leucocyte recruitment

scientific article published on 01 April 2001

Sarcoidosis presenting with chylothorax

scientific article published on December 1995

Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin

scientific article

T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

scientific article

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

scientific article published on 30 November 2006

Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.

scientific article

The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b.

scientific article published on 14 September 2001

The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner

scientific article published in April 2005

The care of dying people in 16th- and 17th-century England

scientific article published on 01 February 2019

The expression and roles of Toll-like receptors in the biology of the human neutrophil.

scientific article

The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands

scientific article published in January 2009

The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody

scientific article

The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension

scientific article published on 16 September 2018

The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry.

scientific article published in April 2019

The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes.

scientific article published on August 2009

The role of TLR activation in inflammation.

scientific article published on January 2008

The role of TLRs in neutrophil activation ⬇️

scientific article published on 06 July 2011

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis

scientific article

The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.

scientific article

The yin and the yang of immunosuppression with inhaled corticosteroids

scientific article published on 8 August 2013

Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis

scientific article published on 11 April 2015

Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension

scientific article published on 01 January 2019

Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease.

scientific article published on December 2007

Toll-like receptors and chronic lung disease.

scientific article

Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin.

scientific article published on November 1995

What can we learn from highly purified neutrophils?

scientific article published on June 2004

“Dirty little secrets”—Endotoxin contamination of recombinant proteins

scientific article published in July 2006

List of works by Ian Sabroe

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature

A matter of time: study of circadian clocks and their role in inflammation

A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models.

A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

A social-technological epistemology of clinical decision-making as mediated by imaging

ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.

Adults' experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes

Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection

Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre

Asthma and MIF: innately Th1 and Th2

Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension.

CCR4 in human allergen-induced late responses in the skin and lung

CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry

CXCR1+CD4+ T cells in human allergic disease.

Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension.

Characterisation of the biological activity of recombinant equine eotaxin in vitro

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.

Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension.

Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models

Diesel exhaust particle exposure in vitro alters monocyte differentiation and function

Diesel exhaust particles override natural injury-limiting pathways in the lung.

Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.

Editorial: RSV: a new box of delights for an old enemy.

Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response.

Endotoxin tolerance induces selective alterations in neutrophil function.

Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability

Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold

Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension

Idiopathic and Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes.

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Incapacitating the immune system in cystic fibrosis

Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I.

Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension.

Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension.

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Management dilemmas in acute pulmonary embolism

Management of acute pulmonary embolism.

Measurement of Granulocyte Pharmacodynamics in Whole Blood by Flow Cytometry

Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

Pathophysiology and Diagnosis of Pulmonary Hypertension Due to Left Heart Disease.

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease

Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy

Physician narratives of illness

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

Potentiation of TLR4 signalling by plasmin activity

Practical and conceptual models of chronic obstructive pulmonary disease.

Practical phenotyping of difficult asthma

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic-pathophysiologic classification.

Pulmonary hypertension in COPD: results from the ASPIRE registry.

Pulmonary hypertension: diagnosis and management

Reducing the toll of inflammatory lung disease.

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists

Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.

Roles of chemokines in the regulation of leucocyte recruitment

Sarcoidosis presenting with chylothorax

Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin

T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.