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List of works by Markus H Heim

25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end ⬇️

scientific article published on June 7, 2013

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.

scientific article

A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients

scientific article

A new survival trick of hepatitis C virus: blocking the activation of interferon regulatory factor-3.

scientific article published on December 2003

A systematic review and meta-analysis of HCV clearance

scientific article published on 6 March 2017

Acetylation of serotonin in the rabbit pineal gland: an N-acetyltransferase with properties distinct from NAT1 and NAT2 is responsible

scientific article published on October 1991

Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.

scientific article published in August 2007

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

scientific article

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.

scientific article published on 21 January 2015

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.

scientific article published on 18 November 2013

Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma

scientific article published on 6 August 2012

Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3.

scientific article

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

scientific article published on 23 March 2015

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

scientific article

Clinical course of infection and viral tissue tropism of hepatitis C virus-like nonprimate hepaciviruses in horses

scientific article published on 5 January 2015

Clinical significance of the CCR5delta32 allele in hepatitis C

scientific article

Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

scientific article

Constitutive Notch2 signaling induces hepatic tumors in mice

scientific article published on 14 March 2013

Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study

scientific article

Contrary to HIV, hepatitis C virus is not associated with erythrocytes in vivo

scientific article published on January 2005

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway

scientific article published on March 1995

Correction: S-Adenosyl-Methionine and Betaine Improve Early Virological Response in Chronic Hepatitis C Patients with Previous Nonresponse.

scientific article published on 17 November 2010

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

scientific article published in October 2016

Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C.

scientific article published on 18 October 2011

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

scientific article published in October 1991

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

scientific article

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha

scientific article published on 01 March 2000

Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening

scientific article published on 22 August 2018

Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

scientific article published on 12 January 2012

Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia

scientific article published on 21 July 2013

Effect of Hepatitis B virus on Steatosis in Hepatitis C virus co-infected subjects: a multi-center study and systematic review

scientific article published on 13 March 2018

Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C.

scientific article published in December 2010

Effect of corticosteroids during ongoing drug exposure in pantoprazole-induced interstitial nephritis

scientific article published on 12 January 2010

Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection

scientific article published on 16 September 2011

Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon-α and ribavirin in chronic hepatitis C virus patients

scientific article published on 29 August 2013

Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha

scientific article published on 5 September 2013

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

scientific article published on 29 December 2021

Erratum: Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

scientific article published in Nature Communications

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.

scientific article

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

scientific article published on 10 December 2019

Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice

scientific article published in May 2003

Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results

scientific article published on 4 April 2013

From Molecuar to Natural Medicine

scientific article

Fulminant Liver Failure Associated with Clarithromycin

scholarly article by Andreas Tietz et al published January 2003 in Annals of Pharmacotherapy

Fulminant liver failure associated with clarithromycin

scientific article

Gene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinoma

scientific article published on 05 February 2016

Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model

scientific article

Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development

scientific article

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.

scientific article published on 2 March 2018

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

scientific article

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection

scientific article

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.

scientific article published on 6 June 2009

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

scientific article published in The Lancet

Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease

scientific article

Growth of Epithelial Organoids in a Defined Hydrogel

scientific article published on 10 September 2018

Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer

article

HCV Innate Immune Responses ⬇️

scientific article published on November 30, 2009

HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models

scientific article

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.

scientific article published on March 2013

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

scientific article published on 7 October 2016

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation

scientific article published on 18 July 2016

Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

scientific article

Hepatitis B Virus Does Not Interfere with Innate Immune Responses in the Human Liver

scientific article published on 2 February 2018

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection.

scientific article published on 9 February 2017

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis.

scientific article published on 04 May 2016

Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation

scientific article (publication date: 2010)

Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress

scientific article published in August 2012

Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1.

scientific article published on 6 November 2013

Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.

scientific article published on January 2004

Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair

scientific article published on March 2010

Hepatitis with fibrin-ring granulomas

scientific article

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors

scientific article published on 06 May 2019

Hepatozelluläres Karzinom

scientific article published on 01 April 2011

Host - hepatitis C viral interactions: The role of genetics

scientific article published on October 2016

Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection

scientific article published on 14 July 2008

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression

scientific journal article

I06 Host-virus interactions in acute and chronic hepatitis C

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies

scientific article

IL-17 reduces TNF-induced Rantes and VCAM-1 expression

scientific article published on 01 August 2005

IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes

scientific article published on 16 December 2011

Impact of common risk factors of fibrosis progression in chronic hepatitis C.

scientific article published on 11 September 2014

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

In vivo analysis at the cellular level reveals similar steatosis induction in both hepatitis C virus genotype 1 and 3 infections

scientific article published on 31 October 2017

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice

scientific article

Inhibition of Alpha Interferon Signaling by Hepatitis B Virus

scientific article (publication date: 2007)

Innate and adaptive immune responses in HCV infections

scientific article

Innate immunity and HCV.

scientific article published on 11 October 2012

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

scientific article published on 04 May 2022

Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells

scientific article published on 06 November 2020

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

scientific article published on 12 August 2021

Interferon signaling and treatment outcome in chronic hepatitis C

scientific article (publication date: 13 May 2008)

Interferon signaling in the liver during hepatitis C virus infection.

scientific article published on 28 June 2012

Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response

scientific article

Interferon-induced gene expression in chronic hepatitis C

article

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

scientific article published on 25 November 2010

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

scientific article

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo

scientific article published on April 2011

Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C.

scientific article published on 4 June 2012

Interferons and hepatitis C virus ⬇️

scientific article published on 09 May 2012

Interleukin 6 is important for survival after partial hepatectomy in mice

scientific article published in September 2003

Is tumor biopsy necessary?

scientific article published on October 2011

Isolate-dependent use of claudins for cell entry by hepatitis C virus

scientific article published on January 2014

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

scientific article published on 17 December 2019

Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells

scientific article published on 29 August 2019

Liver damage and senescence increases in patients developing hepatocellular carcinoma

scientific article published on 3 January 2017

Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell response

scientific article published on September 2000

Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

scientific article

MRI of Hepatic Adenomatosis: Initial Observations with Gadoxetic Acid Contrast Agent in Three Patients

scientific article published on 01 May 2008

Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients

scientific article published on 17 April 2019

Mechano-modulatory synthetic niches for liver organoid derivation

scientific article published on 10 July 2020

MicroRNAs 103 and 107 regulate insulin sensitivity

scientific article (publication date: 8 June 2011)

New insights into HDV-induced innate immunity: MDA5 senses HDV replication

scientific article published on 11 April 2018

Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as a causal factor

scientific article published on 28 April 2014

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice

article

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

scientific article

Nucleotide sequence of rabbit NAT1 encoding monomorphic arylamine N-acetyltransferase

scientific article published on September 1990

Nucleotide sequence of rabbit NAT2 encoding polymorphic liver arylamine N-acetyltransferase (NAT).

scientific article published on September 1990

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

scientific article published on 01 July 2018

Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation

scientific article published on 24 February 2014

Pegylated interferon-alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation.

scientific article published on 3 December 2008

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

scientific article published on 13 December 2021

Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.

scientific article published on 26 October 2017

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication

scientific article published on October 2008

Polymerase chain reaction and its potential as a pharmacokinetic tool

scientific article published on November 1, 1992

Predicting debrisoquine phenotype

scientific article published in February 1991

Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection

scientific article published on 29 January 2010

Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.

scientific article published on 29 July 2013

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient

scientific article published on 19 January 2016

Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease

scientific article published on 18 December 2013

RIG-I: an essential regulator of virus-induced interferon production

scientific article

Rapid and strong antiviral activity of the non-nucleosidic NS5B polymerase inhibitor BI 207127 in combination with peginterferon alfa 2a and ribavirin

scientific article published on 10 March 2012

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

scientific article published on 23 December 2014

Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection

scientific article published in December 2013

S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro

scientific article published on April 2006

S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse

scientific article

SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules

scientific article published on 3 December 2013

SOCS1 is an inducible negative regulator of IFN lambda induced gene expression in vivo

scientific article published on 12 September 2017

Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist

article

Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy

scientific article

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

scientific article published on 25 April 2014

Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls

scientific article

Specific activation of AP-1 but not Stat3 in regenerating liver in mice

scientific article published on November 1997

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

scientific article

Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization

scientific article published on 16 November 2021

Symptomatic Hepatocellular Liver Injury With Hyperbilirubinemia in Two Patients Treated With Rivaroxaban

scientific article published on 01 October 2014

The Angiotensin II Receptor Antagonist Candesartan Is Not Effective in Reducing Portal Hypertension in Patients with Cirrhosis

scientific article published on 29 June 2007

The IFN-λ Pony Express

scientific article published on 01 May 2019

The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus

scientific article published on January 1996

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

scientific article published on 26 September 2016

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

scientific article published on 18 April 2016

The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota

scientific article published on May 2014

The protein histidine phosphatase LHPP is a tumour suppressor.

scientific article published on 21 March 2018

Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver

scientific article

Treatment of hepatitis C in HCV mono-infected and in HIV-HCV co-infected patients: an open-labelled comparison study

scientific article published on 19 July 2010

Ultrasound surveillance for hepatocellular carcinoma: real-life performance in a hepatology outpatient clinic

scientific article published on 20 November 2015

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma

scientific article published on 22 August 2019

Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.

scientific article

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

scientific article published on 12 January 2011

Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.

scientific article

Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α.

scientific article published on 12 May 2014

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

scientific article published on 14 July 2015

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

scientific article published in December 2017

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

scientific article

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