Search filters

List of works by Yuki Takahashi

Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells.

scientific article published on July 2017

Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector

scientific article published on 3 March 2017

Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS

scientific article

Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells

scientific article published in February 2016

Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

scientific article published on 6 October 2010

Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance

scientific article published on 26 November 2019

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics.

scientific article published on 5 October 2016

Combined encapsulation of a tumor antigen and immune cells using a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity

scientific article published on 13 September 2018

Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy

scientific article published in April 2012

Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice

scientific article

Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver.

scientific article published on 7 August 2015

Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation.

scientific article

Controlling the kinetics of interferon transgene expression for improved gene therapy.

scientific article published on 20 September 2012

Corrigendum: Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion.

scientific article published on 7 January 2016

DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells

scientific article published on 07 July 2020

DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy.

scientific article

DNA nanotechnology-based development of delivery systems for bioactive compounds.

scientific article published on 30 March 2014

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.

scientific article published on 20 July 2016

Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression

scientific article published on September 2007

Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation.

scientific article published on 3 November 2015

Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression.

scientific article published on May 2009

Effects of Localization of Antigen Proteins in Antigen-Loaded Exosomes on Efficiency of Antigen Presentation

scientific article published on 13 May 2019

Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer

scientific article

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

scientific article published on 12 June 2014

Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion

scientific article published on 14 October 2015

Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA.

scientific article published on 10 December 2013

Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure

scientific article published on 08 August 2017

Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide.

scientific article published on 4 October 2017

Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages.

scientific article published on 7 April 2014

Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells

scientific article

Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus

scientific article published on 29 August 2017

Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA.

scientific article

Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes

scientific article published on 24 September 2013

Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA.

scientific article

Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity

scientific article

Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases

scientific article published on July 2005

Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice.

scientific article

Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA.

scientific article published on July 2007

Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan

scientific article published on 21 November 2016

In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase

scientific article published in January 2017

Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids

scientific article published on 3 September 2015

Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice.

scientific article

Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice

scientific article published on 01 January 2004

Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy.

scientific article published on 31 March 2011

Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice

scientific article published on 27 May 2011

Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes

scientific article published on 14 February 2008

Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-β for Cancer Gene Therapy

scientific article published on 5 August 2016

Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-γ gene transfer.

scientific article published on 28 December 2013

Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

scientific article published on 9 February 2015

Moment analysis for kinetics of gene silencing by RNA interference

scientific article published on March 2006

Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice

scientific article

Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold

scientific article published on 30 April 2012

Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells.

scientific article published on 29 July 2015

Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size

scientific article published in January 2017

Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors.

scientific article published in September 2010

Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics.

scientific article published on 7 March 2017

Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids ⬇️

scientific article published on January 21, 2013

Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice

scientific article published on 30 November 2010

Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application

scientific article published on 01 January 2018

Preservation of exosomes at room temperature using lyophilization

scientific article published on 11 October 2018

Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice.

scientific article published on 18 June 2014

Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice

scientific article published on 18 January 2011

Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice.

scientific article

Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors

scientific article

Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution.

scientific article

Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene.

scientific article published on 20 October 2017

Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression

scientific article published in March 2014

Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response.

scientific article

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages.

scientific article published on 17 September 2016

Role of extracellular vesicle surface proteins in the pharmacokinetics of extracellular vesicles

scientific article published on 30 January 2018

Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins

scientific article published on 4 December 2017

Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA.

scientific article published on 2 May 2011

Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells

scientific article published on 10 September 2015

Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha

scientific article published on 16 September 2006

Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy.

scientific article published on 8 December 2016

Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice.

scientific article published on 31 October 2013

Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice

scientific article published on 25 April 2017

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection ⬇️

scientific article published on April 2, 2013

[In vivo siRNA delivery to tumor cells and its application to cancer gene therapy]

scientific article published on 01 October 2007

[Optimization of gene therapy effect by spaciotemporal control of expressed proteins]

scientific article published on 01 November 2010

Paulina is supported by:

About Paulina

Help