List of works - Brian Harvey

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

scientific article

A brain-behaviour initiative for South Africa: the time is right

scientific article

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward

scientific article published on 01 February 2019

A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression.

scientific article published on 2 October 2010

A novel hypothesis for the psycho-modulating effects of lithium: the role of essential fatty acids, eicosanoids and sub-cellular second messengers

scientific article published on May 1990

A psycho-behavioral perspective on modelling obsessive-compulsive disorder (OCD) in animals: The role of context

scientific article published on 23 May 2017

A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia.

scientific article published on 2 July 2014

Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders

scientific article published on 27 March 2019

Absence of an effect of the lithium-induced increase in cyclic GMP on the cyclic GMP-stimulated phosphodiesterase (PDE II). Evidence for cyclic AMP-specific hydrolysis

scientific article published on 01 October 1993

Acid-dependent dismutation of nitrogen oxides may be a critical source of nitric oxide in human macrophages

scientific article published on 01 May 2000

Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs

scientific article published on 01 July 2018

An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats

scientific article

Animal models of major depressive disorder and the implications for drug discovery and development

scientific article published on 22 February 2019

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.

scientific article published in September 2010

Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies.

scientific article published on 7 September 2007

Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study

scientific article

Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties

scientific article published in November 2014

Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase.

scientific article

Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology

scientific article published in November 2008

Central effects of the preservative, methylparaben. In vivo activation of cAMP-specific phosphodiesterase and reduction of cortical cAMP.

scientific article published in September 1992

Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study

scientific article published on 2 March 2016

Chronic inositol increases striatal D(2) receptors but does not modify dexamphetamine-induced motor behavior. Relevance to obsessive-compulsive disorder

scientific article

Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats.

scientific article published on 23 February 2012

Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder

scientific article published on 6 March 2006

Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment.

scientific article

Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse

scientific article

Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression.

scientific article published in August 2012

Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder

scientific article

Depression Symptoms Facilitated Fibrinolytic Dysregulation and Future Coronary Artery Disease Risk in a Black Male Cohort: The Sympathetic Activity and Ambulatory Blood Pressure in Africans Study

scientific article published on 13 July 2016

Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study

scientific article published on 6 September 2012

Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study

scientific article

Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function

scientific article published on 28 July 2011

Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.

scientific article published on 4 May 2012

Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats

scientific article published on 24 May 2011

Distinct intrinsic functional brain network abnormalities in methamphetamine-dependent patients with and without a history of psychosis

scientific article published on 5 December 2016

Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram

scientific article published on 28 November 2005

Early suppression of striatal cyclic GMP may predetermine the induction and severity of chronic haloperidol-induced vacous chewing movements

scientific article

Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

scientific article published in Scientific Reports

Effect of Chronic N-Acetyl Cysteine Administration on Oxidative Status in the Presence and Absence of Induced Oxidative Stress in Rat Striatum

scientific article published on 31 August 2007

Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells

scientific article published on June 2004

Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial

scientific article published on 11 October 2018

Endocrine, cognitive and hippocampal/cortical 5HT 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats

scientific article published in September 2003

Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression

scientific article published on 01 October 2019

Evidence that lithium induces a glutamatergic: nitric oxide-mediated response in rat brain

scientific article

Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder

scientific article published on 6 May 2016

Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine

scientific article published on 30 August 2016

Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies

scientific article

Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study

scientific article published on March 2012

Fluoxetine decreases stereotypic behavior in primates

scientific article

Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat.

scientific article

Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors

scientific article published on 22 July 2006

Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression

scientific article

Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism

scientific article published on 29 January 2010

Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma

scientific article published in July 2005

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

scientific article published on 20 October 2010

Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?

scientific article published on 28 June 2018

Late-life effects of chronic methamphetamine exposure during puberty on behaviour and corticostriatal mono-amines in social isolation-reared rats.

scientific article published on 24 January 2014

Lithium modulation of cortical cyclic nucleotides: evidence for the Yin-Yang hypothesis

scientific article published on January 1990

Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity

scientific article published on January 2003

Long-lasting effects of fluoxetine and/or exercise augmentation on bio-behavioural markers of depression in pre-pubertal stress sensitive rats.

scientific article

Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.

scientific article published on 7 November 2016

Metabolic and Glutathione Redox Markers Associated with Brain-Derived Neurotrophic Factor in Depressed African Men and Women: Evidence for Counterregulation? ⬇️

scientific article published on December 4, 2012

Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models

scientific article published on June 25, 2011

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

scientific article published on 25 July 2018

Methylene blue and its analogues as antidepressant compounds.

scientific article published on 31 July 2017

N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats.

scientific article published on 3 September 2013

N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges.

scientific article

NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus

scientific article published in May 2002

Neurobiology of antidepressant withdrawal: implications for the longitudinal outcome of depression

scientific article published on November 2003

Neurochemical differences in two rat strains exposed to social isolation rearing.

scientific article published on 01 October 2012

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development.

scientific article published on 02 April 2015

Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries

scientific article published on 06 May 2014

Neuroscience in Africa

scientific article published in September 2006

New insights on the antidepressant discontinuation syndrome.

scientific article

Obsessive-compulsive disorder: Insights from animal models

scientific article published on 7 May 2016

Of mice and marbles: Novel perspectives on burying behavior as a screening test for psychiatric illness

scientific article

Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response

scientific article

Ozone modulates the effects of imipramine on immobility in the forced swim test, and nonspecific parameters of hippocampal oxidative stress in the rat.

scientific article published on 9 May 2010

Pathological Consequences of Drug Abuse: Implication of Redox Imbalance

scientific article published on 22 September 2019

Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges

scientific article published on 6 December 2017

Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006 - 2011.

scientific article published on 5 January 2015

Re: Less is more.

scientific article

Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to escitalopram treatment and basal serotonin transporter (SERT) density

scientific article

Role of aging and striatal nitric oxide synthase activity in an animal model of tardive dyskinesia

scientific article published in August 2003

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

scientific article published on 10 August 2010

Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma?

scientific article

Simulated systemic recurrent Mycoplasma infection in rats induces recurrent sickness responses without residual impairment in spatial learning and memory

scientific article published on 18 October 2011

Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol

scientific article

Social behavior in deer mice as a novel interactive paradigm of relevance for obsessive-compulsive disorder (OCD).

scientific article published on 28 January 2016

Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.

scientific article published on 9 March 2012

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine.

scientific article published on 25 December 2012

Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin.

scientific article published on 21 February 2019

Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder

scientific article published on 29 August 2007

Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement

scientific article

Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

scientific article

Studies into the anxiolytic actions of agomelatine in social isolation reared rats: Role of corticosterone and sex.

scientific article published in October 2017

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

scientific article published on 18 August 2015

The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

scientific article published on 13 March 2019

The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats.

scientific article

The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-D-aspartate and D1 receptor binding in rats

scientific article published in January 2010

The impact of HIV/AIDS on compliance with antidepressant treatment in major depressive disorder: A prospective study in a South African private healthcare cohort

scientific article

The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase

scientific article published on 23 October 2013

The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression

scientific article published on 18 November 2015

The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

scientific article

The nature of relapse in schizophrenia ⬇️

scientific article published on February 8, 2013

The stimulatory effect of chronic lithium treatment on basal thyrotropin secretion in rats: In vivo antagonism by methylparaben

scientific article published on 01 October 1993

The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time

scientific article

The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat.

scientific article published on 30 September 2016

The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol.

scientific article published on 2 July 2016

Therapeutic Potential of Selectively Targeting the α2C-Adrenoceptor in Cognition, Depression, and Schizophrenia-New Developments and Future Perspective

scientific article published on 14 August 2017

Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression

scientific article

Withdrawal-associated changes in peripheral nitrogen oxides and striatal cyclic GMP after chronic haloperidol treatment

scientific article published in June 2000

List of works by Brian Harvey

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

A brain-behaviour initiative for South Africa: the time is right

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward

A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression.

A novel hypothesis for the psycho-modulating effects of lithium: the role of essential fatty acids, eicosanoids and sub-cellular second messengers

A psycho-behavioral perspective on modelling obsessive-compulsive disorder (OCD) in animals: The role of context

A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia.

Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders

Absence of an effect of the lithium-induced increase in cyclic GMP on the cyclic GMP-stimulated phosphodiesterase (PDE II). Evidence for cyclic AMP-specific hydrolysis

Acid-dependent dismutation of nitrogen oxides may be a critical source of nitric oxide in human macrophages

Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs

An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats

Animal models of major depressive disorder and the implications for drug discovery and development

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.

Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies.

Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study

Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties

Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase.

Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology

Central effects of the preservative, methylparaben. In vivo activation of cAMP-specific phosphodiesterase and reduction of cortical cAMP.

Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study

Chronic inositol increases striatal D(2) receptors but does not modify dexamphetamine-induced motor behavior. Relevance to obsessive-compulsive disorder

Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats.

Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder

Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment.

Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse

Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression.

Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder

Depression Symptoms Facilitated Fibrinolytic Dysregulation and Future Coronary Artery Disease Risk in a Black Male Cohort: The Sympathetic Activity and Ambulatory Blood Pressure in Africans Study

Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study

Depressive Symptoms and 24-Hour Ambulatory Blood Pressure in Africans: The SABPA Study

Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function

Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.

Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats

Distinct intrinsic functional brain network abnormalities in methamphetamine-dependent patients with and without a history of psychosis

Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram

Early suppression of striatal cyclic GMP may predetermine the induction and severity of chronic haloperidol-induced vacous chewing movements

Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

Effect of Chronic N-Acetyl Cysteine Administration on Oxidative Status in the Presence and Absence of Induced Oxidative Stress in Rat Striatum

Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells

Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial

Endocrine, cognitive and hippocampal/cortical 5HT 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats

Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression

Evidence that lithium induces a glutamatergic: nitric oxide-mediated response in rat brain

Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder

Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine

Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies

Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study

Fluoxetine decreases stereotypic behavior in primates

Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat.

Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors

Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression

Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism

Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?

Late-life effects of chronic methamphetamine exposure during puberty on behaviour and corticostriatal mono-amines in social isolation-reared rats.

Lithium modulation of cortical cyclic nucleotides: evidence for the Yin-Yang hypothesis

Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity

Long-lasting effects of fluoxetine and/or exercise augmentation on bio-behavioural markers of depression in pre-pubertal stress sensitive rats.

Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.

Metabolic and Glutathione Redox Markers Associated with Brain-Derived Neurotrophic Factor in Depressed African Men and Women: Evidence for Counterregulation? ⬇️

Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

Methylene blue and its analogues as antidepressant compounds.

N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats.

N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges.

NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus

Neurobiology of antidepressant withdrawal: implications for the longitudinal outcome of depression

Neurochemical differences in two rat strains exposed to social isolation rearing.

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development.

Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries

Neuroscience in Africa

New insights on the antidepressant discontinuation syndrome.

Obsessive-compulsive disorder: Insights from animal models

Of mice and marbles: Novel perspectives on burying behavior as a screening test for psychiatric illness

Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response

Ozone modulates the effects of imipramine on immobility in the forced swim test, and nonspecific parameters of hippocampal oxidative stress in the rat.

Pathological Consequences of Drug Abuse: Implication of Redox Imbalance