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List of works by Frederik Steyn

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

scientific article

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

scientific article published on 23 November 2017

Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state.

scientific article published on December 2014

Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca(2+) signalling in rat somatotrophs in vitro

scientific article

Altered Metabolic Homeostasis in Amyotrophic Lateral Sclerosis: Mechanisms of Energy Imbalance and Contribution to Disease Progression.

scientific article

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

scientific article published on 06 July 2015

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis

scientific article published on 24 September 2020

An Early Reduction in GH Peak Amplitude in Preproghrelin-Deficient Male Mice Has a Minor Impact on Linear Growth

scientific article published on 20 June 2014

Anthropometric measures are not accurate predictors of fat mass in ALS.

scientific article published on 27 April 2017

Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA.

scientific article published on 2 February 2015

Biomarkers of Metabolism in Amyotrophic Lateral Sclerosis

scientific article published on 18 March 2019

Body mass index and dietary intervention: implications for prognosis of amyotrophic lateral sclerosis.

scientific article published on 03 March 2014

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

scientific article published on 12 July 2019

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article

Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activity.

scientific article published on 28 September 2017

Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles.

scientific article published on 13 September 2016

Development of a method for the determination of pulsatile growth hormone secretion in mice

scientific article published on 17 May 2011

Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice

scientific article

Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus

scientific article published in January 2007

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice

scientific article published on 7 October 2015

Endocrine rhythms of growth hormone release: Insights from animal studies.

scientific article published on 8 November 2017

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions

scientific article published on 25 July 2017

Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation

scientific article published on 01 October 2007

GH does not modulate the early fasting-induced release of free fatty acids in mice.

scientific article published on 22 November 2011

Gender differences in autoimmune disease

scientific article

Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line.

scientific article published on 7 September 2012

Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice

scientific article published on 9 October 2013

Gut microbiota in ALS: possible role in pathogenesis?

scientific article published on 29 May 2019

Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy

scientific journal article

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

scientific article published on 29 April 2018

Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

scientific article published on 25 August 2016

Hypothalamic distribution of somatostatin mRNA expressing neurones relative to pubertal and adult changes in pulsatile growth hormone secretion in mice

scientific article

Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol

scientific article published on 27 December 2007

IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction

scientific article published on 01 March 2020

Impairments to the GH-IGF-I axis in hSOD1G93A mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis.

scientific article published on 23 May 2012

In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue

scientific article published on 29 August 2015

Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain.

scientific article published on 13 July 2013

Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators

scientific article published on 13 January 2012

Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery

scientific article

Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults

scientific article published on 12 April 2014

Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis

scientific article published on 30 May 2019

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

scientific article published on 26 March 2021

Neuroendocrine Regulation of Growth Hormone Secretion.

scientific article

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.

scientific article published on 23 January 2018

New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency.

scientific article published on 21 February 2017

Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

scientific article published on 27 December 2016

Nutrient Sensing Overrides Somatostatin and Growth Hormone-Releasing Hormone to Control Pulsatile Growth Hormone Release

scientific article published on July 2015

Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management

scientific article published on 16 October 2013

Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction

scientific article published on 08 September 2018

Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion

scientific article published on 08 February 2008

Prognostic value of weight loss in patients with amyotrophic lateral sclerosis

scientific article published on 23 June 2020

Progression and survival of patients with motor neuron disease relative to their fecal microbiota

scientific article published on 09 July 2020

Pulse and Surge Profiles of Luteinizing Hormone Secretion in the Mouse.

scientific article

Response to Letter to the Editor: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction

scientific article published on 24 March 2020

Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse.

scientific article published on 20 April 2017

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

scientific article published on 27 February 2020

The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses

scientific article published on 20 April 2016

The decline in pulsatile GH secretion throughout early adulthood in mice is exacerbated by dietary-induced weight gain.

scientific article published on 16 July 2012

The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis.

scientific article published on 27 August 2015

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

scientific article published on 20 August 2016

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