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List of works by Philippe Bouillet

A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid

article

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

A tumor suppressor function for caspase-2

scholarly article

AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis

article

AP-2.2: a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells

scientific article published in June 1996

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

scientific article published on June 2002

Adenosine A2Areceptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77

scientific article published on 01 June 2006

Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.

scientific article published on 13 January 2012

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

scientific article published on January 2012

Anti-apoptotic gene Bcl2 is required for stapes development and hearing

scientific article

Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts

scientific article published on 21 October 2009

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone

scientific article

Antigen Challenge Inhibits Thymic Emigration

scientific article published on 3 April 2006

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

scientific article published on February 2008

Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation

scientific article published on 27 October 2010

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

scientific article

BCL-2 is dispensable for thrombopoiesis and platelet survival

scientific article

BCL2-modifying factor promotes germ cell loss during murine oogenesis

scientific article

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

scientific article (publication date: 21 February 2002)

BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

scientific article

BH3-only proteins and their roles in programmed cell death

scientific article published on December 2008

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

scientific journal article

Bax and Bak: back-bone of T cell death

scientific article published on 01 October 2002

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

scientific article published on 01 March 2015

Bcl-2 family member Bcl-G is not a proapoptotic protein.

scientific article

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

scientific article

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

Bim expression indicates the pathway to retinal cell death in development and degeneration.

scientific article published in October 2007

Bim is a suppressor of Myc-induced mouse B cell leukemia

scholarly article

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

scientific article

Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

scientific article published on 7 November 2017

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

scientific article

CD95, BIM and T cell homeostasis

scientific article published on July 2009

CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis

scientific article published on 12 April 2013

Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

scientific article published on October 2011

Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene

scientific journal article

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

scientific journal article

Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22.

scientific article published on October 1995

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

scientific journal article

Consequences of the combined loss of BOK and BAK or BOK and BAX.

scientific article published on 06 June 2013

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

scientific article published on 08 September 2018

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins

scientific article

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.

scientific article published on 10 March 2016

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

scientific article

Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease.

scientific article published on 9 February 2012

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

scientific article

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

scientific journal article

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.

scientific article published on 14 March 2014

Deregulation of TNF expression can also cause heart valve disease

scientific article published on 25 August 2015

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.

scientific article

Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies.

scientific article published on 23 August 2012

Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein

scientific article published in May 1997

Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation

scientific article published in April 2000

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

scientific article

ER stress triggers apoptosis by activating BH3-only protein Bim

scientific article (publication date: 29 June 2007)

Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2).

scientific article

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

scientific article

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

scientific article published on 20 December 2013

Erratum: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

scholarly article published in Cell Death & Differentiation

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

scientific article published on 14 November 2002

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

scientific article published on 31 July 2014

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

scientific article

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

scientific article

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis

scientific article published on 26 May 2014

Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

scientific article (publication date: February 2001)

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

scientific article

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

scientific article published on November 2013

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

scientific article published on 19 July 2013

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

scientific article published on 29 May 2007

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

scientific article published on 24 June 2013

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

scientific article published on 9 October 2014

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

scientific article

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

scientific article (publication date: March 2001)

Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death

scientific article published on 9 July 2008

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

scientific article published on 25 January 2016

Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells.

scientific article published in September 1996

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

scientific article

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

scientific article published on 25 April 2018

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

scientific article published in Nature Communications

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

scientific article published on 18 November 2016

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

scientific article

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

scientific journal article

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration

scientific article published in December 2003

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

scientific article

Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

scientific article published on 10 April 2014

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

scientific article published on December 2016

Mcl-1 is essential for germinal center formation and B cell memory

scientific article

Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells

scientific article published on October 1997

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

scientific article published on October 2009

MicroRNAs and lymphocyte homeostasis: dangerous eggs in a single basket

scientific article published on 20 May 2008

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

scientific article published in September 2005

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

scientific article published on 26 April 2004

Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells.

scientific article

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

scientific article

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Polycystic kidney disease prevented by transgenic RNA interference

scientific journal article

Pre-irradiation chemotherapy for newly diagnosed high grade astrocytoma.

scientific article

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

scientific article

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

article

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

scientific article

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

scientific article

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

scientific article published on 22 March 2018

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

scientific article (publication date: 26 November 1999)

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types

scientific article

Regulation of memory B-cell survival by the BH3-only protein Puma

scientific article

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

scientific article published on December 2003

Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification

scientific article published in January 1996

Role of BH3-only protein Bim in autoimmune and degenerative diseases.

scientific article published on 12 September 2003

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

scientific article published on 29 November 2009

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

scientific article

Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia

scientific article published on 15 June 2006

Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells

scientific article published in December 1995

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim ⬇️

scientific article published on November 17, 2003

Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis

scientific article

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily

scientific article published on 01 January 1998

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

scientific article published in January 2005

TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss

scientific article published on 12 January 2017

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

scientific article

The Bcl-2 family in autoimmune and degenerative disorders

scientific article published on April 2009

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

scientific article

The control of apoptosis in lymphocyte selection

scientific article

The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos

scientific article

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

scientific article published on 03 August 2009

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

scholarly article

Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo

scientific article

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

scientific article

XIAP discriminates between type I and type II FAS-induced apoptosis

scientific article

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