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List of works by Hubert Serve

A high BMI is a risk factor in younger patients with de novo acute myelogenous leukemia

scientific article published on 16 August 2015

A novel hierarchical prognostic model of AML solely based on molecular mutations

scientific article published on 20 August 2012

A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy

scientific article published on 19 June 2020

A special query tool in the hospital information system to recognize patients and to increase patient numbers for clinical trials

scientific article published in January 2012

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

article

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

scientific article published on 18 January 2011

ATR inhibition rewires cellular signaling networks induced by replication stress

scientific article published on 17 November 2015

Activation mechanisms of STAT5 by oncogenic Flt3-ITD.

scientific article published on 13 March 2007

Activation of Wnt signaling in cKit-ITD mediated transformation and imatinib sensitivity in acute myeloid leukemia

scientific article

Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4.

scientific article

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

scientific article published on 24 November 2016

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape

scientific article

Adaptor protein Lnk associates with Tyr(568) in c-Kit

scientific article

Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling

scientific article

Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

scientific article

Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial

scientific article

Adjuvant therapy for resectable high-risk soft tissue sarcoma: feasibility and efficacy of a sandwich chemoradiotherapy strategy

scientific article published on 24 September 2011

Adjuvant therapy with small hairpin RNA interference prevents non-small cell lung cancer metastasis development in mice

scientific article

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

scientific article published on 22 March 2012

Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia

scientific article published on 11 March 2016

Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD.

scientific article published on 6 November 2015

Allogeneic stem-cell transplantation in patients with NPM1-mutated acute myeloid leukemia: results from a prospective donor versus no-donor analysis of patients after upfront HLA typing within the SAL-AML 2003 trial

scientific article

Amsacrine containing induction therapy in elderly AML patients: comparison to standard induction regimens in a matched-pair analysis

scientific article published on 01 August 2007

An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia

scientific article published on 11 August 2009

Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis

scientific article published on 01 November 2007

Antifungal management and resource use in patients with acute myeloid leukaemia after chemotherapy--retrospective analysis of changes over 3 yr in a German hospital

scientific article published on 13 October 2011

Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the Study Alliance Leukemia.

scientific article published on 2 November 2015

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

scientific article

Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry.

scientific article published on 5 March 2016

CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells

scientific article

Chemomodulation of sequential high-dose cytarabine by fludarabine in relapsed or refractory acute myeloid leukemia: a randomized trial of the AMLCG.

scientific article published on 22 October 2013

Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip

scientific article published on 16 November 2007

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

scientific article published on 20 August 2019

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

scientific article published on 3 December 2010

Construction and application of an inducible system for homogenous expression levels in bulk cell lines

scientific article

Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.

scientific article published on 28 October 2013

DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells

scientific article published on August 2007

DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

scientific article published in February 2007

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

scientific article

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation

scientific article published on 01 February 2007

Decitabine treatment in 311 patients with acute myeloid leukemia: outcome and impact of <i>TP53</i> mutations - a registry based analysis

scientific article published on 05 January 2021

Deep sequencing in CD34+ cells from peripheral blood enables sensitive detection of measurable residual disease in AML

scientific article published on 01 June 2022

Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia?

scientific article published on 04 June 2020

Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient

scientific article published on 28 March 2017

Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG.

scientific article published on 8 January 2009

Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia

scientific article published on 01 June 2006

EZH2 mutations and impact on clinical outcome - an analysis in 1604 patients with newly diagnosed acute myeloid leukemia

scientific article published on 14 August 2019

Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival

scientific article published on 06 May 2016

Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation.

scientific article

Entospletinib in Combination With Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 expression

scientific article published on 20 August 2020

Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia

scientific article published in 2024

Evaluation of the proposed reporting system of the European LeukemiaNet and recommendations for prognosis of acute myeloid leukemia

scientific article published on 10 December 2012

FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.

scientific article

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study

scientific article

Flt3-dependent transformation by inactivating c-Cbl mutations in AML

scientific article published on 19 April 2007

Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms

scientific article published on 22 April 2009

Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy

scientific article published in 2021

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

scientific article published on 29 December 2011

Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib

scientific article published on 19 November 2013

Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors

scientific article published on December 2006

HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling

scientific article published on 15 November 2016

Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university hospitals, community hospitals, and office-based physicians.

scientific article published on 22 June 2016

Hematopoietic cell transplantation in patients with intermediate and high-risk AML: results from the randomized Study Alliance Leukemia (SAL) AML 2003 trial

scientific article published in December 2014

High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation

scientific article published on 28 June 2011

High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial

scientific article published on 29 April 2013

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia

scientific article

IT behind a platform for Translational Cancer Research - concept and objectives.

scientific article published in January 2012

Identification of acute myeloid leukaemia associated microRNA expression patterns

scientific article published on 01 January 2008

Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

scientific article published on 01 January 2020

Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia

scientific article published on 01 September 2021

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

scientific article

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

scientific article published on 22 December 2010

Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer.

scientific article published in April 2009

Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations

scientific article published on November 2010

Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia

scientific article published on 9 February 2016

Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: a randomized phase II trial in elderly patients

scientific article published on 02 August 2011

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

scientific article published on 12 March 2019

Karyotype complexity and prognosis in acute myeloid leukemia

scientific article published on 15 January 2016

Klinische Forschung im „European LeukemiaNet”

Leucodepletion for hyperleucocytosis--first report on a novel technology featuring electronic interphase management

scientific article published on 6 February 2013

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

scientific article published on 12 December 2016

Low SMC1A protein expression predicts poor survival in acute myeloid leukemia.

scientific article published in July 2010

Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial

scientific article published on 12 November 2018

Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia

scientific article published on 19 November 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

scientific article published on 23 June 2017

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

scientific article published in October 2009

Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia.

scientific article

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

scientific article published on 26 August 2015

New influenza A/H1N1 ("swine flu"): information needs of airport passengers and staff.

scientific article published on 24 August 2010

Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease

scientific article published on 11 January 2011

Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation

scientific article published on 08 November 2019

Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.

scientific article

Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.

scientific article published on 18 October 2007

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model

scientific article published on 9 March 2010

Plastic CD34 and CD38 expression in adult B-cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations.

scientific article

Potential interactions of complementary and alternative medicine with cancer therapy in outpatients with gynecological cancer in a comprehensive cancer center.

scientific article

Prevalence and dynamics of bcr-abl kinase domain mutations during imatinib treatment differ in patients with newly diagnosed and recurrent bcr-abl positive acute lymphoblastic leukemia.

scientific article published on 9 January 2012

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

scientific article

Quantitative mass spectrometric profiling of cancer-cell proteomes derived from liquid and solid tumors

scientific article published on 27 February 2015

RUNX1 cooperates with FLT3-ITD to induce leukemia.

scientific article published on 17 February 2017

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation

scientific article published on 24 April 2015

Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR-ABL1-positive acute lymphoblastic leukemia

scientific article published on 5 December 2012

Real-Time NMR Spectroscopy for Studying Metabolism

scientific article published on 20 December 2019

S100A2 induces metastasis in non-small cell lung cancer

scientific article published in January 2009

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

scientific article

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

scientific article

Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells.

scientific article published on 8 April 2016

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

scientific article published on 02 August 2019

Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis

scientific article published on 30 October 2013

Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3-Internal Tandem Duplication Mutation (SORMAIN)

scientific article published on 16 July 2020

Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial

scientific article published on 29 July 2013

Successful systemic high-dose ribavirin treatment of respiratory syncytial virus-induced infections occurring pre-engraftment in allogeneic hematopoietic stem cell transplant recipients

scientific article published on 20 May 2013

Survey and analysis of the efficacy and prescription pattern of sorafenib in patients with acute myeloid leukemia

scientific article published on 07 December 2011

Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity

scientific article published on 22 March 2021

TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation

scientific article

The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer

scientific article published on 6 April 2010

The European LeukemiaNet: achievements and perspectives

scientific article

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

scientific article published on 9 September 2015

The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells

scientific article published on 31 July 2010

The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.

scientific article published on 7 June 2007

Ubiquitination and selective autophagy

scientific article

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

scientific article

Wnt signaling regulates transendothelial migration of monocytes

scientific article published on 24 March 2006

[Characterization and economic impact of medical patients presenting at the emergency department of an university hospital].

scientific article published on 25 June 2013

[Patient blood management--How does it work in practice?--the interdisciplinary cooperation]

scientific article published on 01 April 2014

β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis

scientific article published on 18 March 2013

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