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List of works by Lu Lu

3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry

article

A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor

scientific article published on 18 September 2019

A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue

scientific article published on 27 September 2019

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin.

scientific article published on 27 September 2017

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

scientific article

A nanoparticle-encapsulated non-nucleoside reverse-transcriptase inhibitor with enhanced anti-HIV-1 activity and prolonged circulation time in plasma

scientific article published on January 2015

A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity

scientific article published on 24 January 2017

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

scientific article published on 19 January 2022

A novel bispecific peptide HIV-1 fusion inhibitor targeting the N-terminal heptad repeat and fusion peptide domains in gp41.

scientific article published on 8 September 2016

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

scientific article published on 05 February 2020

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

scientific article published on 10 April 2019

A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC.

scientific article

A randomized open-label clinical trial of an anti-HPV biological dressing (JB01-BD) administered intravaginally to treat high-risk HPV infection

scientific article published on 23 October 2015

ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer

scientific article published on 3 January 2014

ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection.

scientific article

Adding an Artificial Tail-Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile.

scientific article published on 20 November 2017

Adenovirus-based vaccines against avian-origin H5N1 influenza viruses.

scientific article

Advancements in Developing Strategies for Sterilizing and Functional HIV Cures.

scientific article

Advancements in the development of subunit influenza vaccines

scientific article

An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells

scientific article published on 01 June 2020

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides

scientific article published on 21 June 2013

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

scientific article published on 22 June 2016

Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains

scientific article

Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket

scientific article published on 11 January 2013

Biosecurity and biosafety in research on emerging pathogens

scientific article published on 21 November 2012

Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases

scientific article published on 28 May 2020

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

scientific article

Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity

scientific article published on 11 December 2018

Chemically Modified Human Serum Albumin Potently Blocks Entry of Ebola Pseudoviruses and Viruslike Particles

scientific article published on 6 February 2017

Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection

scientific article published on 19 March 2013

Chidamide, a histone deacetylase inhibitor-based anticancer drug, effectively reactivates latent HIV-1 provirus.

scientific article published on 7 November 2017

Co-delivery of HIV-1 entry inhibitor and nonnucleoside reverse transcriptase inhibitor shuttled by nanoparticles: cocktail therapeutic strategy for antiviral therapy.

scientific article published on 20 November 2015

Controlling HIV sexual transmission: a major challenge for China's new leadership

scientific article published on 19 March 2013

Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.

scientific article published on 19 October 2016

Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

scientific article published on 06 October 2020

Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex

scientific article published on 25 September 2019

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

scientific article

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

scientific article

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

scientific article published on 01 August 2019

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

scientific article published on September 2015

Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

scientific article

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses

scientific article published on 23 November 2017

Development of therapeutics for treatment of Ebola virus infection.

scientific article

Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

scientific article published in 2022

Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection

scientific article published on 11 November 2020

Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1

scientific article

Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator

scientific article published on 15 November 2019

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

scientific article

F(ab')2 fragment of a gp41 NHR-trimer-induced IgM monoclonal antibody neutralizes HIV-1 infection and blocks viral fusion by targeting the conserved gp41 pocket

scientific article published on 17 October 2013

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

scientific article published on 11 February 2020

Genomic signature analysis of the recently emerged highly pathogenic A(H5N8) avian influenza virus: implying an evolutionary trend for bird-to-human transmission

scientific article published on 7 September 2017

Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China

scientific article

HIV-1 Env DNA prime plus gp120 and gp70-V1V2 boosts induce high level of V1V2-specific IgG and ADCC responses and low level of Env-specific IgA response: implication for improving RV144 vaccine regimen.

scientific article published on 29 November 2017

HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.

scientific article published on 19 May 2014

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain

scientific article

Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat-C-terminal heptad repeat interactions and C-peptides' anti-HIV activity

scientific article published on June 2014

Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development

article

Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure.

scientific article

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development

scientific article

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus.

scientific article

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies

scientific article published on 05 December 2019

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

scientific article

In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor ⬇️

scientific article published on November 23, 2010

Inefficiency of Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV Infection

scientific article published on 31 March 2020

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

scientific article published on 30 March 2020

Intranasal administration of maleic anhydride-modified human serum albumin for pre-exposure prophylaxis of respiratory syncytial virus infection

scientific article

Intranasal application of polyethyleneimine suppresses influenza virus infection in mice

scientific article published on 27 April 2016

MERS-CoV spike protein: a key target for antivirals

scientific article

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

scientific article

Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread

scientific article

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III.

scientific article published on 11 October 2017

Neutralization sensitivity of HIV-1 subtype B' clinical isolates from former plasma donors in China

scientific article

Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy.

scientific article published on 22 April 2015

Normal human sera contain heat-sensitive factor(s) to enhance H7N9 influenza virus infection

scientific article

PA-356R is a unique signature of the avian influenza A (H7N9) viruses with bird-to-human transmissibility: potential implication for animal surveillances.

scientific article published on 9 August 2013

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains.

scientific article published on 6 February 2018

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

scientific article

Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection

scientific article

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

scientific article published on 14 January 2019

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

scientific article published on 17 February 2020

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

scientific article

Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity

scientific article published on 01 February 2020

Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4.

scientific article

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

scientific article published on 27 November 2020

Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations.

scientific article

Receptor binding domain based HIV vaccines.

scientific article

Receptor-binding domain as a target for developing SARS vaccines.

scientific article

Receptor-binding domain-based subunit vaccines against MERS-CoV

scientific article

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines.

scientific article published on 8 August 2012

Respiratory syncytial virus entry inhibitors targeting the F protein

scientific article published on 16 January 2013

Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

scientific article published on 10 July 2020

Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41

scientific article published on 01 August 2019

SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

scientific article published on 07 April 2020

Safety evaluation of chemically modified beta-lactoglobulin administered intravaginally

scientific article

Serological investigation of subclinical influenza A(H7H9) infection among healthcare and non-healthcare workers in Zhejiang Province, China

scientific article published on 11 June 2013

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.

scientific article published on 26 August 2016

Small molecule fusion inhibitors: design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41.

scientific article

Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015).

scientific article published on 11 January 2017

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

scientific article

Synergistic effect resulting from combinations of a bifunctional HIV-1 antagonist with antiretroviral drugs.

scientific article

Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry

scientific article published on 20 October 2014

The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

scientific article published on 06 November 2018

The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates

scientific article (publication date: 2012)

The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry

scientific article

The outbreak of avian influenza A (H7N9) in China: current status and future prospects

scientific article published in May 2013

The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

scientific article published on 12 June 2020

Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination

scientific article published on 30 October 2018

Urgent development of effective therapeutic and prophylactic agents to control the emerging threat of Middle East respiratory syndrome (MERS).

scientific article published on 17 June 2015

Virtual screening of small molecular HIV-1 entry inhibitor NC-2 targeting gp120 and its action mechanism

scientific article

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