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List of works by Mark Merchant

A comprehensive genetic map of the mouse genome.

scientific article

A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo

scientific article

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

scientific article

A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes

scientific article published on August 1999

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

scientific article

FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth

scientific article

HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors.

scientific article

Immuno-PET of the hepatocyte growth factor receptor Met using the 1-armed antibody onartuzumab

scientific article published on 23 August 2012

Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition

scientific article

LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways

scientific article published in December 2001

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

scientific journal article

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

scientific article

MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

scientific article

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

scientific article

Onartuzumab (MetMAb): using nonclinical pharmacokinetic and concentration-effect data to support clinical development.

scientific article

Oncogenic ERBB3 mutations in human cancers

scientific article

PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts.

scientific article

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

scientific article

Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihy

scientific article published on 23 December 2010

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions

scientific article published on 7 February 2012

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice

scientific article published on 01 October 1995

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly

scientific article published in October 2006

Suppressor of fused regulates Gli activity through a dual binding mechanism

scientific article

The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo

scientific article

WW- and SH3-domain interactions with Epstein-Barr virus LMP2A.

scientific article

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

scientific article

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