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List of works by Albert D. Windhorst

(11) C-labeled and (18) F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain.

scientific article published on March 2013

(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

scientific article published on October 2003

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

scientific article published on 28 May 2014

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

scientific article

3'-Sulfonylesters of 2,5'-anhydro-1-(2-deoxy-beta-d-threo-pentofuranosyl)thymine as precursors for the synthesis of [(18)F]FLT: syntheses and radiofluorination trials

scientific article published in May 2008

A novel partial volume correction method for accurate quantification of [F] flortaucipir in the hippocampus

A universal procedure for the [¹⁸F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity.

scientific article

Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography

scientific article published on 12 July 2011

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

scientific article

Amyloid and its association with default network integrity in Alzheimer's disease

scientific article published on 14 December 2012

Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement

scientific article published on 3 May 2012

Assessment of simplified methods to measure 18F-FLT uptake changes in EGFR-mutated non-small cell lung cancer patients undergoing EGFR tyrosine kinase inhibitor treatment.

scientific article

Bengt Långström--a pioneer in carbon-11 radiochemistry

scientific article published in March 2015

Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients

scientific article

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

scientific article published on 18 May 2016

Blood-brain barrier P-glycoprotein function in Alzheimer's disease

scientific article published on 26 November 2011

Brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit in rat and mouse, determined with ex vivo [125I]iodophenpropit binding.

scientific article published in December 1996

Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages.

scientific article published on January 2010

Characterization of the binding site of the histamine H(3) receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide.

scientific article published in May 2000

Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images

scientific article published on 4 June 2014

Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum

scientific article published on 27 August 2008

Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET.

scientific article published on 21 January 2009

Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status.

scientific article published on 7 November 2012

Development of [18F]afatinib as new TKI-PET tracer for EGFR positive tumors

scientific article

Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies

scientific article published in July 2005

Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment

scientific article published in December 2009

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia

scientific article published on 19 December 2012

EANM guideline for the preparation of an Investigational Medicinal Product Dossier (IMPD)

scientific article published on 01 November 2014

Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.

scientific article published on 24 October 2011

Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC.

scientific article published on 9 February 2016

Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes

scientific article

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

scientific article published in January 2005

Evaluation of [ 18 F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H 3 receptor

scientific article published on 01 September 1999

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

scientific article published in August 2009

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

scientific article published on March 2013

Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies

scientific article published on 2 April 2009

Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

scientific article published on 7 June 2006

Feasibility and repeatability of PET with the hypoxia tracer [(18)F]HX4 in oesophageal and pancreatic cancer.

scientific article

First evaluation of [11C]R116301 as an in vivo tracer of NK1 receptors in man

scientific article published on 31 March 2009

First in human evaluation of [F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters

scientific article published on 14 September 2013

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

scientific article

Imaging of TKI-target interactions for personalized cancer therapy

scientific article published on 12 December 2012

Imaging of fibrogenesis in patients with idiopathic pulmonary fibrosis with cis-4-[(18)F]-Fluoro-L: -proline PET.

scientific article published on 30 July 2008

Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies

scientific article published on 4 January 2016

Impact of molecular imaging on the diagnostic process in a memory clinic

scientific article

Improved and semi-automated GMP-compliant radiosynthesis of [11C]docetaxel

scientific article published on 10 March 2008

Improved synthesis and application of [(11) C]benzyl iodide in positron emission tomography radiotracer production

scientific article

In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans.

scientific article published on 5 May 2015

In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18F]HX4 and [18F]FDG-PET/CT imaging

scientific article published on 14 October 2014

In vivo quantification of striatal dopamine D2 receptor occupancy by JNJ-37822681 using [11C]raclopride and positron emission tomography

scientific article published on 30 January 2012

Insights into imaging in drug discovery and development

article

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

scientific article published on 18 April 2014

Longitudinal amyloid imaging using 11C-PiB: methodologic considerations

scientific article published on 12 August 2013

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET.

scientific article published on 23 March 2012

Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

scientific article published on 4 June 2008

Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study

scientific article published on 26 July 2012

Microglial activation in healthy aging

Model selection criteria for dynamic brain PET studies

scientific article published on 6 December 2017

Molecular markers of Alzheimer's Disease pathology and their relationship with default mode network integrity

scholarly article by Sofie Adriaanse et al published July 2011 in Alzheimer's and Dementia

Monitoring response to radiotherapy in human squamous cell cancer bearing nude mice: comparison of 2'-deoxy-2'-[18F]fluoro-D-glucose (FDG) and 3'-[18F]fluoro-3'-deoxythymidine (FLT).

scientific article published on November 2007

Multiparametric Analysis of the Relationship Between Tumor Hypoxia and Perfusion with ¹⁸F-Fluoroazomycin Arabinoside and ¹⁵O-H₂O PET.

scientific article published on 10 December 2015

No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds

scientific article

Novel Thienopyrimidine-Based PET Tracers for P2Y<sub>12</sub> Receptor Imaging in the Brain

scientific article published on 10 November 2021

Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines.

scientific article published on 13 January 2018

Optimizing an online SPE–HPLC method for analysis of (R)-[11C]1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide [(R)-[11C]PK11195] and its metabolites in humans

scientific article published on 01 April 2005

P-glycoprotein function at the blood-brain barrier: effects of age and gender

scientific article

PET imaging of hypoxia using [18F]HX4: a phase I trial

scientific article

PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET.

scientific article published on 02 July 2012

Parametric Binding Images of the TSPO Ligand 18F-DPA-714.

scientific article published on 3 June 2016

Parametric Methods for Dynamic 11C-Phenytoin PET Studies

scientific article

Parametric methods for [18F]flortaucipir PET

scientific article published on 20 December 2018

Parametric methods for quantification of 18F-FAZA kinetics in non-small cell lung cancer patients

scientific article published on 16 October 2014

Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept

scientific article

Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites

scientific article published in November 2008

Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients.

scientific article

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

scientific article

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands.

scientific article

Preclinical Targeted α- and β--Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies

scientific article published on 21 April 2020

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging

scientific article

Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors

scientific article published on 30 September 2014

Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis

scientific article

Quantification of 11C-Laniquidar Kinetics in the Brain

scientific article published on 20 August 2015

Quantification of 18F-fluorocholine kinetics in patients with prostate cancer.

scientific article

Quantification of Dynamic 11C-Phenytoin PET Studies

scientific article published in July 2015

Quantification of O-(2-[F]fluoroethyl)-L-tyrosine kinetics in glioma

Quantification of Tau Load Using [(18)F]AV1451 PET.

scientific article published on 3 April 2017

Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium

scientific article

Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients

scientific article published on 4 February 2015

Quantification of [18F]florbetapir: A test–retest tracer kinetic modelling study

scientific article published on 13 June 2018

Quantification of dopamine transporter binding using [18F]FP-beta-CIT and positron emission tomography

scientific article

Quantification of the neurokinin 1 receptor ligand [11C]R116301

scientific article published on 01 October 2011

Quantification of the novel N-methyl-d-aspartate receptor ligand [11C]GMOM in man

scientific article published on 05 October 2015

Quantitative and Simplified Analysis of 11C-Erlotinib Studies

scientific article published on 4 February 2016

Radiation dose of the P-glycoprotein tracer 11C-laniquidar

scientific article published on 3 October 2013

Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier.

scientific article

Radiosynthesis and biodistribution of 123I-labeled antagonists of the histamine H3 receptor as potential SPECT ligands

scientific article published on 01 August 1999

Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand

scientific article published in August 2006

Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor

scientific article

Radiosynthesis of 1-iodo-2-[11 C]methylpropane and 2-methyl-1-[11 C]propanol and its application for alkylation reactions and C-C bond formation.

scientific article published on 29 July 2017

Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs.

scientific article published in January 2012

Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding

scientific article published on 18 August 2009

Reproducibility and repeatability of semi-quantitative 18F-fluorodihydrotestosterone (FDHT) uptake metrics in castration-resistant prostate cancer metastases: a prospective multi-center study.

scientific article published on 6 April 2018

Reproducibility of quantitative (R)-[11C]verapamil studies

scientific article published on 17 January 2012

Residual solvent analysis by gas chromatography in radiopharmaceutical formulations containing up to 12% ethanol

scientific article published on 01 October 2006

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

scientific article published on 14 May 2011

Structure-activity relationships of N-substituted 4-(trifluoromethoxy)benzamidines with affinity for GluN2B-containing NMDA receptors.

scientific article

Subchronic treatment with phencyclidine in adolescence leads to impaired exploratory behavior in adult rats without altering social interaction or N-methyl-D-aspartate receptor binding levels

scientific article

Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier

scientific article published on 4 June 2015

Synthesis and biodistribution of [(11)C]R116301, a promising PET ligand for central NK(1) receptors

scientific article published in March 2005

Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist

scientific article published on 6 March 2006

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation

scientific article published in June 2014

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

scientific article published on 5 January 2012

Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors

scientific article published on 10 May 2014

Synthesis of 2-(1,1-dicyanopropen-2-yl)-6-(2-[18F]-fluoroethyl)-methylamino-naphthalene ([18F]FDDNP).

scientific article published on 30 October 2007

Synthesis of [3-N-(11) C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [(11) C]methyl iodide.

scientific article

Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography

scientific article published on 24 December 2014

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

scientific article published on 10 January 2013

Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease

scientific article published on 22 April 2009

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors

scientific article

The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects

scientific article published on 5 August 2014

The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease

scientific article published on 11 March 2014

Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C]docetaxel and positron emission tomography.

scientific article published on 25 April 2013

Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[¹⁸F]fluoro-5-deoxyribose as a novel tracer

scientific article published on 27 March 2013

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

scientific article published in Nature Communications

Widespread and prolonged increase in (R)-(11)C-PK11195 binding after traumatic brain injury

scientific article (publication date: August 2011)

[(18)F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models.

scientific article published on 24 February 2015

[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

scientific article

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

scientific article published on 2 July 2012

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

scientific article

[¹¹C]Sorafenib: radiosynthesis and preclinical evaluation in tumor-bearing mice of a new TKI-PET tracer

scientific article published on 20 March 2013

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