List of works - Lorenzo Stella

7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs

scientific article

A combined spectroscopic and theoretical study of a series of conformationally restricted hexapeptides carrying a rigid binaphthyl-nitroxide donor-acceptor pair.

scientific article published in September 2003

A reassessment of the association between azulene and [60]fullerene. Possible pitfalls in the determination of binding constants through fluorescence spectroscopy.

scientific article published in September 2008

A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome

scientific article published on January 2012

A spectroscopic and molecular mechanics investigation on a series of AIB-based linear peptides and a peptide template, both containing tryptophan and a nitroxide derivative as probes

scientific article published on 01 February 2000

A spectroscopic and molecular modeling study on novel pseudopeptides exhibiting biological activity

scientific article published on 01 October 1999

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

scientific article

Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues

scientific article published on 01 June 2007

Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions

scientific article published on 2 October 2007

Analysing protein energy data by a stochastic model for cooperative interactions: comparison and characterization of cooperativity.

scientific article

Cell-Density Dependence of Host-Defense Peptide Activity and Selectivity in the Presence of Host Cells

scientific article

Conformational effects on the electron-transfer efficiency in peptide foldamers based on alpha,alpha-disubstituted glycyl residues

scientific article published in July 2008

Conformational properties, membrane interaction, and antibacterial activity of the peptaibiotic chalciporin A: Multitechnique spectroscopic and biophysical investigations on the natural compound and labeled analogs.

scientific article published on 11 November 2017

Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.

scientific article published on 11 May 2005

Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome

scientific article published on 18 June 2012

Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide

scientific article published on 18 June 2019

Different mechanisms of action of antimicrobial peptides: insights from fluorescence spectroscopy experiments and molecular dynamics simulations.

scientific article

Discriminating between Different Heavy Metal Ions with Fullerene-Derived Nanoparticles.

scientific article

Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes

scientific article

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

scientific article

Dynamics of formation of a helix-turn-helix structure in a membrane-active peptide: a time-resolved spectroscopic study

scientific article published on 01 January 2006

Effect of Lys→Arg mutation on the thermal stability of Cu,Zn superoxide dismutase: influence on the monomer–dimer equilibrium

scientific article published on 01 April 1996

Effect of peptide lipidation on membrane perturbing activity: a comparative study on two trichogin analogues

scientific article published on 01 November 2006

Electroconductive and photocurrent generation properties of self-assembled monolayers formed by functionalized, conformationally-constrained peptides on gold electrodes

scientific article published in February 2008

Electrophysiology investigation of Trichogin GA IV activity in planar lipid membranes reveals ion channels of well-defined size

scientific article published in July 2014

Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope

scientific journal article

Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences

scientific article

Enhancing the Antimicrobial Activity of Alamethicin F50/5 by Incorporating N-terminal Hydrophobic Triazole Substituents.

scientific article published on 18 September 2017

Esculentin 1-21: a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria

scientific article

Esculentin-1b(1-18)--a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli

scientific article published on 02 September 2009

Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.

scientific article published on 3 November 2010

Fibrils or globules? Tuning the morphology of peptide aggregates from helical building blocks.

scientific article published on 26 April 2013

First Italy-Korea Symposium on antimicrobial peptides held at the Chosun University, Gwangju, Republic of Korea, on July 24-25, 2008.

scientific article published in September 2009

Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy

scientific article published on 01 September 1998

Fluctuations and the rate-limiting step of peptide-induced membrane leakage.

scientific article published on September 2010

Fluorescence spectroscopy and molecular dynamics simulations in studies on the mechanism of membrane destabilization by antimicrobial peptides.

scientific article published on 17 May 2011

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

scientific article

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

scientific article published on November 2003

How many antimicrobial peptide molecules kill a bacterium? The case of PMAP-23.

scientific article published on 30 July 2014

Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme

scientific article

Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors

journal article published in 2018

Mechanism of membrane activity of the antibiotic trichogin GA IV: a two-state transition controlled by peptide concentration.

scientific article published on 18 February 2005

Membrane perturbation by the antimicrobial peptide PMAP-23: a fluorescence and molecular dynamics study

scientific article

Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV

scientific article published on 05 December 2012

Metal binding properties of fluorescent analogues of trichogin GA IV: a conformational study by time-resolved spectroscopy and molecular mechanics investigations.

scientific article

Molecular dynamics methods to predict peptide locations in membranes: LAH4 as a stringent test case.

scientific article

Molecular dynamics simulations of human glutathione transferase P1-1: analysis of the induced-fit mechanism by GSH binding

scientific article published on 01 October 1999

Molecular dynamics simulations of human glutathione transferase P1-1: conformational fluctuations of the apo-structure

scientific article published on 01 October 1999

Monomer-dimer equilibrium in glutathione transferases: a critical re-examination.

scientific article published in November 2009

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

scientific article published on 27 April 2015

Mutations in PAX2 associate with adult-onset FSGS

scientific article

Mutations in ZBTB20 cause Primrose syndrome

scientific article

New insights into the mechanism of JNK1 inhibition by glutathione transferase P1-1.

scientific article published on 5 September 2012

Novel SMAD4 mutation causing Myhre syndrome

scientific article (publication date: July 2014)

Nuclear shield: a multi-enzyme task-force for nucleus protection

scientific article

Peptide folding dynamics: a time-resolved study from the nanosecond to the microsecond time regime

scientific article published on 01 November 2006

Peptide-sandwiched protoporphyrin compounds mimicking hemoprotein structures in solution

scientific article published on 01 August 2000

Peptides at work: from structure to applications

scientific article published on 01 May 2011

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

scientific article

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles.

scientific article published on 27 April 2018

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

scientific article

Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2

scientific article published on 01 March 2007

Structural features and conformational equilibria of 310-helical peptides in solution by spectroscopic and molecular mechanics studies

scientific article published on 01 January 2002

Structural features of linear (alphaMe)Val-based peptides in solution by photophysical and theoretical conformational studies

scientific article published on 01 January 2000

Structural features of linear, homo-Aib-based peptides in solution: a spectroscopic and molecular mechanics investigation

scientific article published on 01 November 2000

Structural features of model glycopeptides in solution and in membrane phase: a spectroscopic and molecular mechanics investigation.

scientific article

Structural properties and photophysical behavior of conformationally constrained hexapeptides functionalized with a new fluorescent analog of tryptophan and a nitroxide radical quencher

scientific article published in October 2004

Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.

scientific article published on 16 June 2009

The extended catalysis of glutathione transferase

scientific article published on 14 December 2010

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force

scientific article published on 03 July 2013

The importance of being kinked: role of Pro residues in the selectivity of the helical antimicrobial peptide P5.

scientific article

The lipid dependence of antimicrobial peptide activity is an unreliable experimental test for different pore models.

scientific article

The role of aromatic radical cations and benzylic cations in the 2,4,6-triphenylpyrylium tetrafluoroborate photosensitized oxidation of ring-methoxylated benzyl alcohols in CH2Cl2 solution.

scientific article

The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide

scientific article

The thin line between cell-penetrating and antimicrobial peptides: the case of Pep-1 and Pep-1-K.

scientific article

Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers

scientific article published on 17 July 2019

Trichogin GA IV: an antibacterial and protease-resistant peptide

scientific article published in September 2009

Zinc ion coordination as a modulating factor of the ZnuA histidine-rich loop flexibility: A molecular modeling and fluorescence spectroscopy study

scientific article published on 01 December 2012

List of works by Lorenzo Stella

7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs

A combined spectroscopic and theoretical study of a series of conformationally restricted hexapeptides carrying a rigid binaphthyl-nitroxide donor-acceptor pair.

A reassessment of the association between azulene and [60]fullerene. Possible pitfalls in the determination of binding constants through fluorescence spectroscopy.

A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome

A spectroscopic and molecular mechanics investigation on a series of AIB-based linear peptides and a peptide template, both containing tryptophan and a nitroxide derivative as probes

A spectroscopic and molecular modeling study on novel pseudopeptides exhibiting biological activity

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues

Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions

Analysing protein energy data by a stochastic model for cooperative interactions: comparison and characterization of cooperativity.

Cell-Density Dependence of Host-Defense Peptide Activity and Selectivity in the Presence of Host Cells

Conformational effects on the electron-transfer efficiency in peptide foldamers based on alpha,alpha-disubstituted glycyl residues

Conformational properties, membrane interaction, and antibacterial activity of the peptaibiotic chalciporin A: Multitechnique spectroscopic and biophysical investigations on the natural compound and labeled analogs.

Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.

Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome

Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide

Different mechanisms of action of antimicrobial peptides: insights from fluorescence spectroscopy experiments and molecular dynamics simulations.

Discriminating between Different Heavy Metal Ions with Fullerene-Derived Nanoparticles.

Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

Dynamics of formation of a helix-turn-helix structure in a membrane-active peptide: a time-resolved spectroscopic study

Effect of Lys→Arg mutation on the thermal stability of Cu,Zn superoxide dismutase: influence on the monomer–dimer equilibrium

Effect of peptide lipidation on membrane perturbing activity: a comparative study on two trichogin analogues

Electroconductive and photocurrent generation properties of self-assembled monolayers formed by functionalized, conformationally-constrained peptides on gold electrodes

Electrophysiology investigation of Trichogin GA IV activity in planar lipid membranes reveals ion channels of well-defined size

Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope

Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences

Enhancing the Antimicrobial Activity of Alamethicin F50/5 by Incorporating N-terminal Hydrophobic Triazole Substituents.

Esculentin 1-21: a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria

Esculentin-1b(1-18)--a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli

Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.

Fibrils or globules? Tuning the morphology of peptide aggregates from helical building blocks.

First Italy-Korea Symposium on antimicrobial peptides held at the Chosun University, Gwangju, Republic of Korea, on July 24-25, 2008.

Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy

Fluctuations and the rate-limiting step of peptide-induced membrane leakage.

Fluorescence spectroscopy and molecular dynamics simulations in studies on the mechanism of membrane destabilization by antimicrobial peptides.

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

How many antimicrobial peptide molecules kill a bacterium? The case of PMAP-23.

Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme

Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors

Mechanism of membrane activity of the antibiotic trichogin GA IV: a two-state transition controlled by peptide concentration.

Membrane perturbation by the antimicrobial peptide PMAP-23: a fluorescence and molecular dynamics study

Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV

Metal binding properties of fluorescent analogues of trichogin GA IV: a conformational study by time-resolved spectroscopy and molecular mechanics investigations.

Molecular dynamics methods to predict peptide locations in membranes: LAH4 as a stringent test case.

Molecular dynamics simulations of human glutathione transferase P1-1: analysis of the induced-fit mechanism by GSH binding

Molecular dynamics simulations of human glutathione transferase P1-1: conformational fluctuations of the apo-structure

Monomer-dimer equilibrium in glutathione transferases: a critical re-examination.

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

Mutations in PAX2 associate with adult-onset FSGS

Mutations in ZBTB20 cause Primrose syndrome

New insights into the mechanism of JNK1 inhibition by glutathione transferase P1-1.

Novel SMAD4 mutation causing Myhre syndrome

Nuclear shield: a multi-enzyme task-force for nucleus protection

Peptide folding dynamics: a time-resolved study from the nanosecond to the microsecond time regime

Peptide-sandwiched protoporphyrin compounds mimicking hemoprotein structures in solution

Peptides at work: from structure to applications

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles.

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2

Structural features and conformational equilibria of 310-helical peptides in solution by spectroscopic and molecular mechanics studies

Structural features of linear (alphaMe)Val-based peptides in solution by photophysical and theoretical conformational studies

Structural features of linear, homo-Aib-based peptides in solution: a spectroscopic and molecular mechanics investigation

Structural features of model glycopeptides in solution and in membrane phase: a spectroscopic and molecular mechanics investigation.

Structural properties and photophysical behavior of conformationally constrained hexapeptides functionalized with a new fluorescent analog of tryptophan and a nitroxide radical quencher

Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119.

The extended catalysis of glutathione transferase

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force

The importance of being kinked: role of Pro residues in the selectivity of the helical antimicrobial peptide P5.

The lipid dependence of antimicrobial peptide activity is an unreliable experimental test for different pore models.

The role of aromatic radical cations and benzylic cations in the 2,4,6-triphenylpyrylium tetrafluoroborate photosensitized oxidation of ring-methoxylated benzyl alcohols in CH2Cl2 solution.

The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide

The thin line between cell-penetrating and antimicrobial peptides: the case of Pep-1 and Pep-1-K.

Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers

Trichogin GA IV: an antibacterial and protease-resistant peptide

Zinc ion coordination as a modulating factor of the ZnuA histidine-rich loop flexibility: A molecular modeling and fluorescence spectroscopy study