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List of works by James Dooley

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

scientific article published on 06 December 2012

Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation

scientific article published in March 2007

Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation

scientific article published on October 2008

An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice

scientific article published in October 2005

An orthologous non-MHC locus in rats and mice is linked to CD4(+) and CD8(+) T-cell proportion

scientific article published on 25 May 2017

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

scientific article published on 26 May 2022

C-kit is important for SOD1(G93A) mouse survival independent of mast cells.

scientific article

Cervical thymus in the mouse

scientific article published on 01 June 2006

Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice

scientific article published on 25 January 2017

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

scientific article published on 12 October 2014

Developmental regulation of Foxp3 expression during ontogeny.

scientific article

Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS.

scientific article published on 19 October 2017

FGFR2IIIb signaling regulates thymic epithelial differentiation

scientific article

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. ⬇️

scientific article

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

scientific article

Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding.

scientific article published on 18 July 2014

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency.

scientific article published on 25 November 2014

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

scientific article published on 2 January 2016

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis

scientific article

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways

scientific article published on 26 March 2014

Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis

scientific article published on 20 January 2017

Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium

scientific article published on 28 September 2009

Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development

scientific article published on 01 April 2007

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.

scientific article published on 4 January 2012

MicroRNA regulation of T-cell development.

scientific article published on May 2013

MicroRNA-29 in the adaptive immune system: setting the threshold.

scientific article published on 13 September 2012

MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection ⬇️

scientific article published on September 12, 2012

Models of aire-dependent gene regulation for thymic negative selection.

scientific article published on 09 May 2011

Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue

scientific article

Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation

scientific article

NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer

scientific article published on 24 September 2017

No Effect of Dietary Aspartame or Stevia on Pancreatic Acinar Carcinoma Development, Growth, or Induced Mortality in a Murine Model

scientific article published on 09 February 2017

No Functional Role for microRNA-342 in a Mouse Model of Pancreatic Acinar Carcinoma.

scientific article

No evidence for a role of rareCYP27B1functional variations in multiple sclerosis

scientific article published on 11 March 2013

Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium.

scientific article

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation.

scientific article

Premature thymic involution is independent of structural plasticity of the thymic stroma.

scientific article

Programmed cell death-1 expression correlates with disease severity and IL-5 in chronic rhinosinusitis with nasal polyps

scientific article published on 25 January 2017

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells

scientific article published on 23 December 2014

Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis

scientific article

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

scientific article published on 11 September 2013

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

The cellular composition of the human immune system is shaped by age and cohabitation.

scientific article published on 15 February 2016

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity

scientific article published on January 2016

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

scientific article published on 18 December 2011

The thymic niche does not limit development of the naturally diverse population of mouse regulatory T lymphocytes

scientific article published on 17 September 2012

The thymoprotective function of leptin is indirectly mediated via suppression of obesity.

scientific article published on 14 July 2015

Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice.

scientific article published on 20 February 2015

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a

scientific article

miR-29a-deficiency does not modify the course of murine pancreatic acinar carcinoma.

scientific article

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