List of works - Ya-Xiong Tao

A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity

scientific article published on 12 February 2009

A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.

scientific article

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors

scientific article published on 18 June 2013

Biased signaling at neural melanocortin receptors in regulation of energy homeostasis

scientific article published on 19 April 2017

Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.

scientific article

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors

scientific article

Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants

scientific article

Chaperoning G protein-coupled receptors: from cell biology to therapeutics

scientific article

Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis

scientific article published on 21 March 2019

Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7

scientific journal article

Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.

scientific article published on August 2000

Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists

scientific article

Constitutive activity of neural melanocortin receptors

scientific article published on January 2010

Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor

scientific article published on 31 October 2003

Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene

scientific article

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

scientific article published on December 2003

Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor

scientific article published on 01 March 2003

Effects of fasting, temperature, and photoperiod on preproghrelin mRNA expression in Chinese perch

scientific article published on 20 March 2017

Effects of melanocortin-4 receptor agonists and antagonists on expression of genes related to reproduction in spotted scat, Scatophagus argus.

scientific article published on 14 February 2017

Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle

scientific article

Expression of estrogen receptors in female rainbow trout (Oncorhynchus mykiss) during first ovarian development and under dense rearing condition

scientific article

Expression of luteinizing hormone/human chorionic gonadotropin receptor gene in benign prostatic hyperplasia and in prostate carcinoma in humans

scientific article published on 01 January 1997

Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation

scientific article

Feeding a DHA-enriched diet increases skeletal muscle protein synthesis in growing pigs: association with increased skeletal muscle insulin action and local mRNA expression of insulin-like growth factor 1

scientific article published on 25 February 2013

Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors

scientific article published on 11 October 2018

Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.

scientific article published on January 2013

Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects

scientific article published on 19 July 2005

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

scientific article published on 27 February 2009

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation

scientific article

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity

scientific article published on 19 June 2003

Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.

scientific article

Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects

scientific article published on 15 October 2007

Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations ⬇️

scientific article published on June 30, 2011

Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.

scientific article

Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation

scientific article

Functions of the DRY motif and intracellular loop 2 of human melanocortin 3 receptor

scientific article published on 16 September 2014

Functions of the third intracellular loop of the human melanocortin-3 receptor

scientific article published on 01 January 2013

Functions of transmembrane domain 3 of human melanocortin-4 receptor

scientific article

G Protein-Coupled Receptors as Regulators of Energy Homeostasis

scientific article published on January 1, 2013

G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus.

scientific article published on January 2014

G protein-coupled receptors. Preface

scientific article published on 07 October 2009

G protein‐coupled receptors. Preface

scientific article published on 07 October 2009

GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1/2 signal pathway.

scientific article published on 11 June 2016

Gene structure and expression of leptin in Chinese perch

scientific article published on 26 September 2013

Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling

scientific article

Ghrelin Receptor Mutations and Human Obesity

scientific article

Human intermediate trophoblasts express chorionic gonadotropin/luteinizing hormone receptor gene

scientific article published on 01 October 1995

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

scientific article

Hypothalamus-pituitary-gonad axis of rainbow trout (Oncorhynchus mykiss) during early ovarian development and under dense rearing condition

scientific article published on 8 July 2016

Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population

scientific article published on August 2006

Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds

scientific article

Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.

scientific article

Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis

scientific article

Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.

scientific article

Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.

scientific article

Leptin expression in mandarin fish Siniperca chuatsi (Basilewsky): Regulation by postprandial and short-term fasting treatment

scientific article

Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology

scientific article published on 01 August 2018

Modulation of interferon secretion by concanavalin A and interleukin-2 in first trimester placental explants in vitro

scientific article published on 01 August 1993

Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism

article

Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor

scientific article

Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor

scientific article published on January 2008

Molecular cloning and tissue expression of uncoupling protein 1, 2 and 3 genes in Chinese perch (Siniperca chuatsi).

scientific article published on 28 March 2015

Molecular cloning, expression and single nucleotide polymorphisms of protein phosphatase 1 (PP1) in mandarin fish (Siniperca chuatsi).

scientific article published on 11 August 2015

Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella).

scientific article published on 21 November 2016

Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus

scientific article published on 11 April 2016

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.

scientific article

Mutations in melanocortin-4 receptor and human obesity.

scientific article published on 07 October 2009

Novel expression of luteinizing hormone/chorionic gonadotropin receptor gene in rat prostates

scientific article published on 01 April 1995

Obestatin partially suppresses ghrelin stimulation of appetite in "high-responders" grass carp, Ctenopharyngodon idellus

scientific article published on 01 March 2015

Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor

scientific article published on 07 January 2010

Pharmacologic analyses of four chicken melanocortin-4 receptor mutations

scientific article published on 2 July 2015

Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs

scientific article published on 18 December 2007

Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity.

scientific article published on 8 March 2017

Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.

scientific article

Pharmacology and therapeutics of constitutively active receptors. Preface

scientific article published on 01 January 2014

Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor

scientific article published on 01 November 2018

Pharmacoperone drugs: targeting misfolded proteins causing lysosomal storage-, ion channels-, and G protein-coupled receptors-associated conformational disorders

scientific article published on 11 June 2018

Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases

scientific article published in April 2018

Physiology and therapeutics of the free fatty acid receptor GPR40.

scientific article published on January 2014

Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor

scientific article

Preface

Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio

scientific article published on 11 October 2013

Regulation of prostate cancer by hormone-responsive G protein-coupled receptors

scientific article published on 15 June 2018

Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.

scientific article published on 8 May 2015

Targeting GPR119 for the potential treatment of type 2 diabetes mellitus.

scientific article published on January 2014

The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

scientific article

The presence of luteinizing hormone/human chorionic gonadotropin receptors in lactating rat mammary glands

scientific article published on 01 January 1997

The urinary bladder of a woman is a novel site of luteinizing hormone-human chorionic gonadotropin receptor gene expression

scientific article published on 01 October 1998

Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.

scientific article published on 24 April 2015

Transcriptome analysis of food habit transition from carnivory to herbivory in a typical vertebrate herbivore, grass carp Ctenopharyngodon idella

scientific article

Transcriptome analysis of grass carp (Ctenopharyngodon idella) fed with animal and plant diets

scientific article published on 14 August 2015

List of works by Ya-Xiong Tao

A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity

A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors

Biased signaling at neural melanocortin receptors in regulation of energy homeostasis

Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors

Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants

Chaperoning G protein-coupled receptors: from cell biology to therapeutics

Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis

Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7

Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.

Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists

Constitutive activity of neural melanocortin receptors

Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor

Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor

Effects of fasting, temperature, and photoperiod on preproghrelin mRNA expression in Chinese perch

Effects of melanocortin-4 receptor agonists and antagonists on expression of genes related to reproduction in spotted scat, Scatophagus argus.

Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle

Expression of estrogen receptors in female rainbow trout (Oncorhynchus mykiss) during first ovarian development and under dense rearing condition

Expression of luteinizing hormone/human chorionic gonadotropin receptor gene in benign prostatic hyperplasia and in prostate carcinoma in humans

Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation

Feeding a DHA-enriched diet increases skeletal muscle protein synthesis in growing pigs: association with increased skeletal muscle insulin action and local mRNA expression of insulin-like growth factor 1

Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors

Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.

Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity

Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.

Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects

Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations ⬇️

Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.

Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation

Functions of the DRY motif and intracellular loop 2 of human melanocortin 3 receptor

Functions of the third intracellular loop of the human melanocortin-3 receptor

Functions of transmembrane domain 3 of human melanocortin-4 receptor

G Protein-Coupled Receptors as Regulators of Energy Homeostasis

G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus.

G protein-coupled receptors. Preface

G protein‐coupled receptors. Preface

GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1/2 signal pathway.

Gene structure and expression of leptin in Chinese perch

Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling

Ghrelin Receptor Mutations and Human Obesity

Human intermediate trophoblasts express chorionic gonadotropin/luteinizing hormone receptor gene

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

Hypothalamus-pituitary-gonad axis of rainbow trout (Oncorhynchus mykiss) during early ovarian development and under dense rearing condition

Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population

Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds

Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.

Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis

Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.

Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.

Leptin expression in mandarin fish Siniperca chuatsi (Basilewsky): Regulation by postprandial and short-term fasting treatment

Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology

Modulation of interferon secretion by concanavalin A and interleukin-2 in first trimester placental explants in vitro

Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism

Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor

Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor

Molecular cloning and tissue expression of uncoupling protein 1, 2 and 3 genes in Chinese perch (Siniperca chuatsi).

Molecular cloning, expression and single nucleotide polymorphisms of protein phosphatase 1 (PP1) in mandarin fish (Siniperca chuatsi).

Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella).

Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.

Mutations in melanocortin-4 receptor and human obesity.

Novel expression of luteinizing hormone/chorionic gonadotropin receptor gene in rat prostates

Obestatin partially suppresses ghrelin stimulation of appetite in "high-responders" grass carp, Ctenopharyngodon idellus

Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor

Pharmacologic analyses of four chicken melanocortin-4 receptor mutations

Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs

Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity.

Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.

Pharmacology and therapeutics of constitutively active receptors. Preface

Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor

Pharmacoperone drugs: targeting misfolded proteins causing lysosomal storage-, ion channels-, and G protein-coupled receptors-associated conformational disorders

Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases

Physiology and therapeutics of the free fatty acid receptor GPR40.