List of works - Markus Sperandio

A Novel ex vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks

article

A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.

scientific article published on 28 July 2009

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase

scientific article

Analysis of leukocyte rolling in vivo and in vitro

scientific article published in January 2006

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

scientific article

Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin

scientific article

Blood flow resistance during hemodilution: effect of plasma composition

scientific article published in January 1998

CEP: a new β2integrin ligand in inflamed tissue

scientific article published on 01 July 2018

Calcium signalling and related ion channels in neutrophil recruitment and function

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.

scientific article published on 18 April 2018

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis

article

Circadian Clock and Hypoxia

scientific article published in 2024

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

scholarly article by Wenyan He et al published 18 December 2018 in Immunity

Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands

scientific article

Core 2 ß1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1.

scientific article

Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity.

scientific article published on 14 June 2017

Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

scientific article published on 09 March 2009

Cutaneous white spots in a child with polycystic kidneys: a clue to TSC2/PKD1 gene mutation

article

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

scientific article published on 24 January 2020

Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication

scientific article

Delayed but functional neutrophil extracellular trap formation in neonates

scientific article published on 01 November 2009

Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny

scientific article published on 17 May 2015

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

scientific article published on 06 September 2018

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

scientific article published on 15 November 2018

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

scientific article published on 29 August 2016

Editorial to the SI Leukocyte Adhesion and Migration

scientific article published on 11 January 2013

Effectiveness and Side Effects of an Escalating, Stepwise Approach to Indomethacin Treatment for Symptomatic Patent Ductus Arteriosus in Premature Infants Below 33 Weeks of Gestation

scientific article published on 01 December 2005

Endothelial RAGE exacerbates acute postischaemic cardiac inflammation

scientific article published on 2 June 2016

Endothelial cell-derived chemerin promotes dendritic cell transmigration

scientific article published on 27 January 2014

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

scientific article

Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines

scientific article published on 26 July 2012

Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice

scientific article published on 01 October 2019

Glycosylation in immune cell trafficking

scientific article published on July 2009

Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II.

scientific article published on 2 February 2007

Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response

scientific article

High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis

scientific article published on 21 March 2013

High-Dose Indomethacin for Patent Ductus Arteriosus Closure: How Strong Is the Evidence?: In Reply

article

How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell-cell interactions

scientific article

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation

scientific article published on 03 May 2022

Innate immune cell recruitment in the fetus and neonate

scientific article published on 08 June 2011

Interleukin-1R8: balancing inflammation and hemostasis in platelets

scientific article published on 12 August 2016

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice

scientific article

Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

scientific journal article

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

scientific article

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

scientific article published on 21 November 2018

Leukocyte Adhesion Deficiency-III: When Leukocytes Cannot Stop

scientific article published on 01 April 2010

Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc.

scientific article

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

scientific article

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane

scientific article

Maturation of Platelet Function During Murine Fetal Development In Vivo.

scientific article

Microvascular blood flow resistance: role of endothelial surface layer

scientific article

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

scientific article published on 5 October 2015

Myeloid-related protein 14 promotes inflammation and injury in meningitis

scientific article published on 20 January 2015

Myeloperoxidase attracts neutrophils by physical forces

scientific article published on 27 October 2010

Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease

scientific article published on 03 October 2012

Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation

scientific article published on 27 February 2018

NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.

scientific article

Neutrophil and endothelial adhesive function during human fetal ontogeny

scientific article

Neutrophil recruitment and intracellular vesicle transport: a short overview

scientific article published on 14 April 2020

Neutrophils as emerging therapeutic targets

scientific article published on 22 January 2020

Noncanonical Hippo Signalling in the Regulation of Leukocyte Function

scientific article published on 26 June 2018

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels

scientific article published on 22 March 2013

Ontogeny of platelet function

scientific article published on 01 February 2019

P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules

scientific article

P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow

scientific article

Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib

scientific article

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

scientific article published on 23 July 2015

Posttranslational sialylation and its impact on leukocyte recruitment during inflammation

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells

scientific article published on 02 November 2018

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90

scientific article published on 27 August 2020

Progesterone and cyclic adenosine monophosphate down-regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings

scientific article published on 26 August 2018

Prostaglandin E2 receptor 3 (EP3) signaling is induced in placentas with unexplained recurrent pregnancy losses (uRPL).

scientific article published on 26 April 2018

Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis

scientific article published on 8 November 2007

Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation

scientific article published on 9 September 2011

RAGE Signaling in Cell Adhesion and Inflammation

RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo

scientific article published on 20 April 2010

RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner

scientific article

Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.

scientific article published on 26 August 2016

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

scientific article

Recurrent infection progressively disables host protection against intestinal inflammation.

scientific article published in December 2017

Resistance to blood flow in microvessels in vivo

scientific article published in November 1994

S100A8/A9: From basic science to clinical application

scientific article

SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization

scientific article published in September 2013

Selectins and glycosyltransferases in leukocyte rolling in vivo

scientific article published on 5 September 2006

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice

scientific article

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation

scientific article

Sialyltransferase specificity in selectin ligand formation

scientific article published on 25 July 2002

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

scientific article published on 2 April 2015

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

scientific article

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration

scientific article published on 07 November 2019

The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood-Tissue Border

scientific article

The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils

scientific article published on 13 April 2011

The Mammalian Actin-Binding Protein 1 Is Critical for Spreading and Intraluminal Crawling of Neutrophils under Flow Conditions

scientific article published on 26 March 2012

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration

The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis.

scientific article

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

scientific article

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via 2 integrins (CD11/CD18)

scientific article published on 23 January 2014

The expanding role of α2‐3 sialylation for leukocyte trafficking in vivo ⬇️

scientific article published on January 18, 2012

The mammalian actin-binding protein 1 (mAbp1): a novel molecular player in leukocyte biology

scientific article published on 12 January 2011

The molecular basis of leukocyte recruitment and its deficiencies

scientific article published on 17 December 2012

Trophoblast Cell Lines JAR and JEG-3 Modulate CD90 (Thy‑1) Expression on Decidual Stromal Cells

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating beta2 integrin clustering

scientific article published on 23 July 2020

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.

scientific article

α2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammation

scholarly article by Markus Sperandio et al published December 2006 in European Journal of Immunology

List of works by Markus Sperandio

A Novel ex vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks

A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase

Analysis of leukocyte rolling in vivo and in vitro

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin

Blood flow resistance during hemodilution: effect of plasma composition

CEP: a new β2integrin ligand in inflamed tissue

Calcium signalling and related ion channels in neutrophil recruitment and function

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis

Circadian Clock and Hypoxia

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands

Core 2 ß1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1.

Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity.

Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

Cutaneous white spots in a child with polycystic kidneys: a clue to TSC2/PKD1 gene mutation

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication

Delayed but functional neutrophil extracellular trap formation in neonates

Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

Editorial to the SI Leukocyte Adhesion and Migration

Effectiveness and Side Effects of an Escalating, Stepwise Approach to Indomethacin Treatment for Symptomatic Patent Ductus Arteriosus in Premature Infants Below 33 Weeks of Gestation

Endothelial RAGE exacerbates acute postischaemic cardiac inflammation

Endothelial cell-derived chemerin promotes dendritic cell transmigration

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines

Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice

Glycosylation in immune cell trafficking

Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II.

Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response

High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis

High-Dose Indomethacin for Patent Ductus Arteriosus Closure: How Strong Is the Evidence?: In Reply

How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell-cell interactions

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation

Innate immune cell recruitment in the fetus and neonate

Interleukin-1R8: balancing inflammation and hemostasis in platelets

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice

Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Leukocyte Adhesion Deficiency-III: When Leukocytes Cannot Stop

Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc.

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane

Maturation of Platelet Function During Murine Fetal Development In Vivo.

Microvascular blood flow resistance: role of endothelial surface layer

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

Myeloid-related protein 14 promotes inflammation and injury in meningitis

Myeloperoxidase attracts neutrophils by physical forces

Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease

Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation

NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.

Neutrophil and endothelial adhesive function during human fetal ontogeny

Neutrophil recruitment and intracellular vesicle transport: a short overview

Neutrophils as emerging therapeutic targets

Noncanonical Hippo Signalling in the Regulation of Leukocyte Function

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels

Ontogeny of platelet function

P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules

P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow

Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Posttranslational sialylation and its impact on leukocyte recruitment during inflammation

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90

Progesterone and cyclic adenosine monophosphate down-regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings

Prostaglandin E2 receptor 3 (EP3) signaling is induced in placentas with unexplained recurrent pregnancy losses (uRPL).

Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis

Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation

RAGE Signaling in Cell Adhesion and Inflammation

RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo

RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner

Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.

Rac signal adaptation controls neutrophil mobilization from the bone marrow.